Antepartum Diagnosis and Management of Lamin A/C Disease
Lamin A/C cardiac disease is a genetic cardiomyopathy and arrhythmia syndrome caused by alterations in the function of the nuclear lamin A and C proteins. It is inherited in an autosomal dominant manner and usually presents in mid- to late adulthood with atrioventricular conduction abnormalities, at...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
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| Series: | Case Reports in Cardiology |
| Online Access: | http://dx.doi.org/10.1155/2019/3512706 |
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| _version_ | 1832549867169251328 |
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| author | Nosheen Reza Jessica L. Chowns Amy Marzolf Jessica Kim Lisa D. Levine Gregory Supple Anjali Tiku Owens |
| author_facet | Nosheen Reza Jessica L. Chowns Amy Marzolf Jessica Kim Lisa D. Levine Gregory Supple Anjali Tiku Owens |
| author_sort | Nosheen Reza |
| collection | DOAJ |
| description | Lamin A/C cardiac disease is a genetic cardiomyopathy and arrhythmia syndrome caused by alterations in the function of the nuclear lamin A and C proteins. It is inherited in an autosomal dominant manner and usually presents in mid- to late adulthood with atrioventricular conduction abnormalities, atrial and ventricular arrhythmias, biventricular dysfunction, and advanced heart failure. While rare, women of childbearing age can exhibit an aggressive disease course, and appropriate risk stratification and management are critical. Here, we present a case of newly diagnosed lamin A/C cardiac disease in a pregnant woman. |
| format | Article |
| id | doaj-art-8dbdd10fb8604425bef37b4323af6f44 |
| institution | Kabale University |
| issn | 2090-6404 2090-6412 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Cardiology |
| spelling | doaj-art-8dbdd10fb8604425bef37b4323af6f442025-02-03T06:08:27ZengWileyCase Reports in Cardiology2090-64042090-64122019-01-01201910.1155/2019/35127063512706Antepartum Diagnosis and Management of Lamin A/C DiseaseNosheen Reza0Jessica L. Chowns1Amy Marzolf2Jessica Kim3Lisa D. Levine4Gregory Supple5Anjali Tiku Owens6Center for Inherited Cardiovascular Disease, Division of Cardiovascular Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USACenter for Inherited Cardiovascular Disease, Division of Cardiovascular Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USACenter for Inherited Cardiovascular Disease, Division of Cardiovascular Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USACenter for Inherited Cardiovascular Disease, Division of Cardiovascular Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USAMaternal and Child Health Research Center, Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USACardiac Electrophysiology Section, Division of Cardiovascular Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USACenter for Inherited Cardiovascular Disease, Division of Cardiovascular Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USALamin A/C cardiac disease is a genetic cardiomyopathy and arrhythmia syndrome caused by alterations in the function of the nuclear lamin A and C proteins. It is inherited in an autosomal dominant manner and usually presents in mid- to late adulthood with atrioventricular conduction abnormalities, atrial and ventricular arrhythmias, biventricular dysfunction, and advanced heart failure. While rare, women of childbearing age can exhibit an aggressive disease course, and appropriate risk stratification and management are critical. Here, we present a case of newly diagnosed lamin A/C cardiac disease in a pregnant woman.http://dx.doi.org/10.1155/2019/3512706 |
| spellingShingle | Nosheen Reza Jessica L. Chowns Amy Marzolf Jessica Kim Lisa D. Levine Gregory Supple Anjali Tiku Owens Antepartum Diagnosis and Management of Lamin A/C Disease Case Reports in Cardiology |
| title | Antepartum Diagnosis and Management of Lamin A/C Disease |
| title_full | Antepartum Diagnosis and Management of Lamin A/C Disease |
| title_fullStr | Antepartum Diagnosis and Management of Lamin A/C Disease |
| title_full_unstemmed | Antepartum Diagnosis and Management of Lamin A/C Disease |
| title_short | Antepartum Diagnosis and Management of Lamin A/C Disease |
| title_sort | antepartum diagnosis and management of lamin a c disease |
| url | http://dx.doi.org/10.1155/2019/3512706 |
| work_keys_str_mv | AT nosheenreza antepartumdiagnosisandmanagementoflaminacdisease AT jessicalchowns antepartumdiagnosisandmanagementoflaminacdisease AT amymarzolf antepartumdiagnosisandmanagementoflaminacdisease AT jessicakim antepartumdiagnosisandmanagementoflaminacdisease AT lisadlevine antepartumdiagnosisandmanagementoflaminacdisease AT gregorysupple antepartumdiagnosisandmanagementoflaminacdisease AT anjalitikuowens antepartumdiagnosisandmanagementoflaminacdisease |