Theaflavin-3,3'-digallate alleviates glucolipotoxicity-induced insulin secretion dysfunction in pancreatic β-TC-6 cells and zebrafish via anti-ferroptotic mechanisms by activating SERCA2

Theaflavin-3,3'-digallate alleviates glucolipotoxicity-induced insulin secretion dysfunction in pancreatic β-TC-6 cells and zebrafish via anti-ferroptotic mechanisms by activating SERCA2

Theaflavins from black tea effectively improve insulin secretion in obesity and diabetes, but the molecular mechanisms are unclear. Here, the palmitic acid (PA)-induced pancreatic β-TC-6 cells and high fat-/high glucose-induced zebrafish were used. The effects of theaflavin-3,3’-digallate (TF3) on g...

Full description

Saved in:
Bibliographic Details
Main Authors: Kaixi Wang, Huanqing Zhu, Jiaxin Kang, Shuna Chen, Puming He, Youying Tu, Bo Li
Format: Article
Language:English
Published: Tsinghua University Press 2025-04-01
Series:Food Science and Human Wellness
Subjects:
theaflavin-3,3’-digallate
pancreatic β-cells
ferroptosis
endoplasmic reticulum stress
sarcoplasmic/endoplasmic reticulum calcium atpase 2
Online Access:https://www.sciopen.com/article/10.26599/FSHW.2024.9250096
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items