Monocytes as Regulators of Inflammation and HIV-Related Comorbidities during cART
Combined antiretroviral therapy (cART) extends the lifespan and the quality of life for HIV-infected persons but does not completely eliminate chronic immune activation and inflammation. The low level of chronic immune activation persisting during cART-treated HIV infection is associated with the de...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2014/569819 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832548066593341440 |
|---|---|
| author | Joshua J. Anzinger Tiffany R. Butterfield Thomas A. Angelovich Suzanne M. Crowe Clovis S. Palmer |
| author_facet | Joshua J. Anzinger Tiffany R. Butterfield Thomas A. Angelovich Suzanne M. Crowe Clovis S. Palmer |
| author_sort | Joshua J. Anzinger |
| collection | DOAJ |
| description | Combined antiretroviral therapy (cART) extends the lifespan and the quality of life for HIV-infected persons but does not completely eliminate chronic immune activation and inflammation. The low level of chronic immune activation persisting during cART-treated HIV infection is associated with the development of diseases which usually occur in the elderly. Although T-cell activation has been extensively examined in the context of cART-treated HIV infection, monocyte activation is only beginning to be recognized as an important source of inflammation in this context. Here we examine markers and sources of monocyte activation during cART-treated HIV infection and discuss the role of monocytes during cardiovascular disease, HIV-associated neurocognitive disorder, and innate immune aging. |
| format | Article |
| id | doaj-art-8d98fc8bc6324dd69881637b40cad904 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-8d98fc8bc6324dd69881637b40cad9042025-02-03T06:42:24ZengWileyJournal of Immunology Research2314-88612314-71562014-01-01201410.1155/2014/569819569819Monocytes as Regulators of Inflammation and HIV-Related Comorbidities during cARTJoshua J. Anzinger0Tiffany R. Butterfield1Thomas A. Angelovich2Suzanne M. Crowe3Clovis S. Palmer4Department of Microbiology, The University of the West Indies, Kingston, JamaicaDepartment of Microbiology, The University of the West Indies, Kingston, JamaicaCentre for Biomedical Research, Macfarlane Burnet Institute for Medical Research and Public Health, GPO Box 2284, Melbourne, VIC 3001, AustraliaCentre for Biomedical Research, Macfarlane Burnet Institute for Medical Research and Public Health, GPO Box 2284, Melbourne, VIC 3001, AustraliaCentre for Biomedical Research, Macfarlane Burnet Institute for Medical Research and Public Health, GPO Box 2284, Melbourne, VIC 3001, AustraliaCombined antiretroviral therapy (cART) extends the lifespan and the quality of life for HIV-infected persons but does not completely eliminate chronic immune activation and inflammation. The low level of chronic immune activation persisting during cART-treated HIV infection is associated with the development of diseases which usually occur in the elderly. Although T-cell activation has been extensively examined in the context of cART-treated HIV infection, monocyte activation is only beginning to be recognized as an important source of inflammation in this context. Here we examine markers and sources of monocyte activation during cART-treated HIV infection and discuss the role of monocytes during cardiovascular disease, HIV-associated neurocognitive disorder, and innate immune aging.http://dx.doi.org/10.1155/2014/569819 |
| spellingShingle | Joshua J. Anzinger Tiffany R. Butterfield Thomas A. Angelovich Suzanne M. Crowe Clovis S. Palmer Monocytes as Regulators of Inflammation and HIV-Related Comorbidities during cART Journal of Immunology Research |
| title | Monocytes as Regulators of Inflammation and HIV-Related Comorbidities during cART |
| title_full | Monocytes as Regulators of Inflammation and HIV-Related Comorbidities during cART |
| title_fullStr | Monocytes as Regulators of Inflammation and HIV-Related Comorbidities during cART |
| title_full_unstemmed | Monocytes as Regulators of Inflammation and HIV-Related Comorbidities during cART |
| title_short | Monocytes as Regulators of Inflammation and HIV-Related Comorbidities during cART |
| title_sort | monocytes as regulators of inflammation and hiv related comorbidities during cart |
| url | http://dx.doi.org/10.1155/2014/569819 |
| work_keys_str_mv | AT joshuajanzinger monocytesasregulatorsofinflammationandhivrelatedcomorbiditiesduringcart AT tiffanyrbutterfield monocytesasregulatorsofinflammationandhivrelatedcomorbiditiesduringcart AT thomasaangelovich monocytesasregulatorsofinflammationandhivrelatedcomorbiditiesduringcart AT suzannemcrowe monocytesasregulatorsofinflammationandhivrelatedcomorbiditiesduringcart AT clovisspalmer monocytesasregulatorsofinflammationandhivrelatedcomorbiditiesduringcart |