Assessment of Quadriceps Muscle Strength and Thickness in Adolescents with Polycystic Ovary Syndrome: A Case-control and Longitudinal Follow-up Study
Objective: To date, muscle strength and thickness have not been investigated in adolescents with polycystic ovary syndrome (PCOS). This study aimed to investigate whether differences exist in these parameters between adolescents with PCOS and healthy controls. Additionally, we evaluated the effects...
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| Format: | Article |
| Language: | English |
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Galenos Yayincilik
2025-06-01
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| Series: | JCRPE |
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| Online Access: | https://www.jcrpe.org/articles/assessment-of-quadriceps-muscle-strength-and-thickness-in-adolescents-with-polycystic-ovary-syndrome-a-case-control-and-longitudinal-follow-up-study/doi/jcrpe.galenos.2025.2024-12-5 |
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| author | Ayşe Gül Güven Murat Kara Sinem Güneri Demet Aygün Arı Erdem Karabulut Hüseyin Demirbilek Gürkan Bozdağ Orhan Derman |
| author_facet | Ayşe Gül Güven Murat Kara Sinem Güneri Demet Aygün Arı Erdem Karabulut Hüseyin Demirbilek Gürkan Bozdağ Orhan Derman |
| author_sort | Ayşe Gül Güven |
| collection | DOAJ |
| description | Objective: To date, muscle strength and thickness have not been investigated in adolescents with polycystic ovary syndrome (PCOS). This study aimed to investigate whether differences exist in these parameters between adolescents with PCOS and healthy controls. Additionally, we evaluated the effects of six months combined oral contraceptive (COC) treatment on quadriceps muscle characteristics.
Methods: The study included adolescents diagnosed with PCOS and healthy peers. Dynamometers were used to measure knee muscle and hand grip strengths, and ultrasound was used to measure quadriceps muscle thickness. In the PCOS group, all measurements were repeated after six months of COCs treatment.
Results: There were 20 participants in each of the PCOS and control groups. There were no significant differences between the groups in terms of age, weight, height, pubertal stage, Physical Activity Questionnaire scores, quadriceps muscle thickness, grip strength and isokinetic knee strengths at baseline. Within the PCOS group, significant increase were observed in weight, height, quadriceps strength and lipid levels after six months of treatment (all p<0.05). Subgroup analysis of COC treatments revealed significantly greater gains in quadriceps muscle strength among levonorgestrel users (n=6) compared to those using cyproterone acetate users (n=13).
Conclusion: Quadriceps muscle thickness and strength were comparable between adolescent with PCOS and controls, indicating no intrinsic muscular deficit. However, significantly greater improvements in quadriceps muscle strength were observed in those using levonorgestrel-containing COCs users compared to cyproterone acetate users. These findings suggest a potential role of progestin androgenicity in muscle strength. Further longitudinal studies with larger cohorts are warranted to validate these preliminary findings and to explore the impact of COCs with varying androgenic properties. |
| format | Article |
| id | doaj-art-8d8e2b1cc2e74929b8d5bc6b70bc2b07 |
| institution | Kabale University |
| issn | 1308-5727 1308-5735 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Galenos Yayincilik |
| record_format | Article |
| series | JCRPE |
| spelling | doaj-art-8d8e2b1cc2e74929b8d5bc6b70bc2b072025-08-20T03:46:42ZengGalenos YayincilikJCRPE1308-57271308-57352025-06-0117220221010.4274/jcrpe.galenos.2025.2024-12-5Assessment of Quadriceps Muscle Strength and Thickness in Adolescents with Polycystic Ovary Syndrome: A Case-control and Longitudinal Follow-up StudyAyşe Gül Güven0https://orcid.org/0000-0003-3129-4315Murat Kara1https://orcid.org/0000-0003-0125-4865Sinem Güneri2https://orcid.org/0000-0003-4171-9786Demet Aygün Arı3https://orcid.org/0000-0002-8701-6085Erdem Karabulut4https://orcid.org/0000-0002-7811-8215Hüseyin Demirbilek5https://orcid.org/0000-0001-6374-5884Gürkan Bozdağ6https://orcid.org/0000-0002-6679-9623Orhan Derman7https://orcid.org/0000-0003-4618-1110Hacettepe University Faculty of Medicine, Department of Pediatrics, Clinic of Adolescent Medicine, Ankara, TürkiyeHacettepe University Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Ankara, TürkiyeHacettepe University Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Ankara, TürkiyeHacettepe University Faculty of Medicine, Department of Pediatrics, Clinic of Adolescent Medicine, Ankara, TürkiyeHacettepe University Faculty of Medicine, Department of Biostatistics, Ankara, TürkiyeHacettepe University Faculty of Medicine, Department of Pediatrics, Clinic of Pediatric Endocrinology, Ankara, TürkiyeHacettepe University Faculty of Medicine, Department of Obstetrics and Gynecology, Ankara, TürkiyeHacettepe University Faculty of Medicine, Department of Pediatrics, Clinic of Adolescent Medicine, Ankara, TürkiyeObjective: To date, muscle strength and thickness have not been investigated in adolescents with polycystic ovary syndrome (PCOS). This study aimed to investigate whether differences exist in these parameters between adolescents with PCOS and healthy controls. Additionally, we evaluated the effects of six months combined oral contraceptive (COC) treatment on quadriceps muscle characteristics. Methods: The study included adolescents diagnosed with PCOS and healthy peers. Dynamometers were used to measure knee muscle and hand grip strengths, and ultrasound was used to measure quadriceps muscle thickness. In the PCOS group, all measurements were repeated after six months of COCs treatment. Results: There were 20 participants in each of the PCOS and control groups. There were no significant differences between the groups in terms of age, weight, height, pubertal stage, Physical Activity Questionnaire scores, quadriceps muscle thickness, grip strength and isokinetic knee strengths at baseline. Within the PCOS group, significant increase were observed in weight, height, quadriceps strength and lipid levels after six months of treatment (all p<0.05). Subgroup analysis of COC treatments revealed significantly greater gains in quadriceps muscle strength among levonorgestrel users (n=6) compared to those using cyproterone acetate users (n=13). Conclusion: Quadriceps muscle thickness and strength were comparable between adolescent with PCOS and controls, indicating no intrinsic muscular deficit. However, significantly greater improvements in quadriceps muscle strength were observed in those using levonorgestrel-containing COCs users compared to cyproterone acetate users. These findings suggest a potential role of progestin androgenicity in muscle strength. Further longitudinal studies with larger cohorts are warranted to validate these preliminary findings and to explore the impact of COCs with varying androgenic properties.https://www.jcrpe.org/articles/assessment-of-quadriceps-muscle-strength-and-thickness-in-adolescents-with-polycystic-ovary-syndrome-a-case-control-and-longitudinal-follow-up-study/doi/jcrpe.galenos.2025.2024-12-5pcosisokineticultrasoundlevonorgestreloral contraceptive |
| spellingShingle | Ayşe Gül Güven Murat Kara Sinem Güneri Demet Aygün Arı Erdem Karabulut Hüseyin Demirbilek Gürkan Bozdağ Orhan Derman Assessment of Quadriceps Muscle Strength and Thickness in Adolescents with Polycystic Ovary Syndrome: A Case-control and Longitudinal Follow-up Study JCRPE pcos isokinetic ultrasound levonorgestrel oral contraceptive |
| title | Assessment of Quadriceps Muscle Strength and Thickness in Adolescents with Polycystic Ovary Syndrome: A Case-control and Longitudinal Follow-up Study |
| title_full | Assessment of Quadriceps Muscle Strength and Thickness in Adolescents with Polycystic Ovary Syndrome: A Case-control and Longitudinal Follow-up Study |
| title_fullStr | Assessment of Quadriceps Muscle Strength and Thickness in Adolescents with Polycystic Ovary Syndrome: A Case-control and Longitudinal Follow-up Study |
| title_full_unstemmed | Assessment of Quadriceps Muscle Strength and Thickness in Adolescents with Polycystic Ovary Syndrome: A Case-control and Longitudinal Follow-up Study |
| title_short | Assessment of Quadriceps Muscle Strength and Thickness in Adolescents with Polycystic Ovary Syndrome: A Case-control and Longitudinal Follow-up Study |
| title_sort | assessment of quadriceps muscle strength and thickness in adolescents with polycystic ovary syndrome a case control and longitudinal follow up study |
| topic | pcos isokinetic ultrasound levonorgestrel oral contraceptive |
| url | https://www.jcrpe.org/articles/assessment-of-quadriceps-muscle-strength-and-thickness-in-adolescents-with-polycystic-ovary-syndrome-a-case-control-and-longitudinal-follow-up-study/doi/jcrpe.galenos.2025.2024-12-5 |
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