Mechanisms of sterilizing immunity provided by an HIV-1 neutralizing antibody against mucosal infection.

Broadly neutralizing antibodies (bnAbs) against HIV-1 have been shown to protect from systemic infection. When employing a novel challenge virus that uses HIV-1 Env for entry into target cells during the first replication cycle, but then switches to SIV Env usage, we demonstrated that bnAbs also pre...

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Main Authors: Elie Richel, Arne Cordsmeier, Larissa Bauer, Kirsten Fraedrich, Ramona Vestweber, Berit Roshani, Nicole Stolte-Leeb, Armin Ensser, Christiane Stahl-Hennig, Klaus Überla
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-12-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1012777
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