Antibody association in solution: cluster distributions and mechanisms

Antibody association in solution: cluster distributions and mechanisms

Understanding factors that affect the clustering and association of antibodies molecules in solution is critical to their development as therapeutics. For 19 different monoclonal antibody (mAb) solutions, we measured the viscosities, the second virial coefficients, the Kirkwood-Buff integrals, and t...

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Bibliographic Details
Main Authors: Sandi Brudar, Leonid Breydo, Elisha Chung, Ken A. Dill, Nasim Ehterami, Ketan Phadnis, Samir Senapati, Mohammed Shameem, Xiaolin Tang, Muhammmad Tayyab, Barbara Hribar-Lee
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:mAbs
Subjects:
Aggregation
viscosity
G22
modeling
thermodynamic perturbation theory
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2024.2339582
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