Transcription factor KLF2 is associated with the dysfunctional status of NK cells and the prognosis of pediatric B-ALL patients

Transcription factor KLF2 is associated with the dysfunctional status of NK cells and the prognosis of pediatric B-ALL patients

BackgroundNatural killer cells, an important component of the innate immune system, can directly recognize and lyse virally infected or transformed cells. However, NK cells fail to restrain the growth of malignancies, such as B-cell acute lymphoblastic leukemia (B-ALL). The molecular genetics of NK...

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Bibliographic Details
Main Authors: Fang Wu, Huimin Xu, Benshan Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Oncology
Subjects:
NK cells
KLF2
proliferation
pediatric B-ALL
therapeutic response
prognosis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2024.1456004/full
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