Effects of Fish Oil (SMOFlipid<sup>®</sup>) and Olive Oil Lipid (ClinOleic<sup>®</sup>) on Neonatal Morbidities in Preterm Infants
Objective: Total parenteral nutrition (TPN) is very important for providing optimal nutrition during the critical developmental period of preterm newborns. Thus, there is a need to optimize TPN solutions to reduce morbidities. This study aimed to examine the effects of olive oil (ClinOleic®) and fis...
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Galenos Publishing House
2022-09-01
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| Series: | Medeniyet Medical Journal |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=medeniyet&un=MEDJ-83548 |
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| author | Fatih KILICBAY Aslı KESKIN Ayla GUNLEMEZ |
| author_facet | Fatih KILICBAY Aslı KESKIN Ayla GUNLEMEZ |
| author_sort | Fatih KILICBAY |
| collection | DOAJ |
| description | Objective: Total parenteral nutrition (TPN) is very important for providing optimal nutrition during the critical developmental period of preterm newborns. Thus, there is a need to optimize TPN solutions to reduce morbidities. This study aimed to examine the effects of olive oil (ClinOleic®) and fish oil (SMOFlipid®) therapies on the frequencies of neonatal morbidities.
Methods: Premature newborns hospitalized in the neonatal intensive care unit and receiving TPN for at least 14 days were included in the study. Newborns who were hospitalized and received olive oil-based lipid (ClinOleic®) were included in the olive oil group, and those who received omega-3 containing multi-lipid (SMOFlipid®) were included in the SMOFlipid group.
Results: This study enrolled a total of 222 very-low-birth-weight premature newborns. The breastfeeding rate in the olive oil group was significantly lower than that in the SMOFlipid group (p<0.05). The rate of necrotizing entercolitis (NEC) in the olive oil group was significantly higher than that in the SMOFlipid group (p<0.05). The rate of bronchopulmonary dysplasia (BPD) in the SMOFlipid group was lower than that in the olive oil group (p<0.05).
Conclusions: The rates of BPD and NEC were lower in the fish oil group. In this situation, fish oil therapy may provide protection against the development of BPD and NEC. Prospective studies are needed to determine whether this is caused by lipid therapy or an effect of breast milk. |
| format | Article |
| id | doaj-art-8d665640878741278398b6e4d88866f0 |
| institution | Kabale University |
| issn | 2149-2042 2149-4606 |
| language | English |
| publishDate | 2022-09-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Medeniyet Medical Journal |
| spelling | doaj-art-8d665640878741278398b6e4d88866f02025-01-30T07:10:57ZengGalenos Publishing HouseMedeniyet Medical Journal2149-20422149-46062022-09-0137324024710.4274/MMJ.galenos.2022.83548MEDJ-83548Effects of Fish Oil (SMOFlipid<sup>®</sup>) and Olive Oil Lipid (ClinOleic<sup>®</sup>) on Neonatal Morbidities in Preterm InfantsFatih KILICBAY0Aslı KESKIN1Ayla GUNLEMEZ2Sivas Cumhuriyet University Faculty of Medicine, Department of Pediatrics, Division of Neonatology, Sivas, TurkeyBayramic State Hospital, Clinic of Pediatrics, Canakkale, TurkeyKocaeli University Faculty of Medicine, Department of Pediatrics, Division of Neonatology, Kocaeli, TurkeyObjective: Total parenteral nutrition (TPN) is very important for providing optimal nutrition during the critical developmental period of preterm newborns. Thus, there is a need to optimize TPN solutions to reduce morbidities. This study aimed to examine the effects of olive oil (ClinOleic®) and fish oil (SMOFlipid®) therapies on the frequencies of neonatal morbidities. Methods: Premature newborns hospitalized in the neonatal intensive care unit and receiving TPN for at least 14 days were included in the study. Newborns who were hospitalized and received olive oil-based lipid (ClinOleic®) were included in the olive oil group, and those who received omega-3 containing multi-lipid (SMOFlipid®) were included in the SMOFlipid group. Results: This study enrolled a total of 222 very-low-birth-weight premature newborns. The breastfeeding rate in the olive oil group was significantly lower than that in the SMOFlipid group (p<0.05). The rate of necrotizing entercolitis (NEC) in the olive oil group was significantly higher than that in the SMOFlipid group (p<0.05). The rate of bronchopulmonary dysplasia (BPD) in the SMOFlipid group was lower than that in the olive oil group (p<0.05). Conclusions: The rates of BPD and NEC were lower in the fish oil group. In this situation, fish oil therapy may provide protection against the development of BPD and NEC. Prospective studies are needed to determine whether this is caused by lipid therapy or an effect of breast milk.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=medeniyet&un=MEDJ-83548lipid emulsionsparenteral nutritionpremature newbornsmorbidities |
| spellingShingle | Fatih KILICBAY Aslı KESKIN Ayla GUNLEMEZ Effects of Fish Oil (SMOFlipid<sup>®</sup>) and Olive Oil Lipid (ClinOleic<sup>®</sup>) on Neonatal Morbidities in Preterm Infants Medeniyet Medical Journal lipid emulsions parenteral nutrition premature newborns morbidities |
| title | Effects of Fish Oil (SMOFlipid<sup>®</sup>) and Olive Oil Lipid (ClinOleic<sup>®</sup>) on Neonatal Morbidities in Preterm Infants |
| title_full | Effects of Fish Oil (SMOFlipid<sup>®</sup>) and Olive Oil Lipid (ClinOleic<sup>®</sup>) on Neonatal Morbidities in Preterm Infants |
| title_fullStr | Effects of Fish Oil (SMOFlipid<sup>®</sup>) and Olive Oil Lipid (ClinOleic<sup>®</sup>) on Neonatal Morbidities in Preterm Infants |
| title_full_unstemmed | Effects of Fish Oil (SMOFlipid<sup>®</sup>) and Olive Oil Lipid (ClinOleic<sup>®</sup>) on Neonatal Morbidities in Preterm Infants |
| title_short | Effects of Fish Oil (SMOFlipid<sup>®</sup>) and Olive Oil Lipid (ClinOleic<sup>®</sup>) on Neonatal Morbidities in Preterm Infants |
| title_sort | effects of fish oil smoflipid sup r sup and olive oil lipid clinoleic sup r sup on neonatal morbidities in preterm infants |
| topic | lipid emulsions parenteral nutrition premature newborns morbidities |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=medeniyet&un=MEDJ-83548 |
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