Effect of dual targeting procyanidins nanoparticles on metabolomics of lipopolysaccharide-stimulated inflammatory macrophages
Inflammation plays an important role in the occurrence and development of many inflammatory diseases. The purpose of this study was to evaluate the anti-inflammatory effect and metabolic behavior of the dual targeting procyanidins (PC) nanoparticles on lipopolysaccharide (LPS)-stimulated inflammator...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2023-11-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453023000976 |
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| author | Shanshan Tie Lijuan Zhang Bin Li Shanghua Xing Haitao Wang Yannan Chen Weina Cui Shaobin Gu Mingqian Tan |
| author_facet | Shanshan Tie Lijuan Zhang Bin Li Shanghua Xing Haitao Wang Yannan Chen Weina Cui Shaobin Gu Mingqian Tan |
| author_sort | Shanshan Tie |
| collection | DOAJ |
| description | Inflammation plays an important role in the occurrence and development of many inflammatory diseases. The purpose of this study was to evaluate the anti-inflammatory effect and metabolic behavior of the dual targeting procyanidins (PC) nanoparticles on lipopolysaccharide (LPS)-stimulated inflammatory macrophages by metabolomics method. The double-targeting PC nanoparticles could specifically target both the CD44 receptor and mitochondria, while the single targeting PC-loaded nanoparticles that could target the CD44 receptor on the surface of macrophages. The double-targeting PC nanoparticles had better inhibitory effect than single-targeting PC nanoparticles on the leakage of lactate dehydrogenase and reactive oxygen species overexpression induced by LPS. Amino acid metabolism, energy metabolism and purine metabolism were disordered in LPS-treated group, and metabolic pathway analysis indicated that the double-targeting PC nanoparticles reversed some of LPS impacts. The changes of these potential biomarkers and their corresponding pathways are helpful to further understand the mechanism of PC nanoparticles in alleviating inflammation, and promote their application in nutrition intervention. |
| format | Article |
| id | doaj-art-8d65a71fcf014423ad69485d833be81e |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2023-11-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-8d65a71fcf014423ad69485d833be81e2025-02-03T05:55:57ZengTsinghua University PressFood Science and Human Wellness2213-45302023-11-0112622522262Effect of dual targeting procyanidins nanoparticles on metabolomics of lipopolysaccharide-stimulated inflammatory macrophagesShanshan Tie0Lijuan Zhang1Bin Li2Shanghua Xing3Haitao Wang4Yannan Chen5Weina Cui6Shaobin Gu7Mingqian Tan8Academy of Food Interdisciplinary Science, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China; College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471023, ChinaAcademy of Food Interdisciplinary Science, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, ChinaCollege of Food Science, Shenyang Agricultural University, National R&D Professional Center for Berry Processing, Liaoning Province, Shenyang 110866, ChinaAcademy of Food Interdisciplinary Science, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, ChinaAcademy of Food Interdisciplinary Science, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, ChinaAcademy of Food Interdisciplinary Science, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, ChinaAcademy of Food Interdisciplinary Science, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, ChinaCollege of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471023, ChinaAcademy of Food Interdisciplinary Science, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China; Corresponding author at: Academy of Food Interdisciplinary Science, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China.Inflammation plays an important role in the occurrence and development of many inflammatory diseases. The purpose of this study was to evaluate the anti-inflammatory effect and metabolic behavior of the dual targeting procyanidins (PC) nanoparticles on lipopolysaccharide (LPS)-stimulated inflammatory macrophages by metabolomics method. The double-targeting PC nanoparticles could specifically target both the CD44 receptor and mitochondria, while the single targeting PC-loaded nanoparticles that could target the CD44 receptor on the surface of macrophages. The double-targeting PC nanoparticles had better inhibitory effect than single-targeting PC nanoparticles on the leakage of lactate dehydrogenase and reactive oxygen species overexpression induced by LPS. Amino acid metabolism, energy metabolism and purine metabolism were disordered in LPS-treated group, and metabolic pathway analysis indicated that the double-targeting PC nanoparticles reversed some of LPS impacts. The changes of these potential biomarkers and their corresponding pathways are helpful to further understand the mechanism of PC nanoparticles in alleviating inflammation, and promote their application in nutrition intervention.http://www.sciencedirect.com/science/article/pii/S2213453023000976Procyanidins nanoparticlesMetabolomicsInflammationMacrophagesLipopolysaccharide |
| spellingShingle | Shanshan Tie Lijuan Zhang Bin Li Shanghua Xing Haitao Wang Yannan Chen Weina Cui Shaobin Gu Mingqian Tan Effect of dual targeting procyanidins nanoparticles on metabolomics of lipopolysaccharide-stimulated inflammatory macrophages Food Science and Human Wellness Procyanidins nanoparticles Metabolomics Inflammation Macrophages Lipopolysaccharide |
| title | Effect of dual targeting procyanidins nanoparticles on metabolomics of lipopolysaccharide-stimulated inflammatory macrophages |
| title_full | Effect of dual targeting procyanidins nanoparticles on metabolomics of lipopolysaccharide-stimulated inflammatory macrophages |
| title_fullStr | Effect of dual targeting procyanidins nanoparticles on metabolomics of lipopolysaccharide-stimulated inflammatory macrophages |
| title_full_unstemmed | Effect of dual targeting procyanidins nanoparticles on metabolomics of lipopolysaccharide-stimulated inflammatory macrophages |
| title_short | Effect of dual targeting procyanidins nanoparticles on metabolomics of lipopolysaccharide-stimulated inflammatory macrophages |
| title_sort | effect of dual targeting procyanidins nanoparticles on metabolomics of lipopolysaccharide stimulated inflammatory macrophages |
| topic | Procyanidins nanoparticles Metabolomics Inflammation Macrophages Lipopolysaccharide |
| url | http://www.sciencedirect.com/science/article/pii/S2213453023000976 |
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