In vitro antioxidant and antityrosinase activities of Manilkara kauki
Manilkara kauki L. Dubard is a tropical plant in the genus Manilkara of family Sapotaceae. This study investigated the total phenolic and flavonoid contents, and antioxidant and antityrosinase activities in different parts of M. kauki (fruits, leaves, seeds, stem barks and woods) and in fractions of...
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| Language: | English |
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2021-03-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2021-0009 |
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| author | Srisupap Sirinada Chaicharoenpong Chanya |
| author_facet | Srisupap Sirinada Chaicharoenpong Chanya |
| author_sort | Srisupap Sirinada |
| collection | DOAJ |
| description | Manilkara kauki L. Dubard is a tropical plant in the genus Manilkara of family Sapotaceae. This study investigated the total phenolic and flavonoid contents, and antioxidant and antityrosinase activities in different parts of M. kauki (fruits, leaves, seeds, stem barks and woods) and in fractions of stem barks. The total phenolic and flavonoid contents of the methanol and aqueous crude extracts of different parts of M. kauki ranged from 10.87 to 176.56 mg GAE (gallic acid equivalents) per gram of crude extract and 14.33 to 821.67 mg QE (quercetin equivalents) per gram of crude extract, resp. Leaves and stem barks exhibited higher total phenolic and flavonoid contents and antioxidant and anti-tyrosinase activities than fruits, seeds and woods. Stem barks were sequentially extracted with n-hexane, ethyl acetate, methanol and water and then the fractionated extracts were subjected to antioxidant and antityrosinase activities testing. The ethyl acetate and methanol extracts of stem barks exhibited higher total phenolic and flavonoid contents and antioxidant and antityrosinase activities than the n-hexane and aqueous extracts. Moreover, ethyl acetate extract of M. kauki stem exhibited the highest antityrosinase activity. It may be a potential source of tyrosinase inhibitors for pharmaceutical and cosmetic applications. |
| format | Article |
| id | doaj-art-8d5c0ddffedc466d88ea53d85b3a7011 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2021-03-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-8d5c0ddffedc466d88ea53d85b3a70112025-02-02T00:31:54ZengSciendoActa Pharmaceutica1846-95582021-03-0171115316210.2478/acph-2021-0009acph-2021-0009In vitro antioxidant and antityrosinase activities of Manilkara kaukiSrisupap Sirinada0Chaicharoenpong Chanya1Program in Biotechnology, Faculty of Science, Chulalongkorn UniversityBangkok10330, ThailandInstitute of Biotechnology and Genetic Engineering, Chulalongkorn UniversityBangkok10330, ThailandManilkara kauki L. Dubard is a tropical plant in the genus Manilkara of family Sapotaceae. This study investigated the total phenolic and flavonoid contents, and antioxidant and antityrosinase activities in different parts of M. kauki (fruits, leaves, seeds, stem barks and woods) and in fractions of stem barks. The total phenolic and flavonoid contents of the methanol and aqueous crude extracts of different parts of M. kauki ranged from 10.87 to 176.56 mg GAE (gallic acid equivalents) per gram of crude extract and 14.33 to 821.67 mg QE (quercetin equivalents) per gram of crude extract, resp. Leaves and stem barks exhibited higher total phenolic and flavonoid contents and antioxidant and anti-tyrosinase activities than fruits, seeds and woods. Stem barks were sequentially extracted with n-hexane, ethyl acetate, methanol and water and then the fractionated extracts were subjected to antioxidant and antityrosinase activities testing. The ethyl acetate and methanol extracts of stem barks exhibited higher total phenolic and flavonoid contents and antioxidant and antityrosinase activities than the n-hexane and aqueous extracts. Moreover, ethyl acetate extract of M. kauki stem exhibited the highest antityrosinase activity. It may be a potential source of tyrosinase inhibitors for pharmaceutical and cosmetic applications.https://doi.org/10.2478/acph-2021-0009manilkara kaukitotal phenolic contenttotal flavonoid contentantioxidanttyrosinase inhibitor |
| spellingShingle | Srisupap Sirinada Chaicharoenpong Chanya In vitro antioxidant and antityrosinase activities of Manilkara kauki Acta Pharmaceutica manilkara kauki total phenolic content total flavonoid content antioxidant tyrosinase inhibitor |
| title | In vitro antioxidant and antityrosinase activities of Manilkara kauki |
| title_full | In vitro antioxidant and antityrosinase activities of Manilkara kauki |
| title_fullStr | In vitro antioxidant and antityrosinase activities of Manilkara kauki |
| title_full_unstemmed | In vitro antioxidant and antityrosinase activities of Manilkara kauki |
| title_short | In vitro antioxidant and antityrosinase activities of Manilkara kauki |
| title_sort | in vitro antioxidant and antityrosinase activities of manilkara kauki |
| topic | manilkara kauki total phenolic content total flavonoid content antioxidant tyrosinase inhibitor |
| url | https://doi.org/10.2478/acph-2021-0009 |
| work_keys_str_mv | AT srisupapsirinada invitroantioxidantandantityrosinaseactivitiesofmanilkarakauki AT chaicharoenpongchanya invitroantioxidantandantityrosinaseactivitiesofmanilkarakauki |