Surgical Treatment of Sporadic Pancreatic Neuroendocrine Tumors: A State of the Art Review
Pancreatic neuroendocrine tumors (PNETs) are rare neoplasms. They are clinically diverse and divided into functioning and nonfunctioning disease, depending on their ability to produce symptoms due to hormone production. Surgical resection is the only curative treatment and remains the cornerstone th...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/357475 |
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| author | Sven-Petter Haugvik Knut Jørgen Labori Bjørn Edwin Øystein Mathisen Ivar Prydz Gladhaug |
| author_facet | Sven-Petter Haugvik Knut Jørgen Labori Bjørn Edwin Øystein Mathisen Ivar Prydz Gladhaug |
| author_sort | Sven-Petter Haugvik |
| collection | DOAJ |
| description | Pancreatic neuroendocrine tumors (PNETs) are rare neoplasms. They are clinically diverse and divided into functioning and nonfunctioning disease, depending on their ability to produce symptoms due to hormone production. Surgical resection is the only curative treatment and remains the cornerstone therapy for this patient group, even in patients with advanced disease. Over the last decade there has been a noticeable trend towards more aggressive surgery as well as more minimally invasive surgery in patients with PNETs. This has resulted in improved long-term survival in patients with locally advanced and metastatic disease treated aggressively, as well as shorter hospital stays and comparable long-term outcomes in patients with limited disease treated minimally invasively. There are still controversies related to issues of surgical treatment of PNETs, such as to what extent enucleation, lymph node sampling, and vascular reconstruction are beneficial for the oncologic outcome. Histopathologic tumor classification is of high clinical importance for treatment planning and prognostic evaluation of patients with PNETs. A constant challenge, which relates to the treatment of PNETs, is the lack of an internationally accepted histopathological classification system. This paper reviews current issues on the surgical treatment of sporadic PNETs with specific focus on surgical approaches and tumor classification. |
| format | Article |
| id | doaj-art-8d5790ea2c084f50b8a9ac425c2e6e04 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-8d5790ea2c084f50b8a9ac425c2e6e042025-02-03T06:47:54ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/357475357475Surgical Treatment of Sporadic Pancreatic Neuroendocrine Tumors: A State of the Art ReviewSven-Petter Haugvik0Knut Jørgen Labori1Bjørn Edwin2Øystein Mathisen3Ivar Prydz Gladhaug4Department of Hepato-Pancreato-Biliary Surgery, Rikshospitalet, Oslo University Hospital, Sognsvannsveien 20, 0372 Oslo, NorwayDepartment of Hepato-Pancreato-Biliary Surgery, Rikshospitalet, Oslo University Hospital, Sognsvannsveien 20, 0372 Oslo, NorwayDepartment of Hepato-Pancreato-Biliary Surgery, Rikshospitalet, Oslo University Hospital, Sognsvannsveien 20, 0372 Oslo, NorwayDepartment of Hepato-Pancreato-Biliary Surgery, Rikshospitalet, Oslo University Hospital, Sognsvannsveien 20, 0372 Oslo, NorwayDepartment of Hepato-Pancreato-Biliary Surgery, Rikshospitalet, Oslo University Hospital, Sognsvannsveien 20, 0372 Oslo, NorwayPancreatic neuroendocrine tumors (PNETs) are rare neoplasms. They are clinically diverse and divided into functioning and nonfunctioning disease, depending on their ability to produce symptoms due to hormone production. Surgical resection is the only curative treatment and remains the cornerstone therapy for this patient group, even in patients with advanced disease. Over the last decade there has been a noticeable trend towards more aggressive surgery as well as more minimally invasive surgery in patients with PNETs. This has resulted in improved long-term survival in patients with locally advanced and metastatic disease treated aggressively, as well as shorter hospital stays and comparable long-term outcomes in patients with limited disease treated minimally invasively. There are still controversies related to issues of surgical treatment of PNETs, such as to what extent enucleation, lymph node sampling, and vascular reconstruction are beneficial for the oncologic outcome. Histopathologic tumor classification is of high clinical importance for treatment planning and prognostic evaluation of patients with PNETs. A constant challenge, which relates to the treatment of PNETs, is the lack of an internationally accepted histopathological classification system. This paper reviews current issues on the surgical treatment of sporadic PNETs with specific focus on surgical approaches and tumor classification.http://dx.doi.org/10.1100/2012/357475 |
| spellingShingle | Sven-Petter Haugvik Knut Jørgen Labori Bjørn Edwin Øystein Mathisen Ivar Prydz Gladhaug Surgical Treatment of Sporadic Pancreatic Neuroendocrine Tumors: A State of the Art Review The Scientific World Journal |
| title | Surgical Treatment of Sporadic Pancreatic Neuroendocrine Tumors: A State of the Art Review |
| title_full | Surgical Treatment of Sporadic Pancreatic Neuroendocrine Tumors: A State of the Art Review |
| title_fullStr | Surgical Treatment of Sporadic Pancreatic Neuroendocrine Tumors: A State of the Art Review |
| title_full_unstemmed | Surgical Treatment of Sporadic Pancreatic Neuroendocrine Tumors: A State of the Art Review |
| title_short | Surgical Treatment of Sporadic Pancreatic Neuroendocrine Tumors: A State of the Art Review |
| title_sort | surgical treatment of sporadic pancreatic neuroendocrine tumors a state of the art review |
| url | http://dx.doi.org/10.1100/2012/357475 |
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