Transcriptional Control of Synaptic Plasticity by Transcription Factor NF-κB
Activation of nuclear factor kappa B (NF-κB) transcription factors is required for the induction of synaptic plasticity and memory formation. All components of this signaling pathway are localized at synapses, and transcriptionally active NF-κB dimers move to the nucleus to translate synaptic signal...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2016/7027949 |
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| _version_ | 1832556481697808384 |
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| author | Christian Engelmann Ronny Haenold |
| author_facet | Christian Engelmann Ronny Haenold |
| author_sort | Christian Engelmann |
| collection | DOAJ |
| description | Activation of nuclear factor kappa B (NF-κB) transcription factors is required for the induction of synaptic plasticity and memory formation. All components of this signaling pathway are localized at synapses, and transcriptionally active NF-κB dimers move to the nucleus to translate synaptic signals into altered gene expression. Neuron-specific inhibition results in altered connectivity of excitatory and inhibitory synapses and functionally in selective learning deficits. Recent research on transgenic mice with impaired or hyperactivated NF-κB gave important insights into plasticity-related target gene expression that is regulated by NF-κB. In this minireview, we update the available data on the role of this transcription factor for learning and memory formation and comment on cross-sectional activation of NF-κB in the aged and diseased brain that may directly or indirectly affect κB-dependent transcription of synaptic genes. |
| format | Article |
| id | doaj-art-8d503e250cb14dd38c3a2b79a599d987 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-8d503e250cb14dd38c3a2b79a599d9872025-02-03T05:45:15ZengWileyNeural Plasticity2090-59041687-54432016-01-01201610.1155/2016/70279497027949Transcriptional Control of Synaptic Plasticity by Transcription Factor NF-κBChristian Engelmann0Ronny Haenold1Leibniz Institute on Aging-Fritz Lipmann Institute (FLI), Beutenbergstrasse 11, 07745 Jena, GermanyLeibniz Institute on Aging-Fritz Lipmann Institute (FLI), Beutenbergstrasse 11, 07745 Jena, GermanyActivation of nuclear factor kappa B (NF-κB) transcription factors is required for the induction of synaptic plasticity and memory formation. All components of this signaling pathway are localized at synapses, and transcriptionally active NF-κB dimers move to the nucleus to translate synaptic signals into altered gene expression. Neuron-specific inhibition results in altered connectivity of excitatory and inhibitory synapses and functionally in selective learning deficits. Recent research on transgenic mice with impaired or hyperactivated NF-κB gave important insights into plasticity-related target gene expression that is regulated by NF-κB. In this minireview, we update the available data on the role of this transcription factor for learning and memory formation and comment on cross-sectional activation of NF-κB in the aged and diseased brain that may directly or indirectly affect κB-dependent transcription of synaptic genes.http://dx.doi.org/10.1155/2016/7027949 |
| spellingShingle | Christian Engelmann Ronny Haenold Transcriptional Control of Synaptic Plasticity by Transcription Factor NF-κB Neural Plasticity |
| title | Transcriptional Control of Synaptic Plasticity by Transcription Factor NF-κB |
| title_full | Transcriptional Control of Synaptic Plasticity by Transcription Factor NF-κB |
| title_fullStr | Transcriptional Control of Synaptic Plasticity by Transcription Factor NF-κB |
| title_full_unstemmed | Transcriptional Control of Synaptic Plasticity by Transcription Factor NF-κB |
| title_short | Transcriptional Control of Synaptic Plasticity by Transcription Factor NF-κB |
| title_sort | transcriptional control of synaptic plasticity by transcription factor nf κb |
| url | http://dx.doi.org/10.1155/2016/7027949 |
| work_keys_str_mv | AT christianengelmann transcriptionalcontrolofsynapticplasticitybytranscriptionfactornfkb AT ronnyhaenold transcriptionalcontrolofsynapticplasticitybytranscriptionfactornfkb |