Translational Science in Vascular Aging: From Bench to Bedside—Insights from a VascAgeNet Roundtable
Abstract Translating vascular aging research from bench to bedside presents both significant opportunities and challenges. This paper summarizes insights from a roundtable discussion at the Artery 23 conference, featuring perspectives from basic science, clinical trials, regulation, and industry. Th...
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| Format: | Article |
| Language: | English |
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BMC
2024-09-01
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| Series: | Artery Research |
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| Online Access: | https://doi.org/10.1007/s44200-024-00061-9 |
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| author | Elisabetta Bianchini Lynn Roth Pierre Boutouyrie Smriti Badhwar Achim Schwarz Vincenzo Gemignani Rosa Maria Bruno Bernhard Hametner Chloe Park Giacomo Pucci Ioana Mozos Dimitrios Terentes-Printzios Rachel E. Climie Andrea Guala Jordi Alastruey Christopher C. Mayer |
| author_facet | Elisabetta Bianchini Lynn Roth Pierre Boutouyrie Smriti Badhwar Achim Schwarz Vincenzo Gemignani Rosa Maria Bruno Bernhard Hametner Chloe Park Giacomo Pucci Ioana Mozos Dimitrios Terentes-Printzios Rachel E. Climie Andrea Guala Jordi Alastruey Christopher C. Mayer |
| author_sort | Elisabetta Bianchini |
| collection | DOAJ |
| description | Abstract Translating vascular aging research from bench to bedside presents both significant opportunities and challenges. This paper summarizes insights from a roundtable discussion at the Artery 23 conference, featuring perspectives from basic science, clinical trials, regulation, and industry. The main conclusions of the discussion are as follows: basic science research must align with clinical relevance, using appropriate animal models and standardized measurement techniques. Pragmatic and registry-based clinical trials offer viable alternatives to traditional randomized controlled trials, facilitating real-world applicability. The regulatory landscape, particularly for software medical devices, must evolve to keep pace with technological advancements like artificial intelligence. Industry efforts focus on developing devices or solutions for vascular aging assessment and treatment strategies, yet face hurdles in large-scale adoption and reimbursement. Despite significant progress, the development of pharmacological interventions to mitigate vascular aging remains a critical need. This discussion underscores the importance of interdisciplinary collaboration to overcome barriers and translate scientific discoveries into clinical practice effectively. |
| format | Article |
| id | doaj-art-8d44e4319d774384bad0520ec448c890 |
| institution | Kabale University |
| issn | 1876-4401 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Artery Research |
| spelling | doaj-art-8d44e4319d774384bad0520ec448c8902025-02-02T12:14:44ZengBMCArtery Research1876-44012024-09-013011810.1007/s44200-024-00061-9Translational Science in Vascular Aging: From Bench to Bedside—Insights from a VascAgeNet RoundtableElisabetta Bianchini0Lynn Roth1Pierre Boutouyrie2Smriti Badhwar3Achim Schwarz4Vincenzo Gemignani5Rosa Maria Bruno6Bernhard Hametner7Chloe Park8Giacomo Pucci9Ioana Mozos10Dimitrios Terentes-Printzios11Rachel E. Climie12Andrea Guala13Jordi Alastruey14Christopher C. Mayer15Institute of Clinical Physiology (IFC), National Research Council (CNR)Laboratory of Physiopharmacology, University of AntwerpParis Cardiovascular Research Center (PARCC), Université Paris Cité, InsermParis Cardiovascular Research Center (PARCC), Université Paris Cité, InsermALF Distribution GmbHInstitute of Clinical Physiology (IFC), National Research Council (CNR)Paris Cardiovascular Research Center (PARCC), Université Paris Cité, InsermMedical Signal Analysis, AIT Austrian Institute of Technology GmbH, Center for Health & BioresourcesUniversity College London (UCL)Department of Medicine and Surgery, Unit of Internal Medicine, University of Perugia, Terni University HospitalDepartment of Functional Sciences-Pathophysiology, Center for Translational Research and Systems Medicine, Victor Babes University of Medicine and PharmacyFirst Department of Cardiology, Medical School, National and Kapodistrian University of Athens, Hippokration HospitalUniversity of Tasmania, Menzies Institute for Medical ResearchVall d’Hebron Institut de Recerca (VHIR)School of Biomedical Engineering and Imaging Sciences, Department of Biomedical Engineering, King’s College LondonMedical Signal Analysis, AIT Austrian Institute of Technology GmbH, Center for Health & BioresourcesAbstract Translating vascular aging research from bench to bedside presents both significant opportunities and challenges. This paper summarizes insights from a roundtable discussion at the Artery 23 conference, featuring perspectives from basic science, clinical trials, regulation, and industry. The main conclusions of the discussion are as follows: basic science research must align with clinical relevance, using appropriate animal models and standardized measurement techniques. Pragmatic and registry-based clinical trials offer viable alternatives to traditional randomized controlled trials, facilitating real-world applicability. The regulatory landscape, particularly for software medical devices, must evolve to keep pace with technological advancements like artificial intelligence. Industry efforts focus on developing devices or solutions for vascular aging assessment and treatment strategies, yet face hurdles in large-scale adoption and reimbursement. Despite significant progress, the development of pharmacological interventions to mitigate vascular aging remains a critical need. This discussion underscores the importance of interdisciplinary collaboration to overcome barriers and translate scientific discoveries into clinical practice effectively.https://doi.org/10.1007/s44200-024-00061-9Bench to bedsideTranslational scienceVascular aging |
| spellingShingle | Elisabetta Bianchini Lynn Roth Pierre Boutouyrie Smriti Badhwar Achim Schwarz Vincenzo Gemignani Rosa Maria Bruno Bernhard Hametner Chloe Park Giacomo Pucci Ioana Mozos Dimitrios Terentes-Printzios Rachel E. Climie Andrea Guala Jordi Alastruey Christopher C. Mayer Translational Science in Vascular Aging: From Bench to Bedside—Insights from a VascAgeNet Roundtable Artery Research Bench to bedside Translational science Vascular aging |
| title | Translational Science in Vascular Aging: From Bench to Bedside—Insights from a VascAgeNet Roundtable |
| title_full | Translational Science in Vascular Aging: From Bench to Bedside—Insights from a VascAgeNet Roundtable |
| title_fullStr | Translational Science in Vascular Aging: From Bench to Bedside—Insights from a VascAgeNet Roundtable |
| title_full_unstemmed | Translational Science in Vascular Aging: From Bench to Bedside—Insights from a VascAgeNet Roundtable |
| title_short | Translational Science in Vascular Aging: From Bench to Bedside—Insights from a VascAgeNet Roundtable |
| title_sort | translational science in vascular aging from bench to bedside insights from a vascagenet roundtable |
| topic | Bench to bedside Translational science Vascular aging |
| url | https://doi.org/10.1007/s44200-024-00061-9 |
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