A mathematical model for within-host Toxoplasma gondii invasion dynamics
Toxoplasma gondii (T. gondii) is a protozoan parasite thatinfects a wide range of intermediate hosts, including all mammals and birds.Up to 20% of the human population in the US and 30% in the world arechronically infected. This paper presents a mathematical model to describeintra-host dynamics of T...
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| Format: | Article |
| Language: | English |
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AIMS Press
2012-06-01
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| Series: | Mathematical Biosciences and Engineering |
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| Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2012.9.647 |
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| author | Adam Sullivan Folashade Agusto Sharon Bewick Chunlei Su Suzanne Lenhart Xiaopeng Zhao |
| author_facet | Adam Sullivan Folashade Agusto Sharon Bewick Chunlei Su Suzanne Lenhart Xiaopeng Zhao |
| author_sort | Adam Sullivan |
| collection | DOAJ |
| description | Toxoplasma gondii (T. gondii) is a protozoan parasite thatinfects a wide range of intermediate hosts, including all mammals and birds.Up to 20% of the human population in the US and 30% in the world arechronically infected. This paper presents a mathematical model to describeintra-host dynamics of T. gondii infection. The model considers theinvasion process, egress kinetics, interconversion between fast-replicatingtachyzoite stage and slowly replicating bradyzoite stage, as well as thehost's immune response. Analytical and numerical studies of the model can helpto understand the influences of various parameters to the transient andsteady-state dynamics of the disease infection. |
| format | Article |
| id | doaj-art-8d423540096444c086f029c5fd49d2e5 |
| institution | Kabale University |
| issn | 1551-0018 |
| language | English |
| publishDate | 2012-06-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | Mathematical Biosciences and Engineering |
| spelling | doaj-art-8d423540096444c086f029c5fd49d2e52025-01-24T02:07:00ZengAIMS PressMathematical Biosciences and Engineering1551-00182012-06-019364766210.3934/mbe.2012.9.647A mathematical model for within-host Toxoplasma gondii invasion dynamicsAdam Sullivan0Folashade Agusto1Sharon Bewick2Chunlei Su3Suzanne Lenhart4Xiaopeng Zhao5Department of Mechanical, Aerospace, and Biomedical Engineering, University of Tennessee, Knoxville, TN 37996Department of Mechanical, Aerospace, and Biomedical Engineering, University of Tennessee, Knoxville, TN 37996Department of Mechanical, Aerospace, and Biomedical Engineering, University of Tennessee, Knoxville, TN 37996Department of Mechanical, Aerospace, and Biomedical Engineering, University of Tennessee, Knoxville, TN 37996Department of Mechanical, Aerospace, and Biomedical Engineering, University of Tennessee, Knoxville, TN 37996Department of Mechanical, Aerospace, and Biomedical Engineering, University of Tennessee, Knoxville, TN 37996Toxoplasma gondii (T. gondii) is a protozoan parasite thatinfects a wide range of intermediate hosts, including all mammals and birds.Up to 20% of the human population in the US and 30% in the world arechronically infected. This paper presents a mathematical model to describeintra-host dynamics of T. gondii infection. The model considers theinvasion process, egress kinetics, interconversion between fast-replicatingtachyzoite stage and slowly replicating bradyzoite stage, as well as thehost's immune response. Analytical and numerical studies of the model can helpto understand the influences of various parameters to the transient andsteady-state dynamics of the disease infection.https://www.aimspress.com/article/doi/10.3934/mbe.2012.9.647intra-host dynamics.parasite infectionstage conversionwithin-host invasiontoxoplasma gondii |
| spellingShingle | Adam Sullivan Folashade Agusto Sharon Bewick Chunlei Su Suzanne Lenhart Xiaopeng Zhao A mathematical model for within-host Toxoplasma gondii invasion dynamics Mathematical Biosciences and Engineering intra-host dynamics. parasite infection stage conversion within-host invasion toxoplasma gondii |
| title | A mathematical model for within-host Toxoplasma gondii invasion dynamics |
| title_full | A mathematical model for within-host Toxoplasma gondii invasion dynamics |
| title_fullStr | A mathematical model for within-host Toxoplasma gondii invasion dynamics |
| title_full_unstemmed | A mathematical model for within-host Toxoplasma gondii invasion dynamics |
| title_short | A mathematical model for within-host Toxoplasma gondii invasion dynamics |
| title_sort | mathematical model for within host toxoplasma gondii invasion dynamics |
| topic | intra-host dynamics. parasite infection stage conversion within-host invasion toxoplasma gondii |
| url | https://www.aimspress.com/article/doi/10.3934/mbe.2012.9.647 |
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