The Antibacterial Effect of Tinospora Cordifolia (Guduchi) and Its Role in Combating Antimicrobial Resistance
Objective: Tinospora cordifolia, often known as 'Guduchi,' has a variety of medicinal characteristics, including those that are anti-diabetic, antiinflammatory, anti-periodic, anti-arthritic, anti-oxidant, anti-allergic, and anti-stress. Drug development projects face significant obstacles...
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Galenos Publishing House
2023-09-01
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| Series: | Medeniyet Medical Journal |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=medeniyet&un=MEDJ-84579 |
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| author | Kavitha EZHILARASU Anand KASIRANJAN Shanmuga PRIYA Anand KAMARAJ |
| author_facet | Kavitha EZHILARASU Anand KASIRANJAN Shanmuga PRIYA Anand KAMARAJ |
| author_sort | Kavitha EZHILARASU |
| collection | DOAJ |
| description | Objective: Tinospora cordifolia, often known as 'Guduchi,' has a variety of medicinal characteristics, including those that are anti-diabetic, antiinflammatory, anti-periodic, anti-arthritic, anti-oxidant, anti-allergic, and anti-stress. Drug development projects face significant obstacles because of the rapid rise in antimicrobial drug resistance in the world healthcare system and the introduction of multidrug-resistant (MDR) strains. In order to combat the MDR infections isolated from patients' bodies, the current study was conducted to evaluate and investigate the antibacterial capabilities of Tinospora cordifolia. Methods: Using the agar well diffusion method, Tinospora cordifolia extracts (aqueous, chloroform, and ethanol) were tested for their antibacterial effectiveness against 30 MDR pathogens, and the 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyl-tetrazolium bromide assay was used to determine the minimal inhibitory concentration. To determine whether there were any medicinally useful and significant bioactive ingredients in the plant extract, phytochemical analysis was performed. Results: In comparison to the aqueous extract which had little effect, the antibacterial activity of ethanol and chloroform extracts exhibited a potential antimicrobial effect against most of the tested bacterial isolates. Phytochemical analysis of Tinospora cordifolia extract showed alkaloids, carbohydrates, phytosterols, saponins, tannins, proteins, flavonoids, and terpenoids.
Conclusions: Our findings show that Tinospora cordifolia plays a potential role in combating the antimicrobial resistance of clinical isolates. |
| format | Article |
| id | doaj-art-8d388676654048909b6bfa9abfb467b2 |
| institution | Kabale University |
| issn | 2149-2042 2149-4606 |
| language | English |
| publishDate | 2023-09-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Medeniyet Medical Journal |
| spelling | doaj-art-8d388676654048909b6bfa9abfb467b22025-01-30T07:02:58ZengGalenos Publishing HouseMedeniyet Medical Journal2149-20422149-46062023-09-0138314915810.4274/MMJ.galenos.2023.84579MEDJ-84579The Antibacterial Effect of Tinospora Cordifolia (Guduchi) and Its Role in Combating Antimicrobial ResistanceKavitha EZHILARASU0Anand KASIRANJAN1Shanmuga PRIYA2Anand KAMARAJ3Sri Venkateshwraa Medical College Hospital and Research Centre, Department of Microbiology, Pondicherry, IndiaSri Venkateshwraa Medical College Hospital and Research Centre, Department of Microbiology, Pondicherry, IndiaSri Venkateshwraa Medical College Hospital and Research Centre, Department of Microbiology, Pondicherry, IndiaSri Venkateshwraa Medical College Hospital and Research Centre, Department of Microbiology, Pondicherry, IndiaObjective: Tinospora cordifolia, often known as 'Guduchi,' has a variety of medicinal characteristics, including those that are anti-diabetic, antiinflammatory, anti-periodic, anti-arthritic, anti-oxidant, anti-allergic, and anti-stress. Drug development projects face significant obstacles because of the rapid rise in antimicrobial drug resistance in the world healthcare system and the introduction of multidrug-resistant (MDR) strains. In order to combat the MDR infections isolated from patients' bodies, the current study was conducted to evaluate and investigate the antibacterial capabilities of Tinospora cordifolia. Methods: Using the agar well diffusion method, Tinospora cordifolia extracts (aqueous, chloroform, and ethanol) were tested for their antibacterial effectiveness against 30 MDR pathogens, and the 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyl-tetrazolium bromide assay was used to determine the minimal inhibitory concentration. To determine whether there were any medicinally useful and significant bioactive ingredients in the plant extract, phytochemical analysis was performed. Results: In comparison to the aqueous extract which had little effect, the antibacterial activity of ethanol and chloroform extracts exhibited a potential antimicrobial effect against most of the tested bacterial isolates. Phytochemical analysis of Tinospora cordifolia extract showed alkaloids, carbohydrates, phytosterols, saponins, tannins, proteins, flavonoids, and terpenoids. Conclusions: Our findings show that Tinospora cordifolia plays a potential role in combating the antimicrobial resistance of clinical isolates.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=medeniyet&un=MEDJ-84579antimicrobialmicmultidrug resistantplant extracttinospora |
| spellingShingle | Kavitha EZHILARASU Anand KASIRANJAN Shanmuga PRIYA Anand KAMARAJ The Antibacterial Effect of Tinospora Cordifolia (Guduchi) and Its Role in Combating Antimicrobial Resistance Medeniyet Medical Journal antimicrobial mic multidrug resistant plant extract tinospora |
| title | The Antibacterial Effect of Tinospora Cordifolia (Guduchi) and Its Role in Combating Antimicrobial Resistance |
| title_full | The Antibacterial Effect of Tinospora Cordifolia (Guduchi) and Its Role in Combating Antimicrobial Resistance |
| title_fullStr | The Antibacterial Effect of Tinospora Cordifolia (Guduchi) and Its Role in Combating Antimicrobial Resistance |
| title_full_unstemmed | The Antibacterial Effect of Tinospora Cordifolia (Guduchi) and Its Role in Combating Antimicrobial Resistance |
| title_short | The Antibacterial Effect of Tinospora Cordifolia (Guduchi) and Its Role in Combating Antimicrobial Resistance |
| title_sort | antibacterial effect of tinospora cordifolia guduchi and its role in combating antimicrobial resistance |
| topic | antimicrobial mic multidrug resistant plant extract tinospora |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=medeniyet&un=MEDJ-84579 |
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