Differential Cytotoxicity Responses by Dog and Rat Hepatocytes to Phospholipogenic Treatments

Dog and rat hepatocytes were treated with phospholipogenics to identify the more sensitive species and to determine whether lysosomal or mitochondrial changes were the primary cause of cytotoxicity. Endpoints included cell death, lysosome membrane integrity, mitochondrial membrane polarization, and...

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Bibliographic Details
Main Authors: James K. Morelli, Paul J. Ciaccio
Format: Article
Language:English
Published: Wiley 2013-01-01
Series:Journal of Toxicology
Online Access:http://dx.doi.org/10.1155/2013/956404
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