Differential Cytotoxicity Responses by Dog and Rat Hepatocytes to Phospholipogenic Treatments
Dog and rat hepatocytes were treated with phospholipogenics to identify the more sensitive species and to determine whether lysosomal or mitochondrial changes were the primary cause of cytotoxicity. Endpoints included cell death, lysosome membrane integrity, mitochondrial membrane polarization, and...
Saved in:
Main Authors: | James K. Morelli, Paul J. Ciaccio |
---|---|
Format: | Article |
Language: | English |
Published: |
Wiley
2013-01-01
|
Series: | Journal of Toxicology |
Online Access: | http://dx.doi.org/10.1155/2013/956404 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Phospholipogenic Pharmaceuticals Are Associated with a Higher Incidence of Histological Findings than Nonphospholipogenic Pharmaceuticals in Preclinical Toxicology Studies
by: Linda R. Barone, et al.
Published: (2012-01-01) -
Effects of Cytochrome P450 Inhibitors on Itraconazole and Fluconazole Induced Cytotoxicity in Hepatocytes
by: Nhareet Somchit, et al.
Published: (2009-01-01) -
Liver Microbiome in Healthy Rats: The Hidden Inhabitants of Hepatocytes
by: Xiao Wei Sun, et al.
Published: (2023-01-01) -
Differential Impacts of Soybean and Fish Oils on Hepatocyte Lipid Droplet Accumulation and Endoplasmic Reticulum Stress in Primary Rabbit Hepatocytes
by: Xueping Zhu, et al.
Published: (2016-01-01) -
The perspectives of autologous hepatocytes generation for the treatment of liver failure
by: M. N. Evseeva, et al.
Published: (2015-12-01)