Shigella sonnei Bacteremia Presenting with Profound Hepatic Dysfunction
Worldwide, Shigellosis is a significant public health issue, associated with nearly one million deaths annually. About half a million cases of Shigella infection are reported annually in the United States. Shigella bacteremia is uncommon and generally seen in children and immunocompromised adults. W...
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| Format: | Article |
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Wiley
2017-01-01
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| Series: | Case Reports in Gastrointestinal Medicine |
| Online Access: | http://dx.doi.org/10.1155/2017/7293281 |
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| author | Oluwaseun Shogbesan Andrew Rettew Bilal Shaikh Abdullateef Abdulkareem Anthony Donato |
| author_facet | Oluwaseun Shogbesan Andrew Rettew Bilal Shaikh Abdullateef Abdulkareem Anthony Donato |
| author_sort | Oluwaseun Shogbesan |
| collection | DOAJ |
| description | Worldwide, Shigellosis is a significant public health issue, associated with nearly one million deaths annually. About half a million cases of Shigella infection are reported annually in the United States. Shigella bacteremia is uncommon and generally seen in children and immunocompromised adults. We present a case of a Shigella sonnei bacteremia with marked hepatic derangement in a 27-year-old previously healthy homosexual male with history of Roux-en-Y gastric bypass, who presented to the emergency room with a 4-day history of loose watery stool, abdominal cramps, nausea and vomiting, and yellow skin of 2-day duration. He reports similar diarrhea illness in two close contacts in preceding days. On examination, he was fully oriented but dehydrated, icteric, and febrile. Laboratory data revealed WBC of 2200/μL, elevated AST and ALT (201 IU/L, 73 IU/L resp.), normal alkaline phosphatase, elevated total and direct bilirubin of 8.2 mg/dL and 4.4 mg/dL, albumin of 3.2 g/dL, INR of 2.9, prothrombin time of 31.7, and platelet of 96,000/μL. Workup for infectious, autoimmune and medication-induced hepatitis, Wilson’s disease, and hemochromatosis was negative. Abdominal ultrasound and computed tomography of the abdomen showed hepatic steatosis and right-sided colitis. Stool and blood cultures were positive for Shigella sonnei. He was treated with ciprofloxacin with improvement in liver function. Follow-up blood test 4 months later was within normal limits. |
| format | Article |
| id | doaj-art-8d2347f5734a40988cb2e72345c52dcd |
| institution | Kabale University |
| issn | 2090-6528 2090-6536 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Gastrointestinal Medicine |
| spelling | doaj-art-8d2347f5734a40988cb2e72345c52dcd2025-02-03T06:01:01ZengWileyCase Reports in Gastrointestinal Medicine2090-65282090-65362017-01-01201710.1155/2017/72932817293281Shigella sonnei Bacteremia Presenting with Profound Hepatic DysfunctionOluwaseun Shogbesan0Andrew Rettew1Bilal Shaikh2Abdullateef Abdulkareem3Anthony Donato4Department of Internal Medicine, Reading Health System, Spruce Street and 6th Avenue, West Reading, PA 19610, USADepartment of Hematology and Oncology, Banner University Medical Center, Tuscon, AZ, USASt Francis Medical Center, Cape Girardeau, MO, USADepartment of Internal Medicine, Reading Health System, Spruce Street and 6th Avenue, West Reading, PA 19610, USADepartment of Internal Medicine, Reading Health System, Spruce Street and 6th Avenue, West Reading, PA 19610, USAWorldwide, Shigellosis is a significant public health issue, associated with nearly one million deaths annually. About half a million cases of Shigella infection are reported annually in the United States. Shigella bacteremia is uncommon and generally seen in children and immunocompromised adults. We present a case of a Shigella sonnei bacteremia with marked hepatic derangement in a 27-year-old previously healthy homosexual male with history of Roux-en-Y gastric bypass, who presented to the emergency room with a 4-day history of loose watery stool, abdominal cramps, nausea and vomiting, and yellow skin of 2-day duration. He reports similar diarrhea illness in two close contacts in preceding days. On examination, he was fully oriented but dehydrated, icteric, and febrile. Laboratory data revealed WBC of 2200/μL, elevated AST and ALT (201 IU/L, 73 IU/L resp.), normal alkaline phosphatase, elevated total and direct bilirubin of 8.2 mg/dL and 4.4 mg/dL, albumin of 3.2 g/dL, INR of 2.9, prothrombin time of 31.7, and platelet of 96,000/μL. Workup for infectious, autoimmune and medication-induced hepatitis, Wilson’s disease, and hemochromatosis was negative. Abdominal ultrasound and computed tomography of the abdomen showed hepatic steatosis and right-sided colitis. Stool and blood cultures were positive for Shigella sonnei. He was treated with ciprofloxacin with improvement in liver function. Follow-up blood test 4 months later was within normal limits.http://dx.doi.org/10.1155/2017/7293281 |
| spellingShingle | Oluwaseun Shogbesan Andrew Rettew Bilal Shaikh Abdullateef Abdulkareem Anthony Donato Shigella sonnei Bacteremia Presenting with Profound Hepatic Dysfunction Case Reports in Gastrointestinal Medicine |
| title | Shigella sonnei Bacteremia Presenting with Profound Hepatic Dysfunction |
| title_full | Shigella sonnei Bacteremia Presenting with Profound Hepatic Dysfunction |
| title_fullStr | Shigella sonnei Bacteremia Presenting with Profound Hepatic Dysfunction |
| title_full_unstemmed | Shigella sonnei Bacteremia Presenting with Profound Hepatic Dysfunction |
| title_short | Shigella sonnei Bacteremia Presenting with Profound Hepatic Dysfunction |
| title_sort | shigella sonnei bacteremia presenting with profound hepatic dysfunction |
| url | http://dx.doi.org/10.1155/2017/7293281 |
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