Optineurin knock-out forms TDP-43 aggregates to regulate TDP-43 protein levels despite autophagic up-regulation and aberrant TDP-43 expression

Optineurin knock-out forms TDP-43 aggregates to regulate TDP-43 protein levels despite autophagic up-regulation and aberrant TDP-43 expression

Optineurin is a causative gene of amyotrophic lateral sclerosis (ALS) and has many roles in processes such as autophagy and inflammation. However, it is unclear how optineurin causes ALS. Optineurin knock-out (Optn-KO) mice, which have been generated by several researchers, exhibit motor neuron dege...

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Bibliographic Details
Main Authors: Yuta Maetani, Takashi Kurashige, Yui Tada, Kodai Kume, Tomoaki Watanabe, Yusuke Sotomaru, Koji Yamanaka, Hirofumi Maruyama, Hideshi Kawakami
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Neuroscience Research
Subjects:
optineurin
TDP-43
ALS
autophagy
aggregate
Online Access:http://www.sciencedirect.com/science/article/pii/S0168010225000641
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