Effect of Geometry on the Dissolution Behaviour of Complex Additively Manufactured Tablets
Additive manufacturing (AM) processes, such as fused deposition modelling (FDM), have emerged as transformative technologies in pharmaceutical manufacturing, enabling the production of drug delivery systems with complex and customised geometries. These advancements provide precise control over drug...
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MDPI AG
2025-01-01
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| Series: | Journal of Manufacturing and Materials Processing |
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| Online Access: | https://www.mdpi.com/2504-4494/9/1/11 |
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| author | Seyedebrahim Afkhami Meisam Abdi Reza Baserinia |
| author_facet | Seyedebrahim Afkhami Meisam Abdi Reza Baserinia |
| author_sort | Seyedebrahim Afkhami |
| collection | DOAJ |
| description | Additive manufacturing (AM) processes, such as fused deposition modelling (FDM), have emerged as transformative technologies in pharmaceutical manufacturing, enabling the production of drug delivery systems with complex and customised geometries. These advancements provide precise control over drug release profiles and facilitate the development of patient-specific medicines. This study investigates the dissolution behaviour of AM-fabricated tablets made from polyvinyl alcohol (PVA), a hydrophilic and biocompatible polymer widely used in drug delivery systems. The influence of the initial mass, surface area, and surface-area-to-volume ratio (S/V) on dissolution kinetics is evaluated for tablets with intricate geometries. Our findings demonstrate that these parameters, while critical for conventional tablet shapes, are insufficient to fully predict the dissolution behaviour of complex geometries. Furthermore, this study highlights how geometric modifications can enable the administration of the same drug dosage through sustained or immediate release profiles, offering enhanced versatility in drug delivery. By leveraging the geometric design freedom provided by AM technologies, this research underscores the potential for optimising drug delivery systems to improve therapeutic outcomes and patient compliance. |
| format | Article |
| id | doaj-art-8d0ca4bbae4c4b0f95ee9f258fc8ce1f |
| institution | Kabale University |
| issn | 2504-4494 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Manufacturing and Materials Processing |
| spelling | doaj-art-8d0ca4bbae4c4b0f95ee9f258fc8ce1f2025-01-24T13:36:26ZengMDPI AGJournal of Manufacturing and Materials Processing2504-44942025-01-01911110.3390/jmmp9010011Effect of Geometry on the Dissolution Behaviour of Complex Additively Manufactured TabletsSeyedebrahim Afkhami0Meisam Abdi1Reza Baserinia2School of Engineering and Sustainable Development, Faculty of Computing, Engineering, and Media, De Montfort University, Leicester LE1 9BH, UKSchool of Engineering and Sustainable Development, Faculty of Computing, Engineering, and Media, De Montfort University, Leicester LE1 9BH, UKSchool of Engineering, College of Science and Engineering, University of Leicester, Leicester LE1 7RH, UKAdditive manufacturing (AM) processes, such as fused deposition modelling (FDM), have emerged as transformative technologies in pharmaceutical manufacturing, enabling the production of drug delivery systems with complex and customised geometries. These advancements provide precise control over drug release profiles and facilitate the development of patient-specific medicines. This study investigates the dissolution behaviour of AM-fabricated tablets made from polyvinyl alcohol (PVA), a hydrophilic and biocompatible polymer widely used in drug delivery systems. The influence of the initial mass, surface area, and surface-area-to-volume ratio (S/V) on dissolution kinetics is evaluated for tablets with intricate geometries. Our findings demonstrate that these parameters, while critical for conventional tablet shapes, are insufficient to fully predict the dissolution behaviour of complex geometries. Furthermore, this study highlights how geometric modifications can enable the administration of the same drug dosage through sustained or immediate release profiles, offering enhanced versatility in drug delivery. By leveraging the geometric design freedom provided by AM technologies, this research underscores the potential for optimising drug delivery systems to improve therapeutic outcomes and patient compliance.https://www.mdpi.com/2504-4494/9/1/11additive manufacturingtablet dissolutionfused deposition modellingpharmaceutical 3D printing |
| spellingShingle | Seyedebrahim Afkhami Meisam Abdi Reza Baserinia Effect of Geometry on the Dissolution Behaviour of Complex Additively Manufactured Tablets Journal of Manufacturing and Materials Processing additive manufacturing tablet dissolution fused deposition modelling pharmaceutical 3D printing |
| title | Effect of Geometry on the Dissolution Behaviour of Complex Additively Manufactured Tablets |
| title_full | Effect of Geometry on the Dissolution Behaviour of Complex Additively Manufactured Tablets |
| title_fullStr | Effect of Geometry on the Dissolution Behaviour of Complex Additively Manufactured Tablets |
| title_full_unstemmed | Effect of Geometry on the Dissolution Behaviour of Complex Additively Manufactured Tablets |
| title_short | Effect of Geometry on the Dissolution Behaviour of Complex Additively Manufactured Tablets |
| title_sort | effect of geometry on the dissolution behaviour of complex additively manufactured tablets |
| topic | additive manufacturing tablet dissolution fused deposition modelling pharmaceutical 3D printing |
| url | https://www.mdpi.com/2504-4494/9/1/11 |
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