Polymeric immunogel prevents tumor recurrence and metastasis by dual activation of innate and adaptive immunity
Tumor recurrence and metastasis after surgery are important factors affecting patient survival. The immunosuppressed tumor microenvironment after surgery reduces the ability of the immune system to clear residual tumor cells, thus increasing the risk of recurrence and metastasis. Currently, immunoth...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2025-03-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X24004924 |
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| author | Guanyu Jin Hao Liu Zi Mei Qionghua Jin Sheng Ma Lanqing Wang Yuanzhen Su Letian Lv Zijuan Wang Huicong Zhou Mingqiang Li Zehuan Huang Xuesi Chen Shixian Lv |
| author_facet | Guanyu Jin Hao Liu Zi Mei Qionghua Jin Sheng Ma Lanqing Wang Yuanzhen Su Letian Lv Zijuan Wang Huicong Zhou Mingqiang Li Zehuan Huang Xuesi Chen Shixian Lv |
| author_sort | Guanyu Jin |
| collection | DOAJ |
| description | Tumor recurrence and metastasis after surgery are important factors affecting patient survival. The immunosuppressed tumor microenvironment after surgery reduces the ability of the immune system to clear residual tumor cells, thus increasing the risk of recurrence and metastasis. Currently, immunotherapy-based adjuvant therapy can effectively inhibit tumor recurrence and metastasis after surgery, but simultaneous and efficient synergistic activation of adaptive and innate immunity is a challenge. Here, we utilized polymeric hydrogel loaded with decitabine (DAC), cisplatin (CDDP) and manganese ions (Mn2+) as a postoperative filler immunogel to synergistically activate both anti-tumor innate and adaptive immunity. The sustained release of CDDP and DAC burst gasdermin E (GSDME)-mediated pyroptosis and activated adaptive immunity, while Mn2+ enhanced intrinsic immune activation through STING pathway. Such immunogel achieved an encouraging anti-tumor effect with an 80 % total survival rate for recurrent tumors and a 60 % survival rate for metastatic tumors. Considering that this in situ immunogel possesses simple formulation and displays superior anti-tumor effect, this research provided a promising strategy for postoperative cancer therapy. |
| format | Article |
| id | doaj-art-8d02ceedd9fb45a299b1fb2b07541356 |
| institution | Kabale University |
| issn | 2452-199X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj-art-8d02ceedd9fb45a299b1fb2b075413562025-01-26T05:04:20ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2025-03-0145102114Polymeric immunogel prevents tumor recurrence and metastasis by dual activation of innate and adaptive immunityGuanyu Jin0Hao Liu1Zi Mei2Qionghua Jin3Sheng Ma4Lanqing Wang5Yuanzhen Su6Letian Lv7Zijuan Wang8Huicong Zhou9Mingqiang Li10Zehuan Huang11Xuesi Chen12Shixian Lv13School of Materials Science and Engineering and School of Stomatology, Peking University, 100871, Beijing, PR China; Department of Chemistry, Capital Normal University, 100048, Beijing, PR ChinaSchool of Materials Science and Engineering and School of Stomatology, Peking University, 100871, Beijing, PR ChinaSchool of Materials Science and Engineering and School of Stomatology, Peking University, 100871, Beijing, PR ChinaDepartment of Chemistry, Capital Normal University, 100048, Beijing, PR ChinaKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 130022, Changchun, PR ChinaSchool of Materials Science and Engineering and School of Stomatology, Peking University, 100871, Beijing, PR ChinaSchool of Materials Science and Engineering and School of Stomatology, Peking University, 100871, Beijing, PR China; Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 130022, Changchun, PR ChinaSchool of Materials Science and Engineering and School of Stomatology, Peking University, 100871, Beijing, PR ChinaSchool of Materials Science and Engineering and School of Stomatology, Peking University, 100871, Beijing, PR ChinaSchool of Materials Science and Engineering and School of Stomatology, Peking University, 100871, Beijing, PR China; Laboratory of Biomaterials and Translational Medicine, Center for Nanomedicine, The Third Affiliated Hospital, Sun Yat-sen University, 510630, Guangzhou, PR ChinaLaboratory of Biomaterials and Translational Medicine, Center for Nanomedicine, The Third Affiliated Hospital, Sun Yat-sen University, 510630, Guangzhou, PR ChinaSchool of Materials Science and Engineering and School of Stomatology, Peking University, 100871, Beijing, PR ChinaSchool of Materials Science and Engineering and School of Stomatology, Peking University, 100871, Beijing, PR China; Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 130022, Changchun, PR China; Corresponding author. School of Materials Science and Engineering and School of Stomatology, Peking University, 100871, Beijing, PR China.School of Materials Science and Engineering and School of Stomatology, Peking University, 100871, Beijing, PR China; Corresponding author.Tumor recurrence and metastasis after surgery are important factors affecting patient survival. The immunosuppressed tumor microenvironment after surgery reduces the ability of the immune system to clear residual tumor cells, thus increasing the risk of recurrence and metastasis. Currently, immunotherapy-based adjuvant therapy can effectively inhibit tumor recurrence and metastasis after surgery, but simultaneous and efficient synergistic activation of adaptive and innate immunity is a challenge. Here, we utilized polymeric hydrogel loaded with decitabine (DAC), cisplatin (CDDP) and manganese ions (Mn2+) as a postoperative filler immunogel to synergistically activate both anti-tumor innate and adaptive immunity. The sustained release of CDDP and DAC burst gasdermin E (GSDME)-mediated pyroptosis and activated adaptive immunity, while Mn2+ enhanced intrinsic immune activation through STING pathway. Such immunogel achieved an encouraging anti-tumor effect with an 80 % total survival rate for recurrent tumors and a 60 % survival rate for metastatic tumors. Considering that this in situ immunogel possesses simple formulation and displays superior anti-tumor effect, this research provided a promising strategy for postoperative cancer therapy.http://www.sciencedirect.com/science/article/pii/S2452199X24004924Polymeric drug carriersPolymeric hydrogelsBiodegradable polymersControlled drug releaseTumor recurrence and metastasis |
| spellingShingle | Guanyu Jin Hao Liu Zi Mei Qionghua Jin Sheng Ma Lanqing Wang Yuanzhen Su Letian Lv Zijuan Wang Huicong Zhou Mingqiang Li Zehuan Huang Xuesi Chen Shixian Lv Polymeric immunogel prevents tumor recurrence and metastasis by dual activation of innate and adaptive immunity Bioactive Materials Polymeric drug carriers Polymeric hydrogels Biodegradable polymers Controlled drug release Tumor recurrence and metastasis |
| title | Polymeric immunogel prevents tumor recurrence and metastasis by dual activation of innate and adaptive immunity |
| title_full | Polymeric immunogel prevents tumor recurrence and metastasis by dual activation of innate and adaptive immunity |
| title_fullStr | Polymeric immunogel prevents tumor recurrence and metastasis by dual activation of innate and adaptive immunity |
| title_full_unstemmed | Polymeric immunogel prevents tumor recurrence and metastasis by dual activation of innate and adaptive immunity |
| title_short | Polymeric immunogel prevents tumor recurrence and metastasis by dual activation of innate and adaptive immunity |
| title_sort | polymeric immunogel prevents tumor recurrence and metastasis by dual activation of innate and adaptive immunity |
| topic | Polymeric drug carriers Polymeric hydrogels Biodegradable polymers Controlled drug release Tumor recurrence and metastasis |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X24004924 |
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