The Correlation between Chronic Periodontitis and Oral Cancer
Infections are increasingly considered as potential trigger for carcinogenesis apart from risk factors like alcohol and tobacco. The discussion about human papilloma virus (HPV) in oral squamous cell carcinoma (OSCC) points at a general role of infection for the development of oral carcinomas. Furth...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2013/262410 |
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| author | Maximilian Krüger Torsten Hansen Adrian Kasaj Maximilian Moergel |
| author_facet | Maximilian Krüger Torsten Hansen Adrian Kasaj Maximilian Moergel |
| author_sort | Maximilian Krüger |
| collection | DOAJ |
| description | Infections are increasingly considered as potential trigger for carcinogenesis apart from risk factors like alcohol and tobacco. The discussion about human papilloma virus (HPV) in oral squamous cell carcinoma (OSCC) points at a general role of infection for the development of oral carcinomas. Furthermore, first studies describe a correlation between chronic periodontitis and OSCC, thus, characterizing chronic inflammation as being a possible trigger for OSCC. In front of this background, we present four well-documented clinical cases. All patients showed a significant anatomical relation between OSCC and clinical signs of chronic periodontitis. The interindividual differences of the clinical findings lead to different theoretical concepts: two with coincidental appearance of OSCC and chronic periodontitis and two with possible de novo development of OSCC triggered by chronic inflammation. We conclude that the activation of different inflammatory cascades by chronic periodontitis negatively affects mucosa and bone. Furthermore, the inflammatory response has the potential to activate carcinogenesis. Apart from a mere coincidental occurrence, two out of four patients give first clinical hints for a model wherein chronic periodontitis represents a potential risk factor for the development of OSCC. |
| format | Article |
| id | doaj-art-8ce25067bb574375a2bbe9459a35611a |
| institution | Kabale University |
| issn | 2090-6447 2090-6455 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Dentistry |
| spelling | doaj-art-8ce25067bb574375a2bbe9459a35611a2025-02-03T01:01:41ZengWileyCase Reports in Dentistry2090-64472090-64552013-01-01201310.1155/2013/262410262410The Correlation between Chronic Periodontitis and Oral CancerMaximilian Krüger0Torsten Hansen1Adrian Kasaj2Maximilian Moergel3Department of Oral and Maxillofacial Surgery-Plastic Surgery, Johannes Gutenberg University of Mainz, Medical Center, Augustusplatz 2, 55131 Mainz, GermanyInstitute of Pathology, University of Mainz, Medical Surgery, Langenbeckstraße 1, 55131 Mainz, GermanyDepartment of Operative Dentistry and Periodontology, Johannes Gutenberg-University, Augustusplatz 2, 55131 Mainz, GermanyDepartment of Oral and Maxillofacial Surgery-Plastic Surgery, Johannes Gutenberg University of Mainz, Medical Center, Augustusplatz 2, 55131 Mainz, GermanyInfections are increasingly considered as potential trigger for carcinogenesis apart from risk factors like alcohol and tobacco. The discussion about human papilloma virus (HPV) in oral squamous cell carcinoma (OSCC) points at a general role of infection for the development of oral carcinomas. Furthermore, first studies describe a correlation between chronic periodontitis and OSCC, thus, characterizing chronic inflammation as being a possible trigger for OSCC. In front of this background, we present four well-documented clinical cases. All patients showed a significant anatomical relation between OSCC and clinical signs of chronic periodontitis. The interindividual differences of the clinical findings lead to different theoretical concepts: two with coincidental appearance of OSCC and chronic periodontitis and two with possible de novo development of OSCC triggered by chronic inflammation. We conclude that the activation of different inflammatory cascades by chronic periodontitis negatively affects mucosa and bone. Furthermore, the inflammatory response has the potential to activate carcinogenesis. Apart from a mere coincidental occurrence, two out of four patients give first clinical hints for a model wherein chronic periodontitis represents a potential risk factor for the development of OSCC.http://dx.doi.org/10.1155/2013/262410 |
| spellingShingle | Maximilian Krüger Torsten Hansen Adrian Kasaj Maximilian Moergel The Correlation between Chronic Periodontitis and Oral Cancer Case Reports in Dentistry |
| title | The Correlation between Chronic Periodontitis and Oral Cancer |
| title_full | The Correlation between Chronic Periodontitis and Oral Cancer |
| title_fullStr | The Correlation between Chronic Periodontitis and Oral Cancer |
| title_full_unstemmed | The Correlation between Chronic Periodontitis and Oral Cancer |
| title_short | The Correlation between Chronic Periodontitis and Oral Cancer |
| title_sort | correlation between chronic periodontitis and oral cancer |
| url | http://dx.doi.org/10.1155/2013/262410 |
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