Effects of Silybum marianum Extract on High-Fat Diet Induced Metabolic Disorders in Rats
Silybum marianum extract (SME) has been used for centuries as a natural remedy for diseases of liver and biliary tract. Lately, it has been promoted as a nutritional supplement for beneficial effects on some risk factors of diabetes and hyperlipidemia. In this study we aimed to determine the effects...
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Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences
2016-03-01
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| Series: | Polish Journal of Food and Nutrition Sciences |
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| Online Access: | http://www.degruyter.com/view/j/pjfns.2016.66.issue-1/pjfns-2015-0014/pjfns-2015-0014.xml?format=INT |
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| author | Sayin Fatma Kubra Buyukbas Sadik Basarali M. Kemal Alp Harun Toy Hatice Ugurcu Veli |
| author_facet | Sayin Fatma Kubra Buyukbas Sadik Basarali M. Kemal Alp Harun Toy Hatice Ugurcu Veli |
| author_sort | Sayin Fatma Kubra |
| collection | DOAJ |
| description | Silybum marianum extract (SME) has been used for centuries as a natural remedy for diseases of liver and biliary tract. Lately, it has been promoted as a nutritional supplement for beneficial effects on some risk factors of diabetes and hyperlipidemia. In this study we aimed to determine the effects of SME on high-fat diet (HFD) induced metabolic disorders. Male Sprague Dawley rats were fed HFD for 11 weeks to induce obesity. SME was given to animals for two different durations, for 11 weeks or for 7 weeks. The results showed significant increase in plasma transaminases, total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C), leptin, high sensitive C-reactive protein (hsCRP), glucose and insulin along with significant increase in body mass index (BMI) and liver weights in rats fed the HFD diet compared to rats fed with standard rat diet. SME supplementation for different durations raised improvement in the HFD-induced metabolic disorders such as insulin resistance, hyperlipidemia and hepatopathy at different degrees. Our study concludes that SME can be well considered as an effective supplement to improve insulin and leptin sensitivity and hyperlipidemia and to suppress body weight gain. |
| format | Article |
| id | doaj-art-8ce02ca327b547a08e2931cefdfba2ef |
| institution | Kabale University |
| issn | 2083-6007 |
| language | English |
| publishDate | 2016-03-01 |
| publisher | Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences |
| record_format | Article |
| series | Polish Journal of Food and Nutrition Sciences |
| spelling | doaj-art-8ce02ca327b547a08e2931cefdfba2ef2025-02-02T15:35:48ZengInstitute of Animal Reproduction and Food Research of the Polish Academy of SciencesPolish Journal of Food and Nutrition Sciences2083-60072016-03-01661435010.1515/pjfns-2015-0014pjfns-2015-0014Effects of Silybum marianum Extract on High-Fat Diet Induced Metabolic Disorders in RatsSayin Fatma Kubra0Buyukbas Sadik1Basarali M. Kemal2Alp Harun3Toy Hatice4Ugurcu Veli5Department of Nutrition and Dietetics, Health Sciences Faculty, Necmettin Erbakan University, Konya, TurkeyDepartment of Biochemistry, Meram Medical Faculty, Konya Necmettin Erbakan University, Konya, TurkeyDepartment of Biochemistry, Medical Faculty, Dicle University, Diyarbakır, TurkeyDepartment of Pharmacology and Toxicology, Medical Faculty, Mustafa Kemal University, Hatay, TurkeyDepartment of Pathology, Meram Medical Faculty, Konya Necmettin Erbakan University, Konya, TurkeyPrivate Bilecik Orhangazi Dialysis Center, Bilecik, TurkeySilybum marianum extract (SME) has been used for centuries as a natural remedy for diseases of liver and biliary tract. Lately, it has been promoted as a nutritional supplement for beneficial effects on some risk factors of diabetes and hyperlipidemia. In this study we aimed to determine the effects of SME on high-fat diet (HFD) induced metabolic disorders. Male Sprague Dawley rats were fed HFD for 11 weeks to induce obesity. SME was given to animals for two different durations, for 11 weeks or for 7 weeks. The results showed significant increase in plasma transaminases, total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C), leptin, high sensitive C-reactive protein (hsCRP), glucose and insulin along with significant increase in body mass index (BMI) and liver weights in rats fed the HFD diet compared to rats fed with standard rat diet. SME supplementation for different durations raised improvement in the HFD-induced metabolic disorders such as insulin resistance, hyperlipidemia and hepatopathy at different degrees. Our study concludes that SME can be well considered as an effective supplement to improve insulin and leptin sensitivity and hyperlipidemia and to suppress body weight gain.http://www.degruyter.com/view/j/pjfns.2016.66.issue-1/pjfns-2015-0014/pjfns-2015-0014.xml?format=INTSilybum marianumcholesterolinsulinleptinhigh-fat diet |
| spellingShingle | Sayin Fatma Kubra Buyukbas Sadik Basarali M. Kemal Alp Harun Toy Hatice Ugurcu Veli Effects of Silybum marianum Extract on High-Fat Diet Induced Metabolic Disorders in Rats Polish Journal of Food and Nutrition Sciences Silybum marianum cholesterol insulin leptin high-fat diet |
| title | Effects of Silybum marianum Extract on High-Fat Diet Induced Metabolic Disorders in Rats |
| title_full | Effects of Silybum marianum Extract on High-Fat Diet Induced Metabolic Disorders in Rats |
| title_fullStr | Effects of Silybum marianum Extract on High-Fat Diet Induced Metabolic Disorders in Rats |
| title_full_unstemmed | Effects of Silybum marianum Extract on High-Fat Diet Induced Metabolic Disorders in Rats |
| title_short | Effects of Silybum marianum Extract on High-Fat Diet Induced Metabolic Disorders in Rats |
| title_sort | effects of silybum marianum extract on high fat diet induced metabolic disorders in rats |
| topic | Silybum marianum cholesterol insulin leptin high-fat diet |
| url | http://www.degruyter.com/view/j/pjfns.2016.66.issue-1/pjfns-2015-0014/pjfns-2015-0014.xml?format=INT |
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