Morphologic and hemodynamic analysis of intracranial mirror aneurysms
Intracranial mirror aneurysms are pathologic dilatations of cerebral arteries that occur at identical locations in both hemispheres. They do not always have identical sizes, shapes, or rupture states, despite identical patient-specific risk factors. As a subgroup of multiple aneurysms and thus small...
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| Format: | Article |
| Language: | English |
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De Gruyter
2024-09-01
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| Series: | Current Directions in Biomedical Engineering |
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| Online Access: | https://doi.org/10.1515/cdbme-2024-1074 |
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| author | Spitz L. Schmidt J. Korte J. Berg P. Behme D. Neyazi B. Preim B. Saalfeld S. |
| author_facet | Spitz L. Schmidt J. Korte J. Berg P. Behme D. Neyazi B. Preim B. Saalfeld S. |
| author_sort | Spitz L. |
| collection | DOAJ |
| description | Intracranial mirror aneurysms are pathologic dilatations of cerebral arteries that occur at identical locations in both hemispheres. They do not always have identical sizes, shapes, or rupture states, despite identical patient-specific risk factors. As a subgroup of multiple aneurysms and thus small amounts of data, clinical research about their causes and development has not been conclusive. Using eight patients with 16 mirror aneurysms with different rupture states, we investigated differences between the hemispheres. We virtually performed stitching: detaching the aneurysm domes to place them on the opposite parent vessel to assess the influence of aneurysm morphology and upstream parent vessel shape on hemodynamics. In the unaltered datasets, we found that blood flow within aneurysms in the left hemisphere has higher wall shear stress and velocity. After stitching, we found that both upstream parent vessel as well as aneurysm morphology influence hemodynamics. Morphologic parameters like size, undulation index, and aneurysm angle had a higher influence. In a short rupture risk analysis we found a correlation between rupture and aspect ratio and non-sphericity index. Overall, we found possible indicators for mirror aneurysm analysis that illustrated the importance of morphological analysis, though more datasets are necessary for conclusive statements about special treatment for mirror aneurysms. |
| format | Article |
| id | doaj-art-8cdcaf9eb2a94921852460efe4370074 |
| institution | Kabale University |
| issn | 2364-5504 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Current Directions in Biomedical Engineering |
| spelling | doaj-art-8cdcaf9eb2a94921852460efe43700742025-02-02T15:45:00ZengDe GruyterCurrent Directions in Biomedical Engineering2364-55042024-09-01102879010.1515/cdbme-2024-1074Morphologic and hemodynamic analysis of intracranial mirror aneurysmsSpitz L.0Schmidt J.1Korte J.2Berg P.3Behme D.4Neyazi B.5Preim B.6Saalfeld S.7Department of Simulation and Graphics, Otto-von-Guericke University,Magdeburg, GermanyDepartment of Simulation and Graphics, Otto-von-Guericke University,Magdeburg, GermanyForschungscampus STIMULATE,Magdeburg, GermanyForschungscampus STIMULATE,Magdeburg, GermanyForschungscampus STIMULATE,Magdeburg, GermanyUniversity Clinic for Neurosurgery, OvGUMagdeburg, GermanyDepartment of Simulation and Graphics, Otto-von-Guericke University,Magdeburg, GermanyForschungscampus STIMULATE,Magdeburg, GermanyIntracranial mirror aneurysms are pathologic dilatations of cerebral arteries that occur at identical locations in both hemispheres. They do not always have identical sizes, shapes, or rupture states, despite identical patient-specific risk factors. As a subgroup of multiple aneurysms and thus small amounts of data, clinical research about their causes and development has not been conclusive. Using eight patients with 16 mirror aneurysms with different rupture states, we investigated differences between the hemispheres. We virtually performed stitching: detaching the aneurysm domes to place them on the opposite parent vessel to assess the influence of aneurysm morphology and upstream parent vessel shape on hemodynamics. In the unaltered datasets, we found that blood flow within aneurysms in the left hemisphere has higher wall shear stress and velocity. After stitching, we found that both upstream parent vessel as well as aneurysm morphology influence hemodynamics. Morphologic parameters like size, undulation index, and aneurysm angle had a higher influence. In a short rupture risk analysis we found a correlation between rupture and aspect ratio and non-sphericity index. Overall, we found possible indicators for mirror aneurysm analysis that illustrated the importance of morphological analysis, though more datasets are necessary for conclusive statements about special treatment for mirror aneurysms.https://doi.org/10.1515/cdbme-2024-1074intracranial aneurysmsmirror aneurysmsmorphological analysishemodynamic analysis. |
| spellingShingle | Spitz L. Schmidt J. Korte J. Berg P. Behme D. Neyazi B. Preim B. Saalfeld S. Morphologic and hemodynamic analysis of intracranial mirror aneurysms Current Directions in Biomedical Engineering intracranial aneurysms mirror aneurysms morphological analysis hemodynamic analysis. |
| title | Morphologic and hemodynamic analysis of intracranial mirror aneurysms |
| title_full | Morphologic and hemodynamic analysis of intracranial mirror aneurysms |
| title_fullStr | Morphologic and hemodynamic analysis of intracranial mirror aneurysms |
| title_full_unstemmed | Morphologic and hemodynamic analysis of intracranial mirror aneurysms |
| title_short | Morphologic and hemodynamic analysis of intracranial mirror aneurysms |
| title_sort | morphologic and hemodynamic analysis of intracranial mirror aneurysms |
| topic | intracranial aneurysms mirror aneurysms morphological analysis hemodynamic analysis. |
| url | https://doi.org/10.1515/cdbme-2024-1074 |
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