Crystal Structures of Tcl1 Family Oncoproteins and Their Conserved Surface Features
Members of the TCL1 family of oncogenes are abnormally expressed in mature T-cell leukemias and B-cell lymphomas. The proteins are involved in the coactivation of protein kinase B (Akt/PKB), a key intracellular kinase. The sequences and crystal structures of three Tcl1 proteins were analyzed in orde...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2002-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2002.826 |
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| author | John M. Petock Ivan Y. Torshin Yuan-Fang Wang Garrett C. Du Bois Carlo M. Croce Robert W. Harrison Irene T. Weber |
| author_facet | John M. Petock Ivan Y. Torshin Yuan-Fang Wang Garrett C. Du Bois Carlo M. Croce Robert W. Harrison Irene T. Weber |
| author_sort | John M. Petock |
| collection | DOAJ |
| description | Members of the TCL1 family of oncogenes are abnormally expressed in mature T-cell leukemias and B-cell lymphomas. The proteins are involved in the coactivation of protein kinase B (Akt/PKB), a key intracellular kinase. The sequences and crystal structures of three Tcl1 proteins were analyzed in order to understand their interactions with Akt/PKB and the implications for lymphocyte malignancies. Tcl1 proteins are ~15 kD and share 25—80% amino acid sequence identity. The tertiary structures of mouse Tcl1, human Tcl1, and Mtcp1 are very similar. Analysis of the structures revealed conserved semi-planar surfaces that have characteristics of surfaces involved in protein-protein interactions. The Tcl1 proteins show differences in surface charge distribution and oligomeric state suggesting that they do not interact in the same way with Akt/PKB and other cellular protein(s). |
| format | Article |
| id | doaj-art-8cd51e397ddc4b6b8782adc26b34fcb9 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2002-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-8cd51e397ddc4b6b8782adc26b34fcb92025-02-03T06:00:08ZengWileyThe Scientific World Journal1537-744X2002-01-0121876188410.1100/tsw.2002.826Crystal Structures of Tcl1 Family Oncoproteins and Their Conserved Surface FeaturesJohn M. Petock0Ivan Y. Torshin1Yuan-Fang Wang2Garrett C. Du Bois3Carlo M. Croce4Robert W. Harrison5Irene T. Weber6Department of Biology, Georgia State University, Atlanta, GA, USADepartment of Biology, Georgia State University, Atlanta, GA, USADepartment of Biology, Georgia State University, Atlanta, GA, USADepartment of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USADepartment of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USADepartment of Computer Science, Georgia State University, Atlanta, GA, USADepartment of Biology, Georgia State University, Atlanta, GA, USAMembers of the TCL1 family of oncogenes are abnormally expressed in mature T-cell leukemias and B-cell lymphomas. The proteins are involved in the coactivation of protein kinase B (Akt/PKB), a key intracellular kinase. The sequences and crystal structures of three Tcl1 proteins were analyzed in order to understand their interactions with Akt/PKB and the implications for lymphocyte malignancies. Tcl1 proteins are ~15 kD and share 25—80% amino acid sequence identity. The tertiary structures of mouse Tcl1, human Tcl1, and Mtcp1 are very similar. Analysis of the structures revealed conserved semi-planar surfaces that have characteristics of surfaces involved in protein-protein interactions. The Tcl1 proteins show differences in surface charge distribution and oligomeric state suggesting that they do not interact in the same way with Akt/PKB and other cellular protein(s).http://dx.doi.org/10.1100/tsw.2002.826 |
| spellingShingle | John M. Petock Ivan Y. Torshin Yuan-Fang Wang Garrett C. Du Bois Carlo M. Croce Robert W. Harrison Irene T. Weber Crystal Structures of Tcl1 Family Oncoproteins and Their Conserved Surface Features The Scientific World Journal |
| title | Crystal Structures of Tcl1 Family Oncoproteins and Their Conserved Surface Features |
| title_full | Crystal Structures of Tcl1 Family Oncoproteins and Their Conserved Surface Features |
| title_fullStr | Crystal Structures of Tcl1 Family Oncoproteins and Their Conserved Surface Features |
| title_full_unstemmed | Crystal Structures of Tcl1 Family Oncoproteins and Their Conserved Surface Features |
| title_short | Crystal Structures of Tcl1 Family Oncoproteins and Their Conserved Surface Features |
| title_sort | crystal structures of tcl1 family oncoproteins and their conserved surface features |
| url | http://dx.doi.org/10.1100/tsw.2002.826 |
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