Mechanisms and environmental factors shaping the ecosystem of brain macrophages

Mechanisms and environmental factors shaping the ecosystem of brain macrophages

Brain macrophages encompass two major populations: microglia in the parenchyma and border-associated macrophages (BAMs) in the extra-parenchymal compartments. These cells play crucial roles in maintaining brain homeostasis and immune surveillance. Microglia and BAMs are phenotypically and epigenetic...

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Bibliographic Details
Main Authors: Silvia Penati, Simone Brioschi, Zhangying Cai, Claudia Z. Han, Marco Colonna
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
brain macrophages
microglia
border-associated-macrophages
ontogeny
yolk sac
brain development
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1539988/full
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