Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome Following Initiation of Sulfasalazine for Ulcerative Colitis: A Yearlong Clinical Challenge
Sulfasalazine, a commonly prescribed medication for treating ulcerative colitis, can cause a severe yet rare adverse drug reaction known as drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. In this case, a female patient experienced a severe flare of her ulcerative colitis, acc...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
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| Series: | Case Reports in Gastrointestinal Medicine |
| Online Access: | http://dx.doi.org/10.1155/crgm/8870613 |
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| Summary: | Sulfasalazine, a commonly prescribed medication for treating ulcerative colitis, can cause a severe yet rare adverse drug reaction known as drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. In this case, a female patient experienced a severe flare of her ulcerative colitis, accompanied by sulfasalazine-induced DRESS syndrome. The ulcerative colitis flare and acute liver injury resolved with a treatment regimen of high-dose steroids and cyclosporine. However, she continued to have treatment-resistant dermatologic changes and delayed organ involvement, including the development of hyperthyroidism that required close multidisciplinary follow-up. IVIG was used to successfully wean steroids and cyclosporine after a year of therapy. |
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| ISSN: | 2090-6536 |