Primary Vaginal Myeloid Sarcoma: A Rare Case Report and Review of the Literature
Myeloid sarcoma (chloroma, granulocytic sarcoma, or extramedullary myeloid tumour) is an extramedullary mass forming neoplasm composed of myeloid precursor cells. It is usually associated with myeloproliferative disorders but very rarely may precede the onset of leukemia. Here, we are presenting a r...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Obstetrics and Gynecology |
| Online Access: | http://dx.doi.org/10.1155/2015/957490 |
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| author | Gaurang Modi Irappa Madabhavi Harsha Panchal Apurva Patel Asha Anand Sonia Parikh Pritam Jain Swaroop Revannasiddaiah Malay Sarkar |
| author_facet | Gaurang Modi Irappa Madabhavi Harsha Panchal Apurva Patel Asha Anand Sonia Parikh Pritam Jain Swaroop Revannasiddaiah Malay Sarkar |
| author_sort | Gaurang Modi |
| collection | DOAJ |
| description | Myeloid sarcoma (chloroma, granulocytic sarcoma, or extramedullary myeloid tumour) is an extramedullary mass forming neoplasm composed of myeloid precursor cells. It is usually associated with myeloproliferative disorders but very rarely may precede the onset of leukemia. Here, we are presenting a rare case of primary vaginal myeloid sarcoma in a geriatric female patient without initial presentation of acute myeloid leukemia (AML). A 68-year-old female patient with ECOG Performance Score of 1 presented with pervaginal bleeding for 20 days. On colposcopic examination, she was found to have mass in the anterior fornix of vagina. A punch biopsy specimen revealed chloromatous infiltration of the vagina. LCA (leukocyte common antigen), MPO (myeloperoxidase), and c-kit were strongly positive on IHC (immunohistochemistry). The patient’s routine blood investigations were normal including peripheral smear, lactose dehydrogenase, uric acid, 2D echocardiography, conventional cytogenetics, bone marrow aspiration, and biopsy. The patient was given 4 cycles of decitabine (Decitex, manufactured by Sun Pharmaceutical Industries Limited, India), 20 mg/m2 for 5 days at an interval of 28 days. There was a partial response to decitabine according to RECIST criteria. As decitabine therapy was well tolerated, we are continuing in the same way until disease progression without any complications. The patient is undergoing regular follow-up at our centre. |
| format | Article |
| id | doaj-art-8cc0f85344cd40529eb3cc81ade768a1 |
| institution | Kabale University |
| issn | 2090-6684 2090-6692 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Obstetrics and Gynecology |
| spelling | doaj-art-8cc0f85344cd40529eb3cc81ade768a12025-02-03T01:13:12ZengWileyCase Reports in Obstetrics and Gynecology2090-66842090-66922015-01-01201510.1155/2015/957490957490Primary Vaginal Myeloid Sarcoma: A Rare Case Report and Review of the LiteratureGaurang Modi0Irappa Madabhavi1Harsha Panchal2Apurva Patel3Asha Anand4Sonia Parikh5Pritam Jain6Swaroop Revannasiddaiah7Malay Sarkar8Department of Medical and Paediatric Oncology, GCRI, Ahmedabad, Gujarat, IndiaDepartment of Medical and Paediatric Oncology, GCRI, Ahmedabad, Gujarat, IndiaDepartment of Medical and Paediatric Oncology, GCRI, Ahmedabad, Gujarat, IndiaDepartment of Medical and Paediatric Oncology, GCRI, Ahmedabad, Gujarat, IndiaDepartment of Medical and Paediatric Oncology, GCRI, Ahmedabad, Gujarat, IndiaDepartment of Medical and Paediatric Oncology, GCRI, Ahmedabad, Gujarat, IndiaDepartment of Medical and Paediatric Oncology, GCRI, Ahmedabad, Gujarat, IndiaDepartment of Radiotherapy, Government Medical College, Haldwani, IndiaDepartment of Pulmonary Medicine, IGMC, Shimla, Himachal Pradesh, IndiaMyeloid sarcoma (chloroma, granulocytic sarcoma, or extramedullary myeloid tumour) is an extramedullary mass forming neoplasm composed of myeloid precursor cells. It is usually associated with myeloproliferative disorders but very rarely may precede the onset of leukemia. Here, we are presenting a rare case of primary vaginal myeloid sarcoma in a geriatric female patient without initial presentation of acute myeloid leukemia (AML). A 68-year-old female patient with ECOG Performance Score of 1 presented with pervaginal bleeding for 20 days. On colposcopic examination, she was found to have mass in the anterior fornix of vagina. A punch biopsy specimen revealed chloromatous infiltration of the vagina. LCA (leukocyte common antigen), MPO (myeloperoxidase), and c-kit were strongly positive on IHC (immunohistochemistry). The patient’s routine blood investigations were normal including peripheral smear, lactose dehydrogenase, uric acid, 2D echocardiography, conventional cytogenetics, bone marrow aspiration, and biopsy. The patient was given 4 cycles of decitabine (Decitex, manufactured by Sun Pharmaceutical Industries Limited, India), 20 mg/m2 for 5 days at an interval of 28 days. There was a partial response to decitabine according to RECIST criteria. As decitabine therapy was well tolerated, we are continuing in the same way until disease progression without any complications. The patient is undergoing regular follow-up at our centre.http://dx.doi.org/10.1155/2015/957490 |
| spellingShingle | Gaurang Modi Irappa Madabhavi Harsha Panchal Apurva Patel Asha Anand Sonia Parikh Pritam Jain Swaroop Revannasiddaiah Malay Sarkar Primary Vaginal Myeloid Sarcoma: A Rare Case Report and Review of the Literature Case Reports in Obstetrics and Gynecology |
| title | Primary Vaginal Myeloid Sarcoma: A Rare Case Report and Review of the Literature |
| title_full | Primary Vaginal Myeloid Sarcoma: A Rare Case Report and Review of the Literature |
| title_fullStr | Primary Vaginal Myeloid Sarcoma: A Rare Case Report and Review of the Literature |
| title_full_unstemmed | Primary Vaginal Myeloid Sarcoma: A Rare Case Report and Review of the Literature |
| title_short | Primary Vaginal Myeloid Sarcoma: A Rare Case Report and Review of the Literature |
| title_sort | primary vaginal myeloid sarcoma a rare case report and review of the literature |
| url | http://dx.doi.org/10.1155/2015/957490 |
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