Association between Serum Uric Acid Level and Metabolic Syndrome and Its Sex Difference in a Chinese Community Elderly Population
Objective. This study aimed to evaluate the association between serum uric acid (SUA) levels within a normal to high range and the risk of metabolic syndrome (MetS) among community elderly and explore the sex difference. Design and Methods. A cross-sectional study was conducted in a representative u...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2014/754678 |
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| _version_ | 1832548688582410240 |
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| author | Miao Liu Yao He Bin Jiang Lei Wu Shanshan Yang Yiyan Wang Xiaoying Li |
| author_facet | Miao Liu Yao He Bin Jiang Lei Wu Shanshan Yang Yiyan Wang Xiaoying Li |
| author_sort | Miao Liu |
| collection | DOAJ |
| description | Objective. This study aimed to evaluate the association between serum uric acid (SUA) levels within a normal to high range and the risk of metabolic syndrome (MetS) among community elderly and explore the sex difference. Design and Methods. A cross-sectional study was conducted in a representative urban area of Beijing between 2009 and 2010. A two-stage stratified clustering sampling method was used and 2102 elderly participants were included. Results. The prevalence of hyperuricemia and MetS was 16.7% and 59.1%, respectively. There was a strong association between hyperuricemia and four components of MetS in women and three components in men. Multiple logistic regression analysis showed ORs of hyperuricemia for MetS were 1.67 (95% CI: 1.11–2.50) in men and 2.73 (95% CI: 1.81–4.11) in women. Even in the normal range, the ORs for MetS increased gradually according to SUA levels. MetS component number also showed an increasing trend across SUA quartile in both sexes (P for trend < 0.01). Conclusion. This study suggests that higher SUA levels, even in the normal range, are positively associated with MetS among Chinese community elderly, and the association is stronger in women than men. Physicians should recognize MetS as a frequent comorbidity of hyperuricemia and take early action to prevent subsequent disease burden. |
| format | Article |
| id | doaj-art-8cbfdf82389843f78149f7ef51c6b0cd |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-8cbfdf82389843f78149f7ef51c6b0cd2025-02-03T06:13:25ZengWileyInternational Journal of Endocrinology1687-83371687-83452014-01-01201410.1155/2014/754678754678Association between Serum Uric Acid Level and Metabolic Syndrome and Its Sex Difference in a Chinese Community Elderly PopulationMiao Liu0Yao He1Bin Jiang2Lei Wu3Shanshan Yang4Yiyan Wang5Xiaoying Li6Institute of Geriatrics, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, ChinaInstitute of Geriatrics, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, ChinaDepartment of Chinese Traditional Medicine and Acupuncture, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, ChinaInstitute of Geriatrics, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, ChinaInstitute of Geriatrics, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, ChinaInstitute of Geriatrics, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, ChinaDepartment of Geriatric Cardiology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, ChinaObjective. This study aimed to evaluate the association between serum uric acid (SUA) levels within a normal to high range and the risk of metabolic syndrome (MetS) among community elderly and explore the sex difference. Design and Methods. A cross-sectional study was conducted in a representative urban area of Beijing between 2009 and 2010. A two-stage stratified clustering sampling method was used and 2102 elderly participants were included. Results. The prevalence of hyperuricemia and MetS was 16.7% and 59.1%, respectively. There was a strong association between hyperuricemia and four components of MetS in women and three components in men. Multiple logistic regression analysis showed ORs of hyperuricemia for MetS were 1.67 (95% CI: 1.11–2.50) in men and 2.73 (95% CI: 1.81–4.11) in women. Even in the normal range, the ORs for MetS increased gradually according to SUA levels. MetS component number also showed an increasing trend across SUA quartile in both sexes (P for trend < 0.01). Conclusion. This study suggests that higher SUA levels, even in the normal range, are positively associated with MetS among Chinese community elderly, and the association is stronger in women than men. Physicians should recognize MetS as a frequent comorbidity of hyperuricemia and take early action to prevent subsequent disease burden.http://dx.doi.org/10.1155/2014/754678 |
| spellingShingle | Miao Liu Yao He Bin Jiang Lei Wu Shanshan Yang Yiyan Wang Xiaoying Li Association between Serum Uric Acid Level and Metabolic Syndrome and Its Sex Difference in a Chinese Community Elderly Population International Journal of Endocrinology |
| title | Association between Serum Uric Acid Level and Metabolic Syndrome and Its Sex Difference in a Chinese Community Elderly Population |
| title_full | Association between Serum Uric Acid Level and Metabolic Syndrome and Its Sex Difference in a Chinese Community Elderly Population |
| title_fullStr | Association between Serum Uric Acid Level and Metabolic Syndrome and Its Sex Difference in a Chinese Community Elderly Population |
| title_full_unstemmed | Association between Serum Uric Acid Level and Metabolic Syndrome and Its Sex Difference in a Chinese Community Elderly Population |
| title_short | Association between Serum Uric Acid Level and Metabolic Syndrome and Its Sex Difference in a Chinese Community Elderly Population |
| title_sort | association between serum uric acid level and metabolic syndrome and its sex difference in a chinese community elderly population |
| url | http://dx.doi.org/10.1155/2014/754678 |
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