Long term impacts of early social environment on chimpanzee white matter
Abstract Early adverse rearing conditions are known to have deleterious consequences on social behavior, cognition, and brain development of both human and nonhuman primates. We analyzed archival diffusion tensor imaging (DTI) data from mother- (MR) or nursery-reared (NR) chimpanzees and used suppor...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-12-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-024-81238-9 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850136549491998720 |
|---|---|
| author | Michele M. Mulholland Erin Hecht Michael J. Wesley William D. Hopkins |
| author_facet | Michele M. Mulholland Erin Hecht Michael J. Wesley William D. Hopkins |
| author_sort | Michele M. Mulholland |
| collection | DOAJ |
| description | Abstract Early adverse rearing conditions are known to have deleterious consequences on social behavior, cognition, and brain development of both human and nonhuman primates. We analyzed archival diffusion tensor imaging (DTI) data from mother- (MR) or nursery-reared (NR) chimpanzees and used support vector machine learning to determine whether we could retrospectively classify chimpanzees as MR or NR based on white matter fractional anisotropy (FA) decades after their rearing experiences. A significant proportion of chimpanzees were correctly classified as MR and NR based on white matter fractional anisotropy (76.32%; p = 0.004). Voxel-based morphometry revealed that MR chimpanzees had increased FA in the splenium/isthmus of the corpus collosum and premotor cortex, while NR chimpanzees had increased FA in the thalamic region, cuneus, and lateral genu of the corpus collosum (p < 0.01). A subset of the NR chimpanzees participated in early social interventions, but unlike gray matter, these interventions do not explain misclassification based on white matter. These findings suggest that nursery rearing has long-term effects on both gray and white matter, but that early interventions may ameliorate the effects on gray matter only. Future research should investigate the effectiveness and relative contributions of combined social, cognitive, and nutritional interventions on brain development in nonhuman primates. |
| format | Article |
| id | doaj-art-8cb1b6622e88481ebf75a12c6c14c7d2 |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-8cb1b6622e88481ebf75a12c6c14c7d22025-08-20T02:31:04ZengNature PortfolioScientific Reports2045-23222024-12-011411810.1038/s41598-024-81238-9Long term impacts of early social environment on chimpanzee white matterMichele M. Mulholland0Erin Hecht1Michael J. Wesley2William D. Hopkins3Department of Comparative Medicine, Michale E Keeling Center for Comparative Medicine and Research, The University of Texas MD Anderson Cancer CenterDepartment of Human Evolutionary Biology, Harvard UniversityDepartment of Behavioral Science, University of Kentucky College of MedicineDepartment of Comparative Medicine, Michale E Keeling Center for Comparative Medicine and Research, The University of Texas MD Anderson Cancer CenterAbstract Early adverse rearing conditions are known to have deleterious consequences on social behavior, cognition, and brain development of both human and nonhuman primates. We analyzed archival diffusion tensor imaging (DTI) data from mother- (MR) or nursery-reared (NR) chimpanzees and used support vector machine learning to determine whether we could retrospectively classify chimpanzees as MR or NR based on white matter fractional anisotropy (FA) decades after their rearing experiences. A significant proportion of chimpanzees were correctly classified as MR and NR based on white matter fractional anisotropy (76.32%; p = 0.004). Voxel-based morphometry revealed that MR chimpanzees had increased FA in the splenium/isthmus of the corpus collosum and premotor cortex, while NR chimpanzees had increased FA in the thalamic region, cuneus, and lateral genu of the corpus collosum (p < 0.01). A subset of the NR chimpanzees participated in early social interventions, but unlike gray matter, these interventions do not explain misclassification based on white matter. These findings suggest that nursery rearing has long-term effects on both gray and white matter, but that early interventions may ameliorate the effects on gray matter only. Future research should investigate the effectiveness and relative contributions of combined social, cognitive, and nutritional interventions on brain development in nonhuman primates.https://doi.org/10.1038/s41598-024-81238-9Adverse rearingBrain developmentWhite matterChimpanzeesMachine learning |
| spellingShingle | Michele M. Mulholland Erin Hecht Michael J. Wesley William D. Hopkins Long term impacts of early social environment on chimpanzee white matter Scientific Reports Adverse rearing Brain development White matter Chimpanzees Machine learning |
| title | Long term impacts of early social environment on chimpanzee white matter |
| title_full | Long term impacts of early social environment on chimpanzee white matter |
| title_fullStr | Long term impacts of early social environment on chimpanzee white matter |
| title_full_unstemmed | Long term impacts of early social environment on chimpanzee white matter |
| title_short | Long term impacts of early social environment on chimpanzee white matter |
| title_sort | long term impacts of early social environment on chimpanzee white matter |
| topic | Adverse rearing Brain development White matter Chimpanzees Machine learning |
| url | https://doi.org/10.1038/s41598-024-81238-9 |
| work_keys_str_mv | AT michelemmulholland longtermimpactsofearlysocialenvironmentonchimpanzeewhitematter AT erinhecht longtermimpactsofearlysocialenvironmentonchimpanzeewhitematter AT michaeljwesley longtermimpactsofearlysocialenvironmentonchimpanzeewhitematter AT williamdhopkins longtermimpactsofearlysocialenvironmentonchimpanzeewhitematter |