Noise-Induced Hearing Loss: Updates on Molecular Targets and Potential Interventions
Noise overexposure leads to hair cell loss, synaptic ribbon reduction, and auditory nerve deterioration, resulting in transient or permanent hearing loss depending on the exposure severity. Oxidative stress, inflammation, calcium overload, glutamate excitotoxicity, and energy metabolism disturbance...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2021/4784385 |
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| _version_ | 1832567659708809216 |
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| author | Huanyu Mao Yan Chen |
| author_facet | Huanyu Mao Yan Chen |
| author_sort | Huanyu Mao |
| collection | DOAJ |
| description | Noise overexposure leads to hair cell loss, synaptic ribbon reduction, and auditory nerve deterioration, resulting in transient or permanent hearing loss depending on the exposure severity. Oxidative stress, inflammation, calcium overload, glutamate excitotoxicity, and energy metabolism disturbance are the main contributors to noise-induced hearing loss (NIHL) up to now. Gene variations are also identified as NIHL related. Glucocorticoid is the only approved medication for NIHL treatment. New pharmaceuticals targeting oxidative stress, inflammation, or noise-induced neuropathy are emerging, highlighted by the nanoparticle-based drug delivery system. Given the complexity of the pathogenesis behind NIHL, deeper and more comprehensive studies still need to be fulfilled. |
| format | Article |
| id | doaj-art-8cb1057bd207402f9116e5cd65cd9776 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-8cb1057bd207402f9116e5cd65cd97762025-02-03T01:00:48ZengWileyNeural Plasticity2090-59041687-54432021-01-01202110.1155/2021/47843854784385Noise-Induced Hearing Loss: Updates on Molecular Targets and Potential InterventionsHuanyu Mao0Yan Chen1ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai 200031, ChinaENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai 200031, ChinaNoise overexposure leads to hair cell loss, synaptic ribbon reduction, and auditory nerve deterioration, resulting in transient or permanent hearing loss depending on the exposure severity. Oxidative stress, inflammation, calcium overload, glutamate excitotoxicity, and energy metabolism disturbance are the main contributors to noise-induced hearing loss (NIHL) up to now. Gene variations are also identified as NIHL related. Glucocorticoid is the only approved medication for NIHL treatment. New pharmaceuticals targeting oxidative stress, inflammation, or noise-induced neuropathy are emerging, highlighted by the nanoparticle-based drug delivery system. Given the complexity of the pathogenesis behind NIHL, deeper and more comprehensive studies still need to be fulfilled.http://dx.doi.org/10.1155/2021/4784385 |
| spellingShingle | Huanyu Mao Yan Chen Noise-Induced Hearing Loss: Updates on Molecular Targets and Potential Interventions Neural Plasticity |
| title | Noise-Induced Hearing Loss: Updates on Molecular Targets and Potential Interventions |
| title_full | Noise-Induced Hearing Loss: Updates on Molecular Targets and Potential Interventions |
| title_fullStr | Noise-Induced Hearing Loss: Updates on Molecular Targets and Potential Interventions |
| title_full_unstemmed | Noise-Induced Hearing Loss: Updates on Molecular Targets and Potential Interventions |
| title_short | Noise-Induced Hearing Loss: Updates on Molecular Targets and Potential Interventions |
| title_sort | noise induced hearing loss updates on molecular targets and potential interventions |
| url | http://dx.doi.org/10.1155/2021/4784385 |
| work_keys_str_mv | AT huanyumao noiseinducedhearinglossupdatesonmoleculartargetsandpotentialinterventions AT yanchen noiseinducedhearinglossupdatesonmoleculartargetsandpotentialinterventions |