New-to-nature CO2-dependent acetyl-CoA assimilation enabled by an engineered B12-dependent acyl-CoA mutase

New-to-nature CO2-dependent acetyl-CoA assimilation enabled by an engineered B12-dependent acyl-CoA mutase

Abstract Acetyl-CoA is a key metabolic intermediate and the product of various natural and synthetic one-carbon (C1) assimilation pathways. While an efficient conversion of acetyl-CoA into other central metabolites, such as pyruvate, is imperative for high biomass yields, available aerobic pathways...

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Bibliographic Details
Main Authors: Helena Schulz-Mirbach, Philipp Wichmann, Ari Satanowski, Helen Meusel, Tong Wu, Maren Nattermann, Simon Burgener, Nicole Paczia, Arren Bar-Even, Tobias J. Erb
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-53762-9
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