Computational phenotyping of two-person interactions reveals differential neural response to depth-of-thought.
Reciprocating exchange with other humans requires individuals to infer the intentions of their partners. Despite the importance of this ability in healthy cognition and its impact in disease, the dimensions employed and computations involved in such inferences are not clear. We used a computational...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS Computational Biology |
| Online Access: | https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002841&type=printable |
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| author | Ting Xiang Debajyoti Ray Terry Lohrenz Peter Dayan P Read Montague |
| author_facet | Ting Xiang Debajyoti Ray Terry Lohrenz Peter Dayan P Read Montague |
| author_sort | Ting Xiang |
| collection | DOAJ |
| description | Reciprocating exchange with other humans requires individuals to infer the intentions of their partners. Despite the importance of this ability in healthy cognition and its impact in disease, the dimensions employed and computations involved in such inferences are not clear. We used a computational theory-of-mind model to classify styles of interaction in 195 pairs of subjects playing a multi-round economic exchange game. This classification produces an estimate of a subject's depth-of-thought in the game (low, medium, high), a parameter that governs the richness of the models they build of their partner. Subjects in each category showed distinct neural correlates of learning signals associated with different depths-of-thought. The model also detected differences in depth-of-thought between two groups of healthy subjects: one playing patients with psychiatric disease and the other playing healthy controls. The neural response categories identified by this computational characterization of theory-of-mind may yield objective biomarkers useful in the identification and characterization of pathologies that perturb the capacity to model and interact with other humans. |
| format | Article |
| id | doaj-art-8cadb5a059df4be5b34f86d5e52dbd01 |
| institution | OA Journals |
| issn | 1553-734X 1553-7358 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Computational Biology |
| spelling | doaj-art-8cadb5a059df4be5b34f86d5e52dbd012025-08-20T02:34:09ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582012-01-01812e100284110.1371/journal.pcbi.1002841Computational phenotyping of two-person interactions reveals differential neural response to depth-of-thought.Ting XiangDebajyoti RayTerry LohrenzPeter DayanP Read MontagueReciprocating exchange with other humans requires individuals to infer the intentions of their partners. Despite the importance of this ability in healthy cognition and its impact in disease, the dimensions employed and computations involved in such inferences are not clear. We used a computational theory-of-mind model to classify styles of interaction in 195 pairs of subjects playing a multi-round economic exchange game. This classification produces an estimate of a subject's depth-of-thought in the game (low, medium, high), a parameter that governs the richness of the models they build of their partner. Subjects in each category showed distinct neural correlates of learning signals associated with different depths-of-thought. The model also detected differences in depth-of-thought between two groups of healthy subjects: one playing patients with psychiatric disease and the other playing healthy controls. The neural response categories identified by this computational characterization of theory-of-mind may yield objective biomarkers useful in the identification and characterization of pathologies that perturb the capacity to model and interact with other humans.https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002841&type=printable |
| spellingShingle | Ting Xiang Debajyoti Ray Terry Lohrenz Peter Dayan P Read Montague Computational phenotyping of two-person interactions reveals differential neural response to depth-of-thought. PLoS Computational Biology |
| title | Computational phenotyping of two-person interactions reveals differential neural response to depth-of-thought. |
| title_full | Computational phenotyping of two-person interactions reveals differential neural response to depth-of-thought. |
| title_fullStr | Computational phenotyping of two-person interactions reveals differential neural response to depth-of-thought. |
| title_full_unstemmed | Computational phenotyping of two-person interactions reveals differential neural response to depth-of-thought. |
| title_short | Computational phenotyping of two-person interactions reveals differential neural response to depth-of-thought. |
| title_sort | computational phenotyping of two person interactions reveals differential neural response to depth of thought |
| url | https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002841&type=printable |
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