Interactions of the CSF3R polymorphism and early stress on future orientation: evidence for the differential model of stress-related growth
Abstract Aims This study aims to explore the concept of future orientation, which encompasses individuals’ thoughts about the future, goal-setting, planning, response to challenges and behavioural adjustments in evolving situations. Often viewed as a psychological resource, future orientation is bel...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2024-01-01
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| Series: | Epidemiology and Psychiatric Sciences |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S2045796024000581/type/journal_article |
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| author | Yiqun Gan Lizhong Wang Yidi Chen Lei Zheng Xiaoli Wu Gang Chen Yueqin Hu |
| author_facet | Yiqun Gan Lizhong Wang Yidi Chen Lei Zheng Xiaoli Wu Gang Chen Yueqin Hu |
| author_sort | Yiqun Gan |
| collection | DOAJ |
| description | Abstract
Aims
This study aims to explore the concept of future orientation, which encompasses individuals’ thoughts about the future, goal-setting, planning, response to challenges and behavioural adjustments in evolving situations. Often viewed as a psychological resource, future orientation is believed to be developed from psychological resilience. The study investigates the curvilinear relationship between childhood maltreatment and future orientation while examining the moderating effects of genotype.
Methods
A total of 14,675 Chinese adults self-reported their experiences of childhood maltreatment and their future orientation. The influence of genetic polymorphism was evaluated through genome-wide interaction studies (GWIS; genome-wide association study [GWAS] using gene × environment interaction) and a candidate genes approach.
Results
Both GWAS and candidate genes analyses consistently indicated that rs4498771 and its linked single-nucleotide polymorphisms, located in the intergenic area surrounding CSF3R, significantly interacted with early trauma to influence future orientation. Nonlinear regression analyses identified a quadratic or cubic association between future orientation and childhood maltreatment across some genotypes. Specifically, as levels of childhood maltreatment increased, future orientation declined for all genotypes. However, upon reaching a certain threshold, future orientation exhibited a rebound in individuals with specific genotypes.
Conclusions
The findings suggest that individuals with certain genotypes exhibit greater resilience to childhood maltreatment. Based on these results, we propose a new threshold model of stress-related growth.
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| format | Article |
| id | doaj-art-8caa8c2d23b742aabeddecd1a27076b1 |
| institution | OA Journals |
| issn | 2045-7960 2045-7979 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Epidemiology and Psychiatric Sciences |
| spelling | doaj-art-8caa8c2d23b742aabeddecd1a27076b12025-08-20T02:01:45ZengCambridge University PressEpidemiology and Psychiatric Sciences2045-79602045-79792024-01-013310.1017/S2045796024000581Interactions of the CSF3R polymorphism and early stress on future orientation: evidence for the differential model of stress-related growthYiqun Gan0https://orcid.org/0000-0001-9886-6862Lizhong Wang1Yidi Chen2Lei Zheng3Xiaoli Wu4Gang Chen5Yueqin Hu6School of Psychological and Cognitive Sciences and Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing, ChinaHunan Provincial Key Lab on Bioinformatics, School of Computer Science and Engineering, Central South University, Changsha, P. R. China WeGene, Shenzhen Zaozhidao Technology Co. Ltd., TianAn CyberTech Plaza I, Shenzhen, P. R. ChinaSchool of Psychological and Cognitive Sciences and Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing, ChinaSchool of Economics and Management, Fuzhou University, Fuzhou, ChinaWeGene, Shenzhen Zaozhidao Technology Co. Ltd., TianAn CyberTech Plaza I, Shenzhen, P. R. ChinaHunan Provincial Key Lab on Bioinformatics, School of Computer Science and Engineering, Central South University, Changsha, P. R. China WeGene, Shenzhen Zaozhidao Technology Co. Ltd., TianAn CyberTech Plaza I, Shenzhen, P. R. China Shenzhen WeGene Clinical Laboratory, Haikexing Industrial Park, Shenzhen, P. R. ChinaSchool of Psychology, Beijing Normal University, Beijing, ChinaAbstract Aims This study aims to explore the concept of future orientation, which encompasses individuals’ thoughts about the future, goal-setting, planning, response to challenges and behavioural adjustments in evolving situations. Often viewed as a psychological resource, future orientation is believed to be developed from psychological resilience. The study investigates the curvilinear relationship between childhood maltreatment and future orientation while examining the moderating effects of genotype. Methods A total of 14,675 Chinese adults self-reported their experiences of childhood maltreatment and their future orientation. The influence of genetic polymorphism was evaluated through genome-wide interaction studies (GWIS; genome-wide association study [GWAS] using gene × environment interaction) and a candidate genes approach. Results Both GWAS and candidate genes analyses consistently indicated that rs4498771 and its linked single-nucleotide polymorphisms, located in the intergenic area surrounding CSF3R, significantly interacted with early trauma to influence future orientation. Nonlinear regression analyses identified a quadratic or cubic association between future orientation and childhood maltreatment across some genotypes. Specifically, as levels of childhood maltreatment increased, future orientation declined for all genotypes. However, upon reaching a certain threshold, future orientation exhibited a rebound in individuals with specific genotypes. Conclusions The findings suggest that individuals with certain genotypes exhibit greater resilience to childhood maltreatment. Based on these results, we propose a new threshold model of stress-related growth. https://www.cambridge.org/core/product/identifier/S2045796024000581/type/journal_articleCSF3Rfuture orientationgene × environment interactiongenome-wide interaction studiesthreshold model of stress-related growth |
| spellingShingle | Yiqun Gan Lizhong Wang Yidi Chen Lei Zheng Xiaoli Wu Gang Chen Yueqin Hu Interactions of the CSF3R polymorphism and early stress on future orientation: evidence for the differential model of stress-related growth Epidemiology and Psychiatric Sciences CSF3R future orientation gene × environment interaction genome-wide interaction studies threshold model of stress-related growth |
| title | Interactions of the CSF3R polymorphism and early stress on future orientation: evidence for the differential model of stress-related growth |
| title_full | Interactions of the CSF3R polymorphism and early stress on future orientation: evidence for the differential model of stress-related growth |
| title_fullStr | Interactions of the CSF3R polymorphism and early stress on future orientation: evidence for the differential model of stress-related growth |
| title_full_unstemmed | Interactions of the CSF3R polymorphism and early stress on future orientation: evidence for the differential model of stress-related growth |
| title_short | Interactions of the CSF3R polymorphism and early stress on future orientation: evidence for the differential model of stress-related growth |
| title_sort | interactions of the csf3r polymorphism and early stress on future orientation evidence for the differential model of stress related growth |
| topic | CSF3R future orientation gene × environment interaction genome-wide interaction studies threshold model of stress-related growth |
| url | https://www.cambridge.org/core/product/identifier/S2045796024000581/type/journal_article |
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