Biomarkers of Periodontal Tissue Remodeling during Orthodontic Tooth Movement in Mice and Men: Overview and Clinical Relevance
Biologically active substances are expressed by cells within the periodontium in response to mechanical stimuli from orthodontic appliances. Several possible biomarkers representing biological modifications during specific phenomena as simile-inflammatory process, bone resorption and formation, peri...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/105873 |
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| author | Fabrizia d'Apuzzo Salvatore Cappabianca Domenico Ciavarella Angela Monsurrò Armando Silvestrini-Biavati Letizia Perillo |
| author_facet | Fabrizia d'Apuzzo Salvatore Cappabianca Domenico Ciavarella Angela Monsurrò Armando Silvestrini-Biavati Letizia Perillo |
| author_sort | Fabrizia d'Apuzzo |
| collection | DOAJ |
| description | Biologically active substances are expressed by cells within the periodontium in response to mechanical stimuli from orthodontic appliances. Several possible biomarkers representing biological modifications during specific phenomena as simile-inflammatory process, bone resorption and formation, periodontal ligament changes, and vascular and neural responses are proposed. Citations to potentially published trials were conducted by searching PubMed, Cochrane databases, and scientific textbooks. Additionally, hand searching and contact with experts in the area were undertaken to identify potentially relevant published and unpublished studies. Selection criteria were as follows: animal models involving only mice and rats undergoing orthodontic treatment; collection of gingival crevicular fluid (GCF) as a noninvasively procedure for humans; no other simultaneous treatment that could affect experimental orthodontic movement. The data suggest that knowledge of the remodeling process occurring in periodontal tissues during orthodontic and orthopedic therapies may be a clinical usefulness procedure leading to proper choice of mechanical stress to improve and to shorten the period of treatment, avoiding adverse consequences. The relevance for clinicians of evaluating the rate of some substances as valid biomarkers of periodontal effects during orthodontic movement, by means of two models of study, mice and men, is underlined. |
| format | Article |
| id | doaj-art-8ca65decb3054430aa220561399606c2 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-8ca65decb3054430aa220561399606c22025-02-03T01:00:51ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/105873105873Biomarkers of Periodontal Tissue Remodeling during Orthodontic Tooth Movement in Mice and Men: Overview and Clinical RelevanceFabrizia d'Apuzzo0Salvatore Cappabianca1Domenico Ciavarella2Angela Monsurrò3Armando Silvestrini-Biavati4Letizia Perillo5Department of Orthodontics, Second University of Naples, Via L. De Crecchio 6, 80138 Naples, ItalyDepartment of Radiology, Second University of Naples, Piazza L. Miraglia 5, 80138 Naples, ItalyDepartment of Clinical and Experimental Medicine, University of Foggia, Viale L. Pinto, 71100 Foggia, ItalyDepartment of Orthodontics, Second University of Naples, Via L. De Crecchio 6, 80138 Naples, ItalyDepartment of Orthodontics, University of Genoa, Corso Europa 35, 16132 Genoa, ItalyDepartment of Orthodontics, Second University of Naples, Via L. De Crecchio 6, 80138 Naples, ItalyBiologically active substances are expressed by cells within the periodontium in response to mechanical stimuli from orthodontic appliances. Several possible biomarkers representing biological modifications during specific phenomena as simile-inflammatory process, bone resorption and formation, periodontal ligament changes, and vascular and neural responses are proposed. Citations to potentially published trials were conducted by searching PubMed, Cochrane databases, and scientific textbooks. Additionally, hand searching and contact with experts in the area were undertaken to identify potentially relevant published and unpublished studies. Selection criteria were as follows: animal models involving only mice and rats undergoing orthodontic treatment; collection of gingival crevicular fluid (GCF) as a noninvasively procedure for humans; no other simultaneous treatment that could affect experimental orthodontic movement. The data suggest that knowledge of the remodeling process occurring in periodontal tissues during orthodontic and orthopedic therapies may be a clinical usefulness procedure leading to proper choice of mechanical stress to improve and to shorten the period of treatment, avoiding adverse consequences. The relevance for clinicians of evaluating the rate of some substances as valid biomarkers of periodontal effects during orthodontic movement, by means of two models of study, mice and men, is underlined.http://dx.doi.org/10.1155/2013/105873 |
| spellingShingle | Fabrizia d'Apuzzo Salvatore Cappabianca Domenico Ciavarella Angela Monsurrò Armando Silvestrini-Biavati Letizia Perillo Biomarkers of Periodontal Tissue Remodeling during Orthodontic Tooth Movement in Mice and Men: Overview and Clinical Relevance The Scientific World Journal |
| title | Biomarkers of Periodontal Tissue Remodeling during Orthodontic Tooth Movement in Mice and Men: Overview and Clinical Relevance |
| title_full | Biomarkers of Periodontal Tissue Remodeling during Orthodontic Tooth Movement in Mice and Men: Overview and Clinical Relevance |
| title_fullStr | Biomarkers of Periodontal Tissue Remodeling during Orthodontic Tooth Movement in Mice and Men: Overview and Clinical Relevance |
| title_full_unstemmed | Biomarkers of Periodontal Tissue Remodeling during Orthodontic Tooth Movement in Mice and Men: Overview and Clinical Relevance |
| title_short | Biomarkers of Periodontal Tissue Remodeling during Orthodontic Tooth Movement in Mice and Men: Overview and Clinical Relevance |
| title_sort | biomarkers of periodontal tissue remodeling during orthodontic tooth movement in mice and men overview and clinical relevance |
| url | http://dx.doi.org/10.1155/2013/105873 |
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