Viridans Streptococcal Biofilm Evades Immune Detection and Contributes to Inflammation and Rupture of Atherosclerotic Plaques

Viridans Streptococcal Biofilm Evades Immune Detection and Contributes to Inflammation and Rupture of Atherosclerotic Plaques

Background Bacterial DNA from the oral cavity, respiratory tract, gut, and skin has been detected in atherosclerotic plaques, suggesting a role in chronic inflammation linked to atherosclerosis. Chronic bacterial infections often form biofilms resistant to antibiotics and immune detection, giving ri...

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Main Authors: Pekka J. Karhunen, Tanja Pessi, Sohvi Hörkkö, Vesa Karhunen, Sirkka Goebeler, Anne‐Mari Louhelainen, Mika Martiskainen, Teppo Haapaniemi, Johanna Lappeteläinen, Tommi Ijäs, Leo‐Pekka Lyytikäinen, Emma Raitoharju, Thanos Sioris, Sari Tuomisto, Heini Huhtala, Chunguang Wang, Claudia Monaco, Niku Oksala, Terho Lehtimäki, Reijo Laaksonen
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
bacteria
biofilm
coronary heart disease
immune system
myocardial infarction
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.125.041521
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