Analgesic and Antioxidant Activities of 4-Phenyl-1,5-benzodiazepin-2-one and Its Long Carbon Chains Derivatives
The aim of this work is to deepen the pharmacological effect of 4-phenyl-1,5-benzodiazepin-2-one derivatives which have a similar structure to nonionic surfactants: 4-phenyl-1,5-benzodiazepin-2-one is the hydrophilic head, and the carbon chain is hydrophobic tail. The antinociceptive activity of 4-p...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2019/9043570 |
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| author | Terence Nguema Ongone Redouane Achour Mostafa El Ghoul Latyfa El Ouasif Meryem El Jemli Laila Chemlal Yahia Cherrah Katim Alaoui Amina Zellou |
| author_facet | Terence Nguema Ongone Redouane Achour Mostafa El Ghoul Latyfa El Ouasif Meryem El Jemli Laila Chemlal Yahia Cherrah Katim Alaoui Amina Zellou |
| author_sort | Terence Nguema Ongone |
| collection | DOAJ |
| description | The aim of this work is to deepen the pharmacological effect of 4-phenyl-1,5-benzodiazepin-2-one derivatives which have a similar structure to nonionic surfactants: 4-phenyl-1,5-benzodiazepin-2-one is the hydrophilic head, and the carbon chain is hydrophobic tail. The antinociceptive activity of 4-phenyl-1,5-benzodiazepin-2-one derivatives was determined using acetic acid-induced writhing and tail immersion tests. In addition, the in vitro antioxidant activities of the tested derivatives were determined by using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging method and ferric reducing power assay. A single oral administration of these compounds at the doses of 50 and 100 mg/kg significantly reduced the number of abdominal writhes induced by acetic acid injection. Acute pretreatment with 4-phenyl-1,5-benzodiazepin-2-one derivatives at the dose of 100 mg/kg caused a significant increase in the tail withdrawal latency in the tail immersion test. Additionally, a significant scavenging activity in DPPH and reducing power was observed in testing antioxidant assays. Finally, we carried out a study of the antioxidant activity of these derivatives. The results of this study reveal that these compounds have a low antioxidant activity compared to the BHT. It decreases with the polarity of the molecule. The present study suggests that 4-phenyl-1,5-benzodiazepin-2-one derivatives possess potent antinociceptive and antioxidant effects, which suggest that the tested compounds may be useful in the treatment of pain and oxidation disorders. |
| format | Article |
| id | doaj-art-8c9f027bc8fb4d13b954bdc29d8c0217 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-8c9f027bc8fb4d13b954bdc29d8c02172025-02-03T05:53:55ZengWileyJournal of Chemistry2090-90632090-90712019-01-01201910.1155/2019/90435709043570Analgesic and Antioxidant Activities of 4-Phenyl-1,5-benzodiazepin-2-one and Its Long Carbon Chains DerivativesTerence Nguema Ongone0Redouane Achour1Mostafa El Ghoul2Latyfa El Ouasif3Meryem El Jemli4Laila Chemlal5Yahia Cherrah6Katim Alaoui7Amina Zellou8Laboratory of Heterocyclic Organic Chemistry, Drug Sciences Research Center, URAC 21, Pole of Competence Pharmacochemistry, Faculty of Sciences, Mohammed V University in Rabat, Avenue Ibn Battouta, BP 1014 Rabat, MoroccoLaboratory of Heterocyclic Organic Chemistry, Drug Sciences Research Center, URAC 21, Pole of Competence Pharmacochemistry, Faculty of Sciences, Mohammed V University in Rabat, Avenue Ibn Battouta, BP 1014 Rabat, MoroccoLaboratory of Heterocyclic Organic Chemistry, Drug Sciences Research Center, URAC 21, Pole of Competence Pharmacochemistry, Faculty of Sciences, Mohammed V University in Rabat, Avenue Ibn Battouta, BP 1014 Rabat, MoroccoLaboratory of Heterocyclic Organic Chemistry, Drug Sciences Research Center, URAC 21, Pole of Competence Pharmacochemistry, Faculty of Sciences, Mohammed V University in Rabat, Avenue Ibn Battouta, BP 1014 Rabat, MoroccoPharmacodynamy Research Team PRT, Laboratory of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, BP 6203 Rabat, MoroccoPharmacodynamy Research Team PRT, Laboratory of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, BP 6203 Rabat, MoroccoPharmacodynamy Research Team PRT, Laboratory of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, BP 6203 Rabat, MoroccoPharmacodynamy Research Team PRT, Laboratory of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, BP 6203 Rabat, MoroccoPharmacodynamy Research Team PRT, Laboratory of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, BP 6203 Rabat, MoroccoThe aim of this work is to deepen the pharmacological effect of 4-phenyl-1,5-benzodiazepin-2-one derivatives which have a similar structure to nonionic surfactants: 4-phenyl-1,5-benzodiazepin-2-one is the hydrophilic head, and the carbon chain is hydrophobic tail. The antinociceptive activity of 4-phenyl-1,5-benzodiazepin-2-one derivatives was determined using acetic acid-induced writhing and tail immersion tests. In addition, the in vitro antioxidant activities of the tested derivatives were determined by using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging method and ferric reducing power assay. A single oral administration of these compounds at the doses of 50 and 100 mg/kg significantly reduced the number of abdominal writhes induced by acetic acid injection. Acute pretreatment with 4-phenyl-1,5-benzodiazepin-2-one derivatives at the dose of 100 mg/kg caused a significant increase in the tail withdrawal latency in the tail immersion test. Additionally, a significant scavenging activity in DPPH and reducing power was observed in testing antioxidant assays. Finally, we carried out a study of the antioxidant activity of these derivatives. The results of this study reveal that these compounds have a low antioxidant activity compared to the BHT. It decreases with the polarity of the molecule. The present study suggests that 4-phenyl-1,5-benzodiazepin-2-one derivatives possess potent antinociceptive and antioxidant effects, which suggest that the tested compounds may be useful in the treatment of pain and oxidation disorders.http://dx.doi.org/10.1155/2019/9043570 |
| spellingShingle | Terence Nguema Ongone Redouane Achour Mostafa El Ghoul Latyfa El Ouasif Meryem El Jemli Laila Chemlal Yahia Cherrah Katim Alaoui Amina Zellou Analgesic and Antioxidant Activities of 4-Phenyl-1,5-benzodiazepin-2-one and Its Long Carbon Chains Derivatives Journal of Chemistry |
| title | Analgesic and Antioxidant Activities of 4-Phenyl-1,5-benzodiazepin-2-one and Its Long Carbon Chains Derivatives |
| title_full | Analgesic and Antioxidant Activities of 4-Phenyl-1,5-benzodiazepin-2-one and Its Long Carbon Chains Derivatives |
| title_fullStr | Analgesic and Antioxidant Activities of 4-Phenyl-1,5-benzodiazepin-2-one and Its Long Carbon Chains Derivatives |
| title_full_unstemmed | Analgesic and Antioxidant Activities of 4-Phenyl-1,5-benzodiazepin-2-one and Its Long Carbon Chains Derivatives |
| title_short | Analgesic and Antioxidant Activities of 4-Phenyl-1,5-benzodiazepin-2-one and Its Long Carbon Chains Derivatives |
| title_sort | analgesic and antioxidant activities of 4 phenyl 1 5 benzodiazepin 2 one and its long carbon chains derivatives |
| url | http://dx.doi.org/10.1155/2019/9043570 |
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