Corneal Deposit of Ciprofloxacin after Laser Assisted Subepithelial Keratomileusis Procedure: A Case Report
Purpose. To report one case of corneal antibiotic deposition after ciprofloxacin administration in Laser Assisted Subepithelial Keratomileusis (LASEK). Methods. One case of post-LASEK treatment resulted in corneal precipitates and poor wound healing. Debris was analyzed with dark field microscopy a...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2010/296034 |
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| _version_ | 1832561029485166592 |
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| author | Giacomo De Benedetti Andrea Brancaccio |
| author_facet | Giacomo De Benedetti Andrea Brancaccio |
| author_sort | Giacomo De Benedetti |
| collection | DOAJ |
| description | Purpose. To report one case of corneal antibiotic deposition after ciprofloxacin administration in Laser Assisted Subepithelial Keratomileusis (LASEK). Methods. One case of post-LASEK treatment resulted in corneal precipitates and poor wound healing. Debris was analyzed with dark field microscopy and placed on a blood-agar plate seeded with a susceptible stain of Staphylococcus aureus (ATCC 29213). Results. The alterations resolved with discontinuation of ciprofloxacin treatment, although some residual deposits persisted subepithelially for 6 months. Analysis of precipitates revealed polydisperse crystalline needles of 183 𝜇m average length (SD=54 𝜇m) and the excised precipitate demonstrated a zone of inhibition. Conclusions. Fluoroquinolone antibiotic drops have been used extensively in postsurgical treatment of refractive surgery. Corneal precipitates have been previously reported in the literature, but up to now nothing has been documented after LASEK. Polypharmacy during refractive surgery may impair epithelialisation, and clinical management should reduce toxic environment and promote ocular surface stability when performing surface ablations. |
| format | Article |
| id | doaj-art-8c9edfff3e874e3aaf8d28c8b512c56a |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-8c9edfff3e874e3aaf8d28c8b512c56a2025-02-03T01:26:11ZengWileyJournal of Ophthalmology2090-004X2090-00582010-01-01201010.1155/2010/296034296034Corneal Deposit of Ciprofloxacin after Laser Assisted Subepithelial Keratomileusis Procedure: A Case ReportGiacomo De Benedetti0Andrea Brancaccio1Hospital Quirón Donostia, 7, Parque Alcolea, 20012 San Sebastian, SpainIstituto di Chimica del Riconoscimento Molecolare (CNR) c/o Istituto di Biochimica e Biochimica Clinica, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168 Roma, ItalyPurpose. To report one case of corneal antibiotic deposition after ciprofloxacin administration in Laser Assisted Subepithelial Keratomileusis (LASEK). Methods. One case of post-LASEK treatment resulted in corneal precipitates and poor wound healing. Debris was analyzed with dark field microscopy and placed on a blood-agar plate seeded with a susceptible stain of Staphylococcus aureus (ATCC 29213). Results. The alterations resolved with discontinuation of ciprofloxacin treatment, although some residual deposits persisted subepithelially for 6 months. Analysis of precipitates revealed polydisperse crystalline needles of 183 𝜇m average length (SD=54 𝜇m) and the excised precipitate demonstrated a zone of inhibition. Conclusions. Fluoroquinolone antibiotic drops have been used extensively in postsurgical treatment of refractive surgery. Corneal precipitates have been previously reported in the literature, but up to now nothing has been documented after LASEK. Polypharmacy during refractive surgery may impair epithelialisation, and clinical management should reduce toxic environment and promote ocular surface stability when performing surface ablations.http://dx.doi.org/10.1155/2010/296034 |
| spellingShingle | Giacomo De Benedetti Andrea Brancaccio Corneal Deposit of Ciprofloxacin after Laser Assisted Subepithelial Keratomileusis Procedure: A Case Report Journal of Ophthalmology |
| title | Corneal Deposit of Ciprofloxacin after Laser Assisted Subepithelial Keratomileusis Procedure: A Case Report |
| title_full | Corneal Deposit of Ciprofloxacin after Laser Assisted Subepithelial Keratomileusis Procedure: A Case Report |
| title_fullStr | Corneal Deposit of Ciprofloxacin after Laser Assisted Subepithelial Keratomileusis Procedure: A Case Report |
| title_full_unstemmed | Corneal Deposit of Ciprofloxacin after Laser Assisted Subepithelial Keratomileusis Procedure: A Case Report |
| title_short | Corneal Deposit of Ciprofloxacin after Laser Assisted Subepithelial Keratomileusis Procedure: A Case Report |
| title_sort | corneal deposit of ciprofloxacin after laser assisted subepithelial keratomileusis procedure a case report |
| url | http://dx.doi.org/10.1155/2010/296034 |
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