The RNA pseudoknots in foot-and-mouth disease virus are dispensable for genome replication, but essential for the production of infectious virus.

The RNA pseudoknots in foot-and-mouth disease virus are dispensable for genome replication, but essential for the production of infectious virus.

Non-coding regions of viral RNA (vRNA) genomes are critically important in the regulation of gene expression. In particular, pseudoknot (PK) structures, which are present in a wide range of RNA molecules, have a variety of roles. The 5' untranslated region (5' UTR) of foot-and-mouth diseas...

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Main Authors: Joseph C Ward, Lidia Lasecka-Dykes, Chris Neil, Oluwapelumi O Adeyemi, Sarah Gold, Niall McLean-Pell, Caroline Wright, Morgan R Herod, David Kealy, Emma Warner, Terry Jackson, Donald P King, Tobias J Tuthill, David J Rowlands, Nicola J Stonehouse
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-06-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1010589&type=printable
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