Process analytical technology tools for process control of roller compaction in solid pharmaceuticals manufacturing
This article presents an overview of using process analytical technology in monitoring the roller compaction process. In the past two decades, near-infrared spectroscopy, near-infrared spectroscopy coupled with chemical imaging, microwave resonance technology, thermal effusivity and various particle...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2020-12-01
|
| Series: | Acta Pharmaceutica |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/acph-2020-0038 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832572494866808832 |
|---|---|
| author | Vovko Aleša Dular Vrečer Franc |
| author_facet | Vovko Aleša Dular Vrečer Franc |
| author_sort | Vovko Aleša Dular |
| collection | DOAJ |
| description | This article presents an overview of using process analytical technology in monitoring the roller compaction process. In the past two decades, near-infrared spectroscopy, near-infrared spectroscopy coupled with chemical imaging, microwave resonance technology, thermal effusivity and various particle imaging techniques have been used for developing at-, off-, on- and in-line models for predicting critical quality attributes of ribbons and subsequent granules and tablets. The common goal of all these methods is improved process understanding and process control, and thus improved production of high-quality products. This article reviews the work of several researchers in this field, comparing and critically evaluating their achievements. |
| format | Article |
| id | doaj-art-8c961b08e1d74a82b0975bf8bf008c54 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2020-12-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-8c961b08e1d74a82b0975bf8bf008c542025-02-02T09:52:47ZengSciendoActa Pharmaceutica1846-95582020-12-0170444346310.2478/acph-2020-0038acph-2020-0038Process analytical technology tools for process control of roller compaction in solid pharmaceuticals manufacturingVovko Aleša Dular0Vrečer Franc1Krka, d.d. Novo mesto, 8501 Novo mesto, SloveniaKrka, d.d. Novo mesto, 8501 Novo mesto, SloveniaThis article presents an overview of using process analytical technology in monitoring the roller compaction process. In the past two decades, near-infrared spectroscopy, near-infrared spectroscopy coupled with chemical imaging, microwave resonance technology, thermal effusivity and various particle imaging techniques have been used for developing at-, off-, on- and in-line models for predicting critical quality attributes of ribbons and subsequent granules and tablets. The common goal of all these methods is improved process understanding and process control, and thus improved production of high-quality products. This article reviews the work of several researchers in this field, comparing and critically evaluating their achievements.https://doi.org/10.2478/acph-2020-0038process analytical technology (pat)roller compactionnear-infrared (nir) spectroscopynear-infrared chemical imaging (nir-ci)microwave resonance technologythermal effusivity |
| spellingShingle | Vovko Aleša Dular Vrečer Franc Process analytical technology tools for process control of roller compaction in solid pharmaceuticals manufacturing Acta Pharmaceutica process analytical technology (pat) roller compaction near-infrared (nir) spectroscopy near-infrared chemical imaging (nir-ci) microwave resonance technology thermal effusivity |
| title | Process analytical technology tools for process control of roller compaction in solid pharmaceuticals manufacturing |
| title_full | Process analytical technology tools for process control of roller compaction in solid pharmaceuticals manufacturing |
| title_fullStr | Process analytical technology tools for process control of roller compaction in solid pharmaceuticals manufacturing |
| title_full_unstemmed | Process analytical technology tools for process control of roller compaction in solid pharmaceuticals manufacturing |
| title_short | Process analytical technology tools for process control of roller compaction in solid pharmaceuticals manufacturing |
| title_sort | process analytical technology tools for process control of roller compaction in solid pharmaceuticals manufacturing |
| topic | process analytical technology (pat) roller compaction near-infrared (nir) spectroscopy near-infrared chemical imaging (nir-ci) microwave resonance technology thermal effusivity |
| url | https://doi.org/10.2478/acph-2020-0038 |
| work_keys_str_mv | AT vovkoalesadular processanalyticaltechnologytoolsforprocesscontrolofrollercompactioninsolidpharmaceuticalsmanufacturing AT vrecerfranc processanalyticaltechnologytoolsforprocesscontrolofrollercompactioninsolidpharmaceuticalsmanufacturing |