Engineering a halloysite nanotube-enhanced hydrogel 3D skin model for modulated inflammation and accelerated wound healing
The medicine field continues to encounter obstacles in understanding the etiology of skin inflammation and the process of skin wound repair. Developing sustainable and effective three-dimensional (3D) skin models for investigating inflammatory skin biology remains a challenge. By incorporating hallo...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2025-03-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X24004973 |
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| author | Rui Xu Xihong Fu Lerong Lun Wenjing Jiang Xuemei Situ Xiaobao Huang Ying Xiong Chun Liu Fang Wang |
| author_facet | Rui Xu Xihong Fu Lerong Lun Wenjing Jiang Xuemei Situ Xiaobao Huang Ying Xiong Chun Liu Fang Wang |
| author_sort | Rui Xu |
| collection | DOAJ |
| description | The medicine field continues to encounter obstacles in understanding the etiology of skin inflammation and the process of skin wound repair. Developing sustainable and effective three-dimensional (3D) skin models for investigating inflammatory skin biology remains a challenge. By incorporating halloysite nanotubes (HNT) into a composite collagen/alginate/hyaluronic acid hydrogel, we created a novel 3D skin model and introduced keratinocytes and fibroblast cells into it. We demonstrate that the modified 3D skin model is capable of enhancing the differentiation and adhesion behaviors of keratinocytes and fibroblast cells in vitro and promoting wound healing in vivo. These characteristics highlight the potential of this approach for the study of skin inflammation, wound healing, regeneration, aging, and beyond. |
| format | Article |
| id | doaj-art-8c951a262a1f47d298c85c2881ef80a9 |
| institution | Kabale University |
| issn | 2452-199X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj-art-8c951a262a1f47d298c85c2881ef80a92025-01-26T05:04:21ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2025-03-0145148161Engineering a halloysite nanotube-enhanced hydrogel 3D skin model for modulated inflammation and accelerated wound healingRui Xu0Xihong Fu1Lerong Lun2Wenjing Jiang3Xuemei Situ4Xiaobao Huang5Ying Xiong6Chun Liu7Fang Wang8Department of Dermatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510080, ChinaGuangdong Provincial Key Laboratory of Orthopedics and Traumatology, Department of Spinal Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510080, ChinaDepartment of Dermatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510080, ChinaDepartment of Dermatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510080, ChinaDepartment of Dermatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510080, ChinaDepartment of Dermatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510080, ChinaDepartment of Anesthesiology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, 510080, ChinaInstitute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510080, China; Corresponding author.Department of Dermatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510080, China; Dermatology Hospital, Southern Medical University, Guangzhou, Guangdong, 510091, China; Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangdong, 510060, China; Corresponding author. Department of Dermatology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.The medicine field continues to encounter obstacles in understanding the etiology of skin inflammation and the process of skin wound repair. Developing sustainable and effective three-dimensional (3D) skin models for investigating inflammatory skin biology remains a challenge. By incorporating halloysite nanotubes (HNT) into a composite collagen/alginate/hyaluronic acid hydrogel, we created a novel 3D skin model and introduced keratinocytes and fibroblast cells into it. We demonstrate that the modified 3D skin model is capable of enhancing the differentiation and adhesion behaviors of keratinocytes and fibroblast cells in vitro and promoting wound healing in vivo. These characteristics highlight the potential of this approach for the study of skin inflammation, wound healing, regeneration, aging, and beyond.http://www.sciencedirect.com/science/article/pii/S2452199X24004973HydrogelHalloysite nanotubesSkinInflammationWound healing |
| spellingShingle | Rui Xu Xihong Fu Lerong Lun Wenjing Jiang Xuemei Situ Xiaobao Huang Ying Xiong Chun Liu Fang Wang Engineering a halloysite nanotube-enhanced hydrogel 3D skin model for modulated inflammation and accelerated wound healing Bioactive Materials Hydrogel Halloysite nanotubes Skin Inflammation Wound healing |
| title | Engineering a halloysite nanotube-enhanced hydrogel 3D skin model for modulated inflammation and accelerated wound healing |
| title_full | Engineering a halloysite nanotube-enhanced hydrogel 3D skin model for modulated inflammation and accelerated wound healing |
| title_fullStr | Engineering a halloysite nanotube-enhanced hydrogel 3D skin model for modulated inflammation and accelerated wound healing |
| title_full_unstemmed | Engineering a halloysite nanotube-enhanced hydrogel 3D skin model for modulated inflammation and accelerated wound healing |
| title_short | Engineering a halloysite nanotube-enhanced hydrogel 3D skin model for modulated inflammation and accelerated wound healing |
| title_sort | engineering a halloysite nanotube enhanced hydrogel 3d skin model for modulated inflammation and accelerated wound healing |
| topic | Hydrogel Halloysite nanotubes Skin Inflammation Wound healing |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X24004973 |
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