Bcl-2 and Bcl-xL in Diabetes: Contributions to Endocrine Pancreas Viability and Function
Diabetes is a chronic metabolic disorder whose prevalence increases every year, affecting more than 530 million adults worldwide. Type 1 (T1D) and type 2 diabetes (T2D), the most common forms of diabetes, are characterized by the loss of functional pancreatic β-cells, mostly due to apoptosis. B-cell...
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MDPI AG
2025-01-01
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| author | Atenea A. Perez-Serna Daniel Guzman-Llorens Reinaldo S. Dos Santos Laura Marroqui |
| author_facet | Atenea A. Perez-Serna Daniel Guzman-Llorens Reinaldo S. Dos Santos Laura Marroqui |
| author_sort | Atenea A. Perez-Serna |
| collection | DOAJ |
| description | Diabetes is a chronic metabolic disorder whose prevalence increases every year, affecting more than 530 million adults worldwide. Type 1 (T1D) and type 2 diabetes (T2D), the most common forms of diabetes, are characterized by the loss of functional pancreatic β-cells, mostly due to apoptosis. B-cell leukemia/lymphoma 2 (Bcl-2) and B-cell lymphoma-extra large (Bcl-xL), two anti-apoptotic proteins belonging to the Bcl-2 family, are crucial for regulating the intrinsic pathway of apoptosis. However, over the years, they have been implicated in many other cellular processes, including intracellular Ca<sup>2+</sup> homeostasis and the regulation of mitochondrial metabolism. Thus, understanding the biological processes in which these proteins are involved may be crucial to designing new therapeutic targets. This review summarizes the roles of Bcl-2 and Bcl-xL in apoptosis and metabolic homeostasis. It focuses on how the dysregulation of Bcl-2 and Bcl-xL affects pancreatic β-cell function and survival, and the consequences for diabetes development. |
| format | Article |
| id | doaj-art-8c949e88f4d3466ab1d97723100ab446 |
| institution | Kabale University |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-8c949e88f4d3466ab1d97723100ab4462025-01-24T13:24:27ZengMDPI AGBiomedicines2227-90592025-01-0113122310.3390/biomedicines13010223Bcl-2 and Bcl-xL in Diabetes: Contributions to Endocrine Pancreas Viability and FunctionAtenea A. Perez-Serna0Daniel Guzman-Llorens1Reinaldo S. Dos Santos2Laura Marroqui3Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Universidad Miguel Hernández de Elche, 03202 Elche, Alicante, SpainInstituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Universidad Miguel Hernández de Elche, 03202 Elche, Alicante, SpainInstituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Universidad Miguel Hernández de Elche, 03202 Elche, Alicante, SpainInstituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Universidad Miguel Hernández de Elche, 03202 Elche, Alicante, SpainDiabetes is a chronic metabolic disorder whose prevalence increases every year, affecting more than 530 million adults worldwide. Type 1 (T1D) and type 2 diabetes (T2D), the most common forms of diabetes, are characterized by the loss of functional pancreatic β-cells, mostly due to apoptosis. B-cell leukemia/lymphoma 2 (Bcl-2) and B-cell lymphoma-extra large (Bcl-xL), two anti-apoptotic proteins belonging to the Bcl-2 family, are crucial for regulating the intrinsic pathway of apoptosis. However, over the years, they have been implicated in many other cellular processes, including intracellular Ca<sup>2+</sup> homeostasis and the regulation of mitochondrial metabolism. Thus, understanding the biological processes in which these proteins are involved may be crucial to designing new therapeutic targets. This review summarizes the roles of Bcl-2 and Bcl-xL in apoptosis and metabolic homeostasis. It focuses on how the dysregulation of Bcl-2 and Bcl-xL affects pancreatic β-cell function and survival, and the consequences for diabetes development.https://www.mdpi.com/2227-9059/13/1/223apoptosisBcl-xLBcl-2diabeteshormone secretionpancreatic β-cells |
| spellingShingle | Atenea A. Perez-Serna Daniel Guzman-Llorens Reinaldo S. Dos Santos Laura Marroqui Bcl-2 and Bcl-xL in Diabetes: Contributions to Endocrine Pancreas Viability and Function Biomedicines apoptosis Bcl-xL Bcl-2 diabetes hormone secretion pancreatic β-cells |
| title | Bcl-2 and Bcl-xL in Diabetes: Contributions to Endocrine Pancreas Viability and Function |
| title_full | Bcl-2 and Bcl-xL in Diabetes: Contributions to Endocrine Pancreas Viability and Function |
| title_fullStr | Bcl-2 and Bcl-xL in Diabetes: Contributions to Endocrine Pancreas Viability and Function |
| title_full_unstemmed | Bcl-2 and Bcl-xL in Diabetes: Contributions to Endocrine Pancreas Viability and Function |
| title_short | Bcl-2 and Bcl-xL in Diabetes: Contributions to Endocrine Pancreas Viability and Function |
| title_sort | bcl 2 and bcl xl in diabetes contributions to endocrine pancreas viability and function |
| topic | apoptosis Bcl-xL Bcl-2 diabetes hormone secretion pancreatic β-cells |
| url | https://www.mdpi.com/2227-9059/13/1/223 |
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