Advances in functional MRI research in bipolar disorder: from the perspective of mood states
Bipolar disorder is characterised by recurrent and alternating episodes of mania/hypomania and depression. Current breakthroughs in functional MRI techniques have uncovered the functional neuroanatomy of bipolar disorder. However, the pathophysiology underlying mood instability, mood switching and t...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2024-02-01
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| Series: | General Psychiatry |
| Online Access: | https://gpsych.bmj.com/content/37/1/e101398.full |
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| author | Yun-Ai Su Tianmei Si Yankun Wu Linlin Zhu Jitao Li |
| author_facet | Yun-Ai Su Tianmei Si Yankun Wu Linlin Zhu Jitao Li |
| author_sort | Yun-Ai Su |
| collection | DOAJ |
| description | Bipolar disorder is characterised by recurrent and alternating episodes of mania/hypomania and depression. Current breakthroughs in functional MRI techniques have uncovered the functional neuroanatomy of bipolar disorder. However, the pathophysiology underlying mood instability, mood switching and the development of extreme mood states is less well understood. This review presents a comprehensive overview of current evidence from functional MRI studies from the perspective of mood states. We first summarise the disrupted brain activation patterns and functional connectivity that have been reported in bipolar disorder, irrespective of the mood state. We next focus on research that solely included patients in a single mood state for a better understanding of the pathophysiology of bipolar disorder and research comparing patients with different mood states to dissect mood state-related effects. Finally, we briefly summarise current theoretical models and conclude this review by proposing potential avenues for future research. A comprehensive understanding of the pathophysiology with consideration of mood states could not only deepen our understanding of how acute mood episodes develop at a neurophysiological level but could also facilitate the identification of biological targets for personalised treatment and the development of new interventions for bipolar disorder. |
| format | Article |
| id | doaj-art-8c790f631d7943cebd1e4486ee142b12 |
| institution | Kabale University |
| issn | 2517-729X |
| language | English |
| publishDate | 2024-02-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | General Psychiatry |
| spelling | doaj-art-8c790f631d7943cebd1e4486ee142b122025-01-29T15:30:09ZengBMJ Publishing GroupGeneral Psychiatry2517-729X2024-02-0137110.1136/gpsych-2023-101398Advances in functional MRI research in bipolar disorder: from the perspective of mood statesYun-Ai Su0Tianmei Si1Yankun Wu2Linlin Zhu3Jitao Li42 Department of Clinical Psychopharmacology, Peking University Institute of Mental Health, Beijing, People`s Republic of China3 Neuropsychopharmacology, Peking University Institute of Mental Health, Beijing, China1 Department of Clinical Psychopharmacology, Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, China1 Department of Clinical Psychopharmacology, Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, China1 Department of Clinical Psychopharmacology, Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, ChinaBipolar disorder is characterised by recurrent and alternating episodes of mania/hypomania and depression. Current breakthroughs in functional MRI techniques have uncovered the functional neuroanatomy of bipolar disorder. However, the pathophysiology underlying mood instability, mood switching and the development of extreme mood states is less well understood. This review presents a comprehensive overview of current evidence from functional MRI studies from the perspective of mood states. We first summarise the disrupted brain activation patterns and functional connectivity that have been reported in bipolar disorder, irrespective of the mood state. We next focus on research that solely included patients in a single mood state for a better understanding of the pathophysiology of bipolar disorder and research comparing patients with different mood states to dissect mood state-related effects. Finally, we briefly summarise current theoretical models and conclude this review by proposing potential avenues for future research. A comprehensive understanding of the pathophysiology with consideration of mood states could not only deepen our understanding of how acute mood episodes develop at a neurophysiological level but could also facilitate the identification of biological targets for personalised treatment and the development of new interventions for bipolar disorder.https://gpsych.bmj.com/content/37/1/e101398.full |
| spellingShingle | Yun-Ai Su Tianmei Si Yankun Wu Linlin Zhu Jitao Li Advances in functional MRI research in bipolar disorder: from the perspective of mood states General Psychiatry |
| title | Advances in functional MRI research in bipolar disorder: from the perspective of mood states |
| title_full | Advances in functional MRI research in bipolar disorder: from the perspective of mood states |
| title_fullStr | Advances in functional MRI research in bipolar disorder: from the perspective of mood states |
| title_full_unstemmed | Advances in functional MRI research in bipolar disorder: from the perspective of mood states |
| title_short | Advances in functional MRI research in bipolar disorder: from the perspective of mood states |
| title_sort | advances in functional mri research in bipolar disorder from the perspective of mood states |
| url | https://gpsych.bmj.com/content/37/1/e101398.full |
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