Preimplantation genetic testing might not be the necessity for male patients with 47,XYY syndrome: A pilot study
Abstract Purpose This pilot study aimed to explore the necessity for 47,XYY syndrome males (couples) to perform PGT rather than conventional In Vitro Fertilization (IVF)/Intracytoplasmic Sperm Injection (ICSI) cycles. Methods A retrospective cohort study was conducted with 36 nonmosaic and mosaic 47...
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2025-01-01
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| Series: | Reproductive Medicine and Biology |
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| Online Access: | https://doi.org/10.1002/rmb2.12650 |
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| author | Fan Dong Zhong Zheng Ying Ding Yi Ma Si‐Qi Wang Xiang‐Feng Chen Ping Ping |
| author_facet | Fan Dong Zhong Zheng Ying Ding Yi Ma Si‐Qi Wang Xiang‐Feng Chen Ping Ping |
| author_sort | Fan Dong |
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| description | Abstract Purpose This pilot study aimed to explore the necessity for 47,XYY syndrome males (couples) to perform PGT rather than conventional In Vitro Fertilization (IVF)/Intracytoplasmic Sperm Injection (ICSI) cycles. Methods A retrospective cohort study was conducted with 36 nonmosaic and mosaic 47,XYY syndrome patients (couples) undergoing 43 oocyte retrieval cycles (37 planned for PGT and 6 for IVF/ICSI) between December 2017 and December 2023. The couples were given either next‐generation sequencing‐based PGT or conventional IVF/ICSI followed by 45 embryo transfer (ET) cycles (38 from PGT and 7 from IVF/ICSI). The detailed cytogenetic results of the 129 embryos from PGT were analyzed, and the pregnancy and neonatal outcomes between PGT‐ET and conventional IVF/ICSI‐ET cycles were compared. Results The PGT results showed that the chance of sex chromosome abnormalities was low (1.55%), with chromosomal errors being observed more often in autosomes. Importantly, no differences were observed in the rates of biochemical pregnancy, implantation, clinical pregnancy, ongoing pregnancy, pregnancy loss, live birth, and preterm delivery between PGT‐ET cycles and conventional IVF/ICSI‐ET cycles. Comparable results regarding gestational age, birthweight, low birthweight rate, macrosomia rate, male rate, as well as the rate of congenital anomalies were also observed between the two groups. Conclusions Preimplantation genetic testing might not be necessary to conduct for 47,XYY syndrome males unless there are other indications. Studies with large populations are in demand to confirm the present results. |
| format | Article |
| id | doaj-art-8c73ccd00a5e45c49f3741151e42eccb |
| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
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| series | Reproductive Medicine and Biology |
| spelling | doaj-art-8c73ccd00a5e45c49f3741151e42eccb2025-08-20T06:16:47ZengWileyReproductive Medicine and Biology1445-57811447-05782025-01-01241n/an/a10.1002/rmb2.12650Preimplantation genetic testing might not be the necessity for male patients with 47,XYY syndrome: A pilot studyFan Dong0Zhong Zheng1Ying Ding2Yi Ma3Si‐Qi Wang4Xiang‐Feng Chen5Ping Ping6Department of Reproductive Medicine, Ren Ji Hospital Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Reproductive Medicine, Ren Ji Hospital Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Reproductive Medicine, Ren Ji Hospital Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Reproductive Medicine, Ren Ji Hospital Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Reproductive Medicine, Ren Ji Hospital Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Reproductive Medicine, Ren Ji Hospital Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Reproductive Medicine, Ren Ji Hospital Shanghai Jiao Tong University School of Medicine Shanghai ChinaAbstract Purpose This pilot study aimed to explore the necessity for 47,XYY syndrome males (couples) to perform PGT rather than conventional In Vitro Fertilization (IVF)/Intracytoplasmic Sperm Injection (ICSI) cycles. Methods A retrospective cohort study was conducted with 36 nonmosaic and mosaic 47,XYY syndrome patients (couples) undergoing 43 oocyte retrieval cycles (37 planned for PGT and 6 for IVF/ICSI) between December 2017 and December 2023. The couples were given either next‐generation sequencing‐based PGT or conventional IVF/ICSI followed by 45 embryo transfer (ET) cycles (38 from PGT and 7 from IVF/ICSI). The detailed cytogenetic results of the 129 embryos from PGT were analyzed, and the pregnancy and neonatal outcomes between PGT‐ET and conventional IVF/ICSI‐ET cycles were compared. Results The PGT results showed that the chance of sex chromosome abnormalities was low (1.55%), with chromosomal errors being observed more often in autosomes. Importantly, no differences were observed in the rates of biochemical pregnancy, implantation, clinical pregnancy, ongoing pregnancy, pregnancy loss, live birth, and preterm delivery between PGT‐ET cycles and conventional IVF/ICSI‐ET cycles. Comparable results regarding gestational age, birthweight, low birthweight rate, macrosomia rate, male rate, as well as the rate of congenital anomalies were also observed between the two groups. Conclusions Preimplantation genetic testing might not be necessary to conduct for 47,XYY syndrome males unless there are other indications. Studies with large populations are in demand to confirm the present results.https://doi.org/10.1002/rmb2.1265047,XYY syndromeIVF/ICSIneonatal outcomespregnancy outcomespreimplantation genetic testing |
| spellingShingle | Fan Dong Zhong Zheng Ying Ding Yi Ma Si‐Qi Wang Xiang‐Feng Chen Ping Ping Preimplantation genetic testing might not be the necessity for male patients with 47,XYY syndrome: A pilot study Reproductive Medicine and Biology 47,XYY syndrome IVF/ICSI neonatal outcomes pregnancy outcomes preimplantation genetic testing |
| title | Preimplantation genetic testing might not be the necessity for male patients with 47,XYY syndrome: A pilot study |
| title_full | Preimplantation genetic testing might not be the necessity for male patients with 47,XYY syndrome: A pilot study |
| title_fullStr | Preimplantation genetic testing might not be the necessity for male patients with 47,XYY syndrome: A pilot study |
| title_full_unstemmed | Preimplantation genetic testing might not be the necessity for male patients with 47,XYY syndrome: A pilot study |
| title_short | Preimplantation genetic testing might not be the necessity for male patients with 47,XYY syndrome: A pilot study |
| title_sort | preimplantation genetic testing might not be the necessity for male patients with 47 xyy syndrome a pilot study |
| topic | 47,XYY syndrome IVF/ICSI neonatal outcomes pregnancy outcomes preimplantation genetic testing |
| url | https://doi.org/10.1002/rmb2.12650 |
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