Effect of Obesity-Linked FTO rs9939609 Variant on Physical Activity and Dietary Patterns in Physically Active Men and Women
Single nucleotide polymorphisms (SNPs) in the fat mass and obesity-associated (FTO) locus are associated with obesity, but lifestyle factors may modulate the obesity risk related to FTO. This study examined the physical activity and dietary patterns of 528 physically active white men and women (mean...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2018/7560707 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832568088097193984 |
|---|---|
| author | Nathan R. West James Dorling Alice E. Thackray Nicola C. Hanson Samantha E. Decombel David J. Stensel Stuart J. Grice |
| author_facet | Nathan R. West James Dorling Alice E. Thackray Nicola C. Hanson Samantha E. Decombel David J. Stensel Stuart J. Grice |
| author_sort | Nathan R. West |
| collection | DOAJ |
| description | Single nucleotide polymorphisms (SNPs) in the fat mass and obesity-associated (FTO) locus are associated with obesity, but lifestyle factors may modulate the obesity risk related to FTO. This study examined the physical activity and dietary patterns of 528 physically active white men and women (mean (SD): 34.9 (9.5) years, 26.6 (4.3) kg·m−2) carrying different risk variants of FTO SNP rs9939609. Sex, age, and anthropometric measurements (stature, body mass, and waist circumference) were self-reported using an online questionnaire, and body mass index and waist-to-height ratio were calculated. Physical activity and eating behaviour were assessed using the International Physical Activity Questionnaire (IPAQ) and Three-Factor Eating Questionnaire (TFEQ), respectively. Body mass, body mass index (BMI), waist circumference, and waist-to-height ratio were not significantly different between individuals expressing different FTO rs9939609 risk variants (all P≥0.66). The cohort was physically active (4516 (3043) total MET min·week−1), although homozygous risk allele carriers (AA) displayed higher TFEQ cognitive restraint compared with nonrisk allele carriers (TT) (ES = 0.33 and P=0.03). In conclusion, obesity-related parameters were not different in physically active individuals expressing different risk variants of FTO rs9939609, although homozygous risk allele carriers exhibited higher cognitive restraint. |
| format | Article |
| id | doaj-art-8c72f59803064a78a71220b93c904b9e |
| institution | Kabale University |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-8c72f59803064a78a71220b93c904b9e2025-02-03T00:59:46ZengWileyJournal of Obesity2090-07082090-07162018-01-01201810.1155/2018/75607077560707Effect of Obesity-Linked FTO rs9939609 Variant on Physical Activity and Dietary Patterns in Physically Active Men and WomenNathan R. West0James Dorling1Alice E. Thackray2Nicola C. Hanson3Samantha E. Decombel4David J. Stensel5Stuart J. Grice6FitnessGenes, Bicester Innovation Centre, Commerce House, Telford Rd., Bicester OX26 4LD, UKSchool of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, Leicestershire LE11 3TU, UKSchool of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, Leicestershire LE11 3TU, UKFitnessGenes, Bicester Innovation Centre, Commerce House, Telford Rd., Bicester OX26 4LD, UKFitnessGenes, Bicester Innovation Centre, Commerce House, Telford Rd., Bicester OX26 4LD, UKSchool of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, Leicestershire LE11 3TU, UKFitnessGenes, Bicester Innovation Centre, Commerce House, Telford Rd., Bicester OX26 4LD, UKSingle nucleotide polymorphisms (SNPs) in the fat mass and obesity-associated (FTO) locus are associated with obesity, but lifestyle factors may modulate the obesity risk related to FTO. This study examined the physical activity and dietary patterns of 528 physically active white men and women (mean (SD): 34.9 (9.5) years, 26.6 (4.3) kg·m−2) carrying different risk variants of FTO SNP rs9939609. Sex, age, and anthropometric measurements (stature, body mass, and waist circumference) were self-reported using an online questionnaire, and body mass index and waist-to-height ratio were calculated. Physical activity and eating behaviour were assessed using the International Physical Activity Questionnaire (IPAQ) and Three-Factor Eating Questionnaire (TFEQ), respectively. Body mass, body mass index (BMI), waist circumference, and waist-to-height ratio were not significantly different between individuals expressing different FTO rs9939609 risk variants (all P≥0.66). The cohort was physically active (4516 (3043) total MET min·week−1), although homozygous risk allele carriers (AA) displayed higher TFEQ cognitive restraint compared with nonrisk allele carriers (TT) (ES = 0.33 and P=0.03). In conclusion, obesity-related parameters were not different in physically active individuals expressing different risk variants of FTO rs9939609, although homozygous risk allele carriers exhibited higher cognitive restraint.http://dx.doi.org/10.1155/2018/7560707 |
| spellingShingle | Nathan R. West James Dorling Alice E. Thackray Nicola C. Hanson Samantha E. Decombel David J. Stensel Stuart J. Grice Effect of Obesity-Linked FTO rs9939609 Variant on Physical Activity and Dietary Patterns in Physically Active Men and Women Journal of Obesity |
| title | Effect of Obesity-Linked FTO rs9939609 Variant on Physical Activity and Dietary Patterns in Physically Active Men and Women |
| title_full | Effect of Obesity-Linked FTO rs9939609 Variant on Physical Activity and Dietary Patterns in Physically Active Men and Women |
| title_fullStr | Effect of Obesity-Linked FTO rs9939609 Variant on Physical Activity and Dietary Patterns in Physically Active Men and Women |
| title_full_unstemmed | Effect of Obesity-Linked FTO rs9939609 Variant on Physical Activity and Dietary Patterns in Physically Active Men and Women |
| title_short | Effect of Obesity-Linked FTO rs9939609 Variant on Physical Activity and Dietary Patterns in Physically Active Men and Women |
| title_sort | effect of obesity linked fto rs9939609 variant on physical activity and dietary patterns in physically active men and women |
| url | http://dx.doi.org/10.1155/2018/7560707 |
| work_keys_str_mv | AT nathanrwest effectofobesitylinkedftors9939609variantonphysicalactivityanddietarypatternsinphysicallyactivemenandwomen AT jamesdorling effectofobesitylinkedftors9939609variantonphysicalactivityanddietarypatternsinphysicallyactivemenandwomen AT aliceethackray effectofobesitylinkedftors9939609variantonphysicalactivityanddietarypatternsinphysicallyactivemenandwomen AT nicolachanson effectofobesitylinkedftors9939609variantonphysicalactivityanddietarypatternsinphysicallyactivemenandwomen AT samanthaedecombel effectofobesitylinkedftors9939609variantonphysicalactivityanddietarypatternsinphysicallyactivemenandwomen AT davidjstensel effectofobesitylinkedftors9939609variantonphysicalactivityanddietarypatternsinphysicallyactivemenandwomen AT stuartjgrice effectofobesitylinkedftors9939609variantonphysicalactivityanddietarypatternsinphysicallyactivemenandwomen |