Impact of Abdominal Obesity on Thyroid Auto-Antibody Positivity: Abdominal Obesity Can Enhance the Risk of Thyroid Autoimmunity in Men
Background. The interrelation between obesity and autoimmune thyroid diseases is complex and has not been confirmed. The aim of the present study was to observe the relationship between thyroid autoimmunity and obesity, especially abdominal obesity, in a large population. Methods. A total of 2253 re...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2020/6816198 |
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| author | Jazyra Zynat Suli Li Yanrong Ma Li Han Fuhui Ma Yuyuan Zhang Bei Xing Xinling Wang Yanying Guo |
| author_facet | Jazyra Zynat Suli Li Yanrong Ma Li Han Fuhui Ma Yuyuan Zhang Bei Xing Xinling Wang Yanying Guo |
| author_sort | Jazyra Zynat |
| collection | DOAJ |
| description | Background. The interrelation between obesity and autoimmune thyroid diseases is complex and has not been confirmed. The aim of the present study was to observe the relationship between thyroid autoimmunity and obesity, especially abdominal obesity, in a large population. Methods. A total of 2253 residents who had lived in Xinjiang for more than 3 years were enrolled. Serum thyroid hormone concentration, thyroid autoantibodies, lipid parameters, Weight, height, and waist and hip circumference were measured. Results. The prevalence of thyroid peroxidase antibody (TPOAb) and/or thyroglobulin antibody (TgAb) positive was 32.1% (21.2% in men and 37% in women, P<0.01). Compared with women, men had significantly higher TG levels, waist circumference, and hip circumference levels (P<0.01), while women showed higher TSH, TPOAb, and TgAb levels (P<0.01). The prevalence of overweight and obesity was 71.1% in men and 63.5% in women. Men had a higher prevalence of abdominal obesity than women (56.6% in men and 47.6% in women, P<0.01). TPOAb correlates positively with waist circumference (r = 0.100, P<0.05) in men. Binary logistic analysis showed that TPOAb positivity had increased risks of abdominal obesity in men, and the OR was 1.1044 (95% CI 1.035, 1.151, P<0.05). Conclusion. Our results indicate that men had higher lipid levels, thicker waist circumference, and higher prevalence of overweight, obesity, and abdominal obesity. Abdominal obesity is a risk factor for TPOAb positivity in men, suggesting that abdominal obesity can enhance the risk of thyroid autoimmunity in men. |
| format | Article |
| id | doaj-art-8c64b6bbb61746c4b959dd1f18768952 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-8c64b6bbb61746c4b959dd1f187689522025-02-03T01:28:21ZengWileyInternational Journal of Endocrinology1687-83371687-83452020-01-01202010.1155/2020/68161986816198Impact of Abdominal Obesity on Thyroid Auto-Antibody Positivity: Abdominal Obesity Can Enhance the Risk of Thyroid Autoimmunity in MenJazyra Zynat0Suli Li1Yanrong Ma2Li Han3Fuhui Ma4Yuyuan Zhang5Bei Xing6Xinling Wang7Yanying Guo8Department of Endocrinology, People’s Hospital of Xinjiang Uygur Autonomous Region, Ürümqi, Xinjiang, ChinaDepartment of Endocrinology, People’s Hospital of Xinjiang Uygur Autonomous Region, Ürümqi, Xinjiang, ChinaDepartment of Endocrinology, People’s Hospital of Xinjiang Uygur Autonomous Region, Ürümqi, Xinjiang, ChinaDepartment of Endocrinology, People’s Hospital of Xinjiang Uygur Autonomous Region, Ürümqi, Xinjiang, ChinaDepartment of Endocrinology, People’s Hospital of Xinjiang Uygur Autonomous Region, Ürümqi, Xinjiang, ChinaDepartment of Endocrinology, People’s Hospital of Xinjiang Uygur Autonomous Region, Ürümqi, Xinjiang, ChinaDepartment of Endocrinology, People’s Hospital of Xinjiang Uygur Autonomous Region, Ürümqi, Xinjiang, ChinaDepartment of Endocrinology, People’s Hospital of Xinjiang Uygur Autonomous Region, Ürümqi, Xinjiang, ChinaDepartment of Endocrinology, People’s Hospital of Xinjiang Uygur Autonomous Region, Ürümqi, Xinjiang, ChinaBackground. The interrelation between obesity and autoimmune thyroid diseases is complex and has not been confirmed. The aim of the present study was to observe the relationship between thyroid autoimmunity and obesity, especially abdominal obesity, in a large population. Methods. A total of 2253 residents who had lived in Xinjiang for more than 3 years were enrolled. Serum thyroid hormone concentration, thyroid autoantibodies, lipid parameters, Weight, height, and waist and hip circumference were measured. Results. The prevalence of thyroid peroxidase antibody (TPOAb) and/or thyroglobulin antibody (TgAb) positive was 32.1% (21.2% in men and 37% in women, P<0.01). Compared with women, men had significantly higher TG levels, waist circumference, and hip circumference levels (P<0.01), while women showed higher TSH, TPOAb, and TgAb levels (P<0.01). The prevalence of overweight and obesity was 71.1% in men and 63.5% in women. Men had a higher prevalence of abdominal obesity than women (56.6% in men and 47.6% in women, P<0.01). TPOAb correlates positively with waist circumference (r = 0.100, P<0.05) in men. Binary logistic analysis showed that TPOAb positivity had increased risks of abdominal obesity in men, and the OR was 1.1044 (95% CI 1.035, 1.151, P<0.05). Conclusion. Our results indicate that men had higher lipid levels, thicker waist circumference, and higher prevalence of overweight, obesity, and abdominal obesity. Abdominal obesity is a risk factor for TPOAb positivity in men, suggesting that abdominal obesity can enhance the risk of thyroid autoimmunity in men.http://dx.doi.org/10.1155/2020/6816198 |
| spellingShingle | Jazyra Zynat Suli Li Yanrong Ma Li Han Fuhui Ma Yuyuan Zhang Bei Xing Xinling Wang Yanying Guo Impact of Abdominal Obesity on Thyroid Auto-Antibody Positivity: Abdominal Obesity Can Enhance the Risk of Thyroid Autoimmunity in Men International Journal of Endocrinology |
| title | Impact of Abdominal Obesity on Thyroid Auto-Antibody Positivity: Abdominal Obesity Can Enhance the Risk of Thyroid Autoimmunity in Men |
| title_full | Impact of Abdominal Obesity on Thyroid Auto-Antibody Positivity: Abdominal Obesity Can Enhance the Risk of Thyroid Autoimmunity in Men |
| title_fullStr | Impact of Abdominal Obesity on Thyroid Auto-Antibody Positivity: Abdominal Obesity Can Enhance the Risk of Thyroid Autoimmunity in Men |
| title_full_unstemmed | Impact of Abdominal Obesity on Thyroid Auto-Antibody Positivity: Abdominal Obesity Can Enhance the Risk of Thyroid Autoimmunity in Men |
| title_short | Impact of Abdominal Obesity on Thyroid Auto-Antibody Positivity: Abdominal Obesity Can Enhance the Risk of Thyroid Autoimmunity in Men |
| title_sort | impact of abdominal obesity on thyroid auto antibody positivity abdominal obesity can enhance the risk of thyroid autoimmunity in men |
| url | http://dx.doi.org/10.1155/2020/6816198 |
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