Negative regulation of miRNA sorting into EVs is mediated by the capacity of RBP PCBP2 to impair the SYNCRIP-dependent miRNA loading

Negative regulation of miRNA sorting into EVs is mediated by the capacity of RBP PCBP2 to impair the SYNCRIP-dependent miRNA loading

While it is accepted that extracellular vesicles (EVs)-mediated transfer of microRNAs contributes to intercellular communication, the knowledge about molecular mechanisms controlling the selective and dynamic miRNA-loading in EVs is still limited to few specific RNA-binding proteins interacting with...

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Main Authors: Francesco Marocco, Sabrina Garbo, Claudia Montaldo, Alessio Colantoni, Luca Quattrocchi, Gioele Gaboardi, Giovanna Sabarese, Carla Cicchini, Mario Lecce, Alessia Carnevale, Rossella Paolini, Gian Gaetano Tartaglia, Cecilia Battistelli, Marco Tripodi
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-07-01
Series:eLife
Subjects:
miRNA
RNA-binding proteins
extracellular vesicles
Online Access:https://elifesciences.org/articles/105017
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