Anti-Inflammatory and Organ-Protective Effects of Resveratrol in Trauma-Hemorrhagic Injury
Resveratrol, a natural polyphenolic compound of grape and red wine, owns potential anti-inflammatory effects, which results in the reduction of cytokines overproduction, the inhibition of neutrophil activity, and the alteration of adhesion molecules expression. Resveratrol also possesses antioxidant...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/643763 |
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| author | Fu-Chao Liu Yung-Fong Tsai Hsin-I Tsai Huang-Ping Yu |
| author_facet | Fu-Chao Liu Yung-Fong Tsai Hsin-I Tsai Huang-Ping Yu |
| author_sort | Fu-Chao Liu |
| collection | DOAJ |
| description | Resveratrol, a natural polyphenolic compound of grape and red wine, owns potential anti-inflammatory effects, which results in the reduction of cytokines overproduction, the inhibition of neutrophil activity, and the alteration of adhesion molecules expression. Resveratrol also possesses antioxidant, anti-coagulation and anti-aging properties, and it may control of cell cycle and apoptosis. Resveratrol has been shown to reduce organ damage following traumatic and shock-like states. Such protective phenomenon is reported to be implicated in a variety of intracellular signaling pathways including the activation of estrogen receptor, the regulation of the sirtuin 1/nuclear factor-kappa B and mitogen-activated protein kinases/hemeoxygenase-1 pathway, and the mediation of proinflammatory cytokines and reactive oxygen species formation and reaction. In the recent studies, resveratrol attenuates hepatocyte injury and improves cardiac contractility due to reduction of proinflammatory mediator expression and ameliorates hypoxia-induced liver and kidney mitochondrial dysfunction following trauma and hemorrhagic injuries. Moreover, through anti-inflammatory effects and antioxidant properties, the resveratrol is believed to protect organ function in trauma-hemorrhagic injury. In this review, the organ-protective and anti-inflammatory effects of resveratrol in trauma-hemorrhagic injury will be discussed. |
| format | Article |
| id | doaj-art-8c4a173a4b004b309d5005c107a75d3f |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-8c4a173a4b004b309d5005c107a75d3f2025-02-03T05:53:56ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/643763643763Anti-Inflammatory and Organ-Protective Effects of Resveratrol in Trauma-Hemorrhagic InjuryFu-Chao Liu0Yung-Fong Tsai1Hsin-I Tsai2Huang-Ping Yu3Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan City 333, TaiwanDepartment of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan City 333, TaiwanDepartment of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan City 333, TaiwanDepartment of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan City 333, TaiwanResveratrol, a natural polyphenolic compound of grape and red wine, owns potential anti-inflammatory effects, which results in the reduction of cytokines overproduction, the inhibition of neutrophil activity, and the alteration of adhesion molecules expression. Resveratrol also possesses antioxidant, anti-coagulation and anti-aging properties, and it may control of cell cycle and apoptosis. Resveratrol has been shown to reduce organ damage following traumatic and shock-like states. Such protective phenomenon is reported to be implicated in a variety of intracellular signaling pathways including the activation of estrogen receptor, the regulation of the sirtuin 1/nuclear factor-kappa B and mitogen-activated protein kinases/hemeoxygenase-1 pathway, and the mediation of proinflammatory cytokines and reactive oxygen species formation and reaction. In the recent studies, resveratrol attenuates hepatocyte injury and improves cardiac contractility due to reduction of proinflammatory mediator expression and ameliorates hypoxia-induced liver and kidney mitochondrial dysfunction following trauma and hemorrhagic injuries. Moreover, through anti-inflammatory effects and antioxidant properties, the resveratrol is believed to protect organ function in trauma-hemorrhagic injury. In this review, the organ-protective and anti-inflammatory effects of resveratrol in trauma-hemorrhagic injury will be discussed.http://dx.doi.org/10.1155/2015/643763 |
| spellingShingle | Fu-Chao Liu Yung-Fong Tsai Hsin-I Tsai Huang-Ping Yu Anti-Inflammatory and Organ-Protective Effects of Resveratrol in Trauma-Hemorrhagic Injury Mediators of Inflammation |
| title | Anti-Inflammatory and Organ-Protective Effects of Resveratrol in Trauma-Hemorrhagic Injury |
| title_full | Anti-Inflammatory and Organ-Protective Effects of Resveratrol in Trauma-Hemorrhagic Injury |
| title_fullStr | Anti-Inflammatory and Organ-Protective Effects of Resveratrol in Trauma-Hemorrhagic Injury |
| title_full_unstemmed | Anti-Inflammatory and Organ-Protective Effects of Resveratrol in Trauma-Hemorrhagic Injury |
| title_short | Anti-Inflammatory and Organ-Protective Effects of Resveratrol in Trauma-Hemorrhagic Injury |
| title_sort | anti inflammatory and organ protective effects of resveratrol in trauma hemorrhagic injury |
| url | http://dx.doi.org/10.1155/2015/643763 |
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