Targeting the KLF5/PI3K/AKT axis as a therapeutic strategy to overcome neoadjuvant chemoresistance in colorectal cancer

Targeting the KLF5/PI3K/AKT axis as a therapeutic strategy to overcome neoadjuvant chemoresistance in colorectal cancer

BackgroundOxaliplatin-based neoadjuvant chemotherapy (NAC) is the standard treatment for advanced colorectal cancer (CRC), yet resistance to NAC poses a significant clinical challenge.MethodsTo investigate the mechanisms of chemoresistance, we analyzed single-cell RNA sequencing (scRNA-seq) data fro...

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Main Authors: Meiling Gao, Jiahao Qian, Ping Xia, Wancheng Liu, Yunjia Jiang, Yuchang Xia, Xin Yao, Qingqing Jiao, Minggang Wei
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
colorectal cancer
oxaliplatin resistance
KLF5
GDC-0941
neoadjuvant chemotherapy
PI3K/Akt pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1593639/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1593639/full

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