Exploring the Prognostic Role of Trop-2, CD47, and CD163 Expression Levels on Survival Outcomes in Patients with Triple-Negative Breast Cancer
<b>Background</b>: This study evaluated the prognostic impact of Trop-2, CD47, and CD163 expression on clinical outcomes in triple-negative breast cancer (TNBC) and investigated their interactions with tumor progression. <b>Methods</b>: A retrospective cohort of 92 patients w...
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2025-01-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/15/2/232 |
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| author | Ramazan Oguz Yüceer Sedanur Aydın Iclal Gelir Tulay Koc Ersin Tuncer Mahmut Ucar |
| author_facet | Ramazan Oguz Yüceer Sedanur Aydın Iclal Gelir Tulay Koc Ersin Tuncer Mahmut Ucar |
| author_sort | Ramazan Oguz Yüceer |
| collection | DOAJ |
| description | <b>Background</b>: This study evaluated the prognostic impact of Trop-2, CD47, and CD163 expression on clinical outcomes in triple-negative breast cancer (TNBC) and investigated their interactions with tumor progression. <b>Methods</b>: A retrospective cohort of 92 patients with TNBC was analyzed. The expression scores for Trop-2, CD47, and CD163 were categorized as negative/low (0–3 points) or high (4–6 points). The primary endpoint was overall survival (OS). <b>Results</b>: The median age of the cohort was 50 years old. High Trop-2 expression was observed in 55.4% of the patients and was significantly associated with advanced disease stage (<i>p</i> < 0.001). High CD47 expression (44.6%) was correlated with advanced stage (<i>p</i> = 0.044), whereas high CD163 expression (45.7%) was associated with advanced stage (<i>p</i> = 0.021), absence of comorbidities (<i>p</i> = 0.022), and lower pT stage (<i>p</i> = 0.023). Moderate positive correlations were found between Trop-2 and CD47 (<i>p</i> = 0.022), Trop-2 and CD163 (<i>p</i> = 0.037), and CD47 and CD163 (<i>p</i> < 0.001), respectively. Kaplan–Meier survival analysis revealed that patients with low Trop-2 expression exhibited significantly prolonged OS (<i>p</i> = 0.021) and progression-free survival (PFS) (<i>p</i> = 0.026) compared to those with high Trop-2 expression. Univariate and multivariate analyses revealed significant associations between OS and PFS for Trop-2, lymphovascular invasion, and BRCA status. <b>Conclusions</b>: Trop-2 expression is a significant prognostic factor for TNBC and is correlated with worse outcomes. Although CD47 and CD163 showed trends for poorer prognosis, their significance was not confirmed. These findings offer promising prospects for future studies on combined antibody–drug conjugates (ADCs), as they may present opportunities to address multiple resistance mechanisms in the management of TNBC and enhance clinical outcomes. |
| format | Article |
| id | doaj-art-8c3663b0247b47a5871e3dd8539aeabe |
| institution | Kabale University |
| issn | 2075-4418 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj-art-8c3663b0247b47a5871e3dd8539aeabe2025-01-24T13:29:12ZengMDPI AGDiagnostics2075-44182025-01-0115223210.3390/diagnostics15020232Exploring the Prognostic Role of Trop-2, CD47, and CD163 Expression Levels on Survival Outcomes in Patients with Triple-Negative Breast CancerRamazan Oguz Yüceer0Sedanur Aydın1Iclal Gelir2Tulay Koc3Ersin Tuncer4Mahmut Ucar5Department of Pathology, Sivas Cumhuriyet University School of Medicine, Sivas 58140, TurkeyDepartment of Pathology, Sivas Cumhuriyet University School of Medicine, Sivas 58140, TurkeySivas Cumhuriyet University School of Medicine, Sivas 58140, TurkeyDepartment of Pathology, Sivas Cumhuriyet University School of Medicine, Sivas 58140, TurkeyDepartment of Pathology, Sivas Cumhuriyet University School of Medicine, Sivas 58140, TurkeyDepartment of Medical Oncology, Sivas Cumhuriyet University School of Medicine, Sivas 58140, Turkey<b>Background</b>: This study evaluated the prognostic impact of Trop-2, CD47, and CD163 expression on clinical outcomes in triple-negative breast cancer (TNBC) and investigated their interactions with tumor progression. <b>Methods</b>: A retrospective cohort of 92 patients with TNBC was analyzed. The expression scores for Trop-2, CD47, and CD163 were categorized as negative/low (0–3 points) or high (4–6 points). The primary endpoint was overall survival (OS). <b>Results</b>: The median age of the cohort was 50 years old. High Trop-2 expression was observed in 55.4% of the patients and was significantly associated with advanced disease stage (<i>p</i> < 0.001). High CD47 expression (44.6%) was correlated with advanced stage (<i>p</i> = 0.044), whereas high CD163 expression (45.7%) was associated with advanced stage (<i>p</i> = 0.021), absence of comorbidities (<i>p</i> = 0.022), and lower pT stage (<i>p</i> = 0.023). Moderate positive correlations were found between Trop-2 and CD47 (<i>p</i> = 0.022), Trop-2 and CD163 (<i>p</i> = 0.037), and CD47 and CD163 (<i>p</i> < 0.001), respectively. Kaplan–Meier survival analysis revealed that patients with low Trop-2 expression exhibited significantly prolonged OS (<i>p</i> = 0.021) and progression-free survival (PFS) (<i>p</i> = 0.026) compared to those with high Trop-2 expression. Univariate and multivariate analyses revealed significant associations between OS and PFS for Trop-2, lymphovascular invasion, and BRCA status. <b>Conclusions</b>: Trop-2 expression is a significant prognostic factor for TNBC and is correlated with worse outcomes. Although CD47 and CD163 showed trends for poorer prognosis, their significance was not confirmed. These findings offer promising prospects for future studies on combined antibody–drug conjugates (ADCs), as they may present opportunities to address multiple resistance mechanisms in the management of TNBC and enhance clinical outcomes.https://www.mdpi.com/2075-4418/15/2/232breast cancertriple-negativeTrop-2CD47CD163tumor-associated macrophages |
| spellingShingle | Ramazan Oguz Yüceer Sedanur Aydın Iclal Gelir Tulay Koc Ersin Tuncer Mahmut Ucar Exploring the Prognostic Role of Trop-2, CD47, and CD163 Expression Levels on Survival Outcomes in Patients with Triple-Negative Breast Cancer Diagnostics breast cancer triple-negative Trop-2 CD47 CD163 tumor-associated macrophages |
| title | Exploring the Prognostic Role of Trop-2, CD47, and CD163 Expression Levels on Survival Outcomes in Patients with Triple-Negative Breast Cancer |
| title_full | Exploring the Prognostic Role of Trop-2, CD47, and CD163 Expression Levels on Survival Outcomes in Patients with Triple-Negative Breast Cancer |
| title_fullStr | Exploring the Prognostic Role of Trop-2, CD47, and CD163 Expression Levels on Survival Outcomes in Patients with Triple-Negative Breast Cancer |
| title_full_unstemmed | Exploring the Prognostic Role of Trop-2, CD47, and CD163 Expression Levels on Survival Outcomes in Patients with Triple-Negative Breast Cancer |
| title_short | Exploring the Prognostic Role of Trop-2, CD47, and CD163 Expression Levels on Survival Outcomes in Patients with Triple-Negative Breast Cancer |
| title_sort | exploring the prognostic role of trop 2 cd47 and cd163 expression levels on survival outcomes in patients with triple negative breast cancer |
| topic | breast cancer triple-negative Trop-2 CD47 CD163 tumor-associated macrophages |
| url | https://www.mdpi.com/2075-4418/15/2/232 |
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