Molecular Mechanisms and Functions of lncRNAs in the Inflammatory Reaction of Diabetes Mellitus
Diabetes is a chronic inflammatory state, and several studies have shown that the mechanisms of insulin resistance and abnormal islet β-cell function in diabetes are closely related to inflammatory reactions. Inflammation plays a critical role in diabetic complications. Long noncoding RNAs (lncRNAs)...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2021/2550399 |
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| author | Linjuan Huang Xiaolei Hu |
| author_facet | Linjuan Huang Xiaolei Hu |
| author_sort | Linjuan Huang |
| collection | DOAJ |
| description | Diabetes is a chronic inflammatory state, and several studies have shown that the mechanisms of insulin resistance and abnormal islet β-cell function in diabetes are closely related to inflammatory reactions. Inflammation plays a critical role in diabetic complications. Long noncoding RNAs (lncRNAs), a new area of genomic research for gene regulation, have complex biological functions in various aspects of cellular biological activity. Recent studies have shown that lncRNAs are associated with the regulation of inflammatory responses in various ways, including at the epigenetic, transcriptional, and posttranscriptional levels. This paper presents a brief review of studies on the mechanisms of lncRNAs in diabetic inflammation. The purpose of this article is to determine the role of lncRNAs in the process of diabetic inflammation and to provide new strategies for the use of lncRNAs in the treatments for diabetic inflammation. |
| format | Article |
| id | doaj-art-8c3519b3562149c0bfa37f0edbad4916 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-8c3519b3562149c0bfa37f0edbad49162025-02-03T01:27:19ZengWileyInternational Journal of Endocrinology1687-83371687-83452021-01-01202110.1155/2021/25503992550399Molecular Mechanisms and Functions of lncRNAs in the Inflammatory Reaction of Diabetes MellitusLinjuan Huang0Xiaolei Hu1Department of Endocrinology, The First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, ChinaDiabetes is a chronic inflammatory state, and several studies have shown that the mechanisms of insulin resistance and abnormal islet β-cell function in diabetes are closely related to inflammatory reactions. Inflammation plays a critical role in diabetic complications. Long noncoding RNAs (lncRNAs), a new area of genomic research for gene regulation, have complex biological functions in various aspects of cellular biological activity. Recent studies have shown that lncRNAs are associated with the regulation of inflammatory responses in various ways, including at the epigenetic, transcriptional, and posttranscriptional levels. This paper presents a brief review of studies on the mechanisms of lncRNAs in diabetic inflammation. The purpose of this article is to determine the role of lncRNAs in the process of diabetic inflammation and to provide new strategies for the use of lncRNAs in the treatments for diabetic inflammation.http://dx.doi.org/10.1155/2021/2550399 |
| spellingShingle | Linjuan Huang Xiaolei Hu Molecular Mechanisms and Functions of lncRNAs in the Inflammatory Reaction of Diabetes Mellitus International Journal of Endocrinology |
| title | Molecular Mechanisms and Functions of lncRNAs in the Inflammatory Reaction of Diabetes Mellitus |
| title_full | Molecular Mechanisms and Functions of lncRNAs in the Inflammatory Reaction of Diabetes Mellitus |
| title_fullStr | Molecular Mechanisms and Functions of lncRNAs in the Inflammatory Reaction of Diabetes Mellitus |
| title_full_unstemmed | Molecular Mechanisms and Functions of lncRNAs in the Inflammatory Reaction of Diabetes Mellitus |
| title_short | Molecular Mechanisms and Functions of lncRNAs in the Inflammatory Reaction of Diabetes Mellitus |
| title_sort | molecular mechanisms and functions of lncrnas in the inflammatory reaction of diabetes mellitus |
| url | http://dx.doi.org/10.1155/2021/2550399 |
| work_keys_str_mv | AT linjuanhuang molecularmechanismsandfunctionsoflncrnasintheinflammatoryreactionofdiabetesmellitus AT xiaoleihu molecularmechanismsandfunctionsoflncrnasintheinflammatoryreactionofdiabetesmellitus |